provirion

English Journal

Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus.

Matsui T, Lander GC, Khayat R, Johnson JE.SourceDepartment of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2010 Aug 10;107(32):14111-5. doi: 10.1073/pnas.1004221107. Epub 2010 Jul 26.
Effective antiviral agents are difficult to develop because of the close relationship between the cell biology of the virus and host. However, viral capsid maturation, the in vivo process where the particle transitions from a noninfectious provirion to an infectious virion, is an ideal process to in
PMID 20660783

Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation.

Jin YJ, Cai CY, Zhang X, Burakoff SJ.SourceDepartment of Medicine, New York University School of Medicine, New York, NY 10016, USA. Yong-Jiu.Jin@mssm.edu
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2008 Jun 15;180(12):7878-86.
Nef is a HIV-1 accessory protein critical for the replication of the virus and the development of AIDS. The major pathological activity of Nef is the down-regulation of CD4, the primary receptor of HIV-1 infection. The mechanism underlying Nef-mediated CD4 endocytosis and degradation remains incompl
PMID 18523251

Maturation of a tetravirus capsid alters the dynamic properties and creates a metastable complex.

Bothner B, Taylor D, Jun B, Lee KK, Siuzdak G, Schultz CP, Johnson JE.SourceScripps Research Institute, Department of Molecular Biology, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. bbothner@chemistry.montana.edu
Virology.Virology.2005 Mar 30;334(1):17-27.
The assembly of monomeric protein subunits into a viral capsid is a finely tuned molecular process. In response to subtle changes in environmental conditions, this supramolecular complex can dramatically reorganize. Defining the forces that control this structure and the cooperative action of subuni
PMID 15749119