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1. 子宮内避妊器具：挿入および除去intrauterine contraception insertion and removal [show details]
… Clinics that offer IUD insertions should have a protocol that includes counseling, screening (including exclusion of pregnancy), and insertion of the IUD in one visit . Single-visit insertion results in more …
2. 証拠、p値、および仮説検定proof p values and hypothesis testing [show details]
…used in research, it is generally to decide whether or not to reject the "null hypothesis." The null hypothesis is the hypothesis that will be statistically assumed until some level of statistical evidence …
3. 臍帯卵膜付着と前置血管velamentous umbilical cord insertion and vasa previa [show details]
…multifetal pregnancies . The pathogenesis of velamentous cord insertion is unknown. The most popular hypothesis is that the cord initial insertion site is central, but this location progressively becomes peripheral …
4. 肺動脈カテーテル法：成人における挿入手技pulmonary artery catheters insertion technique in adults [show details]
…for insertion. Additional clinicians may be necessary in the intensive care unit to care for unattended patients as PAC insertion can be time-consuming. As an example in a study of 120 insertions, the …
5. B型肝炎ウイルス遺伝子型の臨床的意義clinical significance of hepatitis b virus genotypes [show details]
… the basal core promoter mutations are not yet fully understood. Some but not all in vitro studies suggested that these changes may increase HBV replication. The core promoter variant has been… Two studies from Japan with 57 and 53 cases of acute hepatitis supported the hypothesis that genotype A more often progressed to chronicity than genotype C .…

English Journal

Extracellular DNA Containing (dG)n Motifs Penetrates into MCF7 Breast Cancer Cells, Induces the Adaptive Response, and Can Be Expressed.

Kozhina EA, Ershova ES, Okorokova NA, Veiko VP, Malinovskaya EM, Sergeeva VA, Konkova MS, Kutsev SI, Veiko NN, Kostyuk SV.
Oxidative medicine and cellular longevity. 2019 ;2019()7853492.
Oxidized human DNA or plasmid DNAs containing human ribosomal genes can easily penetrate into the breast cancer cells MCF7 and stimulate the adaptive response induction. Plasmid DNA containing a CMV promoter, gene , and the insertion of the human ribosomal genes can be expressed. A hypothesis is pro
PMID 31781350

Deregulation of methanol metabolism reverts transcriptional limitations of recombinant Pichia pastoris (Komagataella spp) with multiple expression cassettes under control of the AOX1 promoter.

Cámara E, Monforte S, Albiol J, Ferrer P.
Biotechnology and bioengineering. 2019 07;116(7)1710-1720.
The methanol-regulated alcohol oxidase promoter (P ) of Pichia pastoris (syn. Komagataella spp. ) is one of the strongest promoters for heterologous gene expression. Although increasing the gene dosage is a common strategy to improve recombinant protein productivities, P. pastoris strains harboring
PMID 30712270

A PDE3A Promoter Polymorphism Regulates cAMP-Induced Transcriptional Activity in Failing Human Myocardium.

Sucharov CC, Nakano SJ, Slavov D, Schwisow JA, Rodriguez E, Nunley K, Medway A, Stafford N, Nelson P, McKinsey TA, Movsesian M, Minobe W, Carroll IA, Taylor MRG, Bristow MR.
Journal of the American College of Cardiology. 2019 03;73(10)1173-1184.
The phosphodiesterase 3A (PDE3A) gene encodes a PDE that regulates cardiac myocyte cyclic adenosine monophosphate (cAMP) levels and myocardial contractile function. PDE3 inhibitors (PDE3i) are used for short-term treatment of refractory heart failure (HF), but do not produce uniform long-term benefi
PMID 30871701

Japanese Journal

<i>mPing</i>: The bursting transposon

Naito Ken,Monden Yuki,Yasuda Kanako [他],Saito Hiroki,Okumoto Yutaka
Ｂｒｅｅｄｉｎｇ　Ｓｃｉｅｎｃｅ 64(2), 109-114, 2014
… Though transposable elements (TEs) have been considered as an efficient source of evolution, it has never been possible to test this hypothesis because most of TE insertions had occurred millions of years ago, or because currently active TEs have very few copies in a host genome. … insertion sites has revealed it avoids exons but prefers promoter regions and thus moderately affects transcription of neighboring genes. …
NAID 130004146428