プロカインベンジルペニシリン
WordNet
- a white crystalline powder (trade name Ethocaine) administered near nerves as a local anesthetic in dentistry and medicine (同)Ethocaine
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- パロカイン(局所麻酔な用いる薬品)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/05 14:48:22」(JST)
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Procaine benzylpenicillin
| Combination of |
| Benzylpenicillin |
antibiotic |
| Procaine |
anaesthetic |
| Clinical data |
| AHFS/Drugs.com |
Monograph |
| ATC code |
J01CE09 (WHO) QJ51CE09 (WHO) |
| Legal status |
| Legal status |
|
| Identifiers |
| CAS Number |
54-35-3 Y |
| ChEMBL |
CHEMBL1628385 N |
| E number |
E707 (antibiotics) |
| NY (what is this?) (verify) |
Procaine benzylpenicillin (rINN), also known as procaine penicillin, is an antibiotic useful for the treatment of a number of bacterial infections.
It is a form of penicillin which is a combination of benzylpenicillin and the local anaesthetic agent procaine. Following deep intramuscular injection, it is slowly absorbed into the circulation and hydrolysed to benzylpenicillin — thus it is used where prolonged low concentrations of benzylpenicillin are required.
This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[1]
Contents
- 1 Uses
- 2 Adverse effects
- 3 Compendial status
- 4 References
Uses
Specific indications for procaine penicillin include:[2]
- Syphilis
- In the United States, Bicillin C-R (a injectable suspension which 1.2 million units of benzathine penicillin and 1.2 million units of procaine penicillin per 4 ml) is not recommended for treating syphilis, since it contains only half the recommended dose of benzathine penicillin. Medication errors have been made due to the confusion between Bicillin L-A & Bicillin C-R.[3] As a result, changes in product packaging have been made; specifically, the statement "Not for the Treatment of Syphilis" has been added in red text to both the Bicillin CR and Billin CR 900/300 syringe labels.[4]
- Respiratory tract infections where compliance with oral treatment is unlikely
- Alongside Pen V and Erythromycin, Bicillin C-R is used to treat strep throat, given as one IM injection
- Cellulitis, erysipelas
- Procaine penicillin is also used as an adjunct in the treatment of anthrax.
Adverse effects
Further information: Penicillin drug reaction
At high doses procaine penicillin can cause seizures and CNS abnormalities due to procaine present in it.
Compendial status
- British Pharmacopoeia [5]
References
- ^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
- ^ Rossi S, editor, ed. (2006). Australian Medicines Handbook. Adelaide: Australian Medicines Handbook. ISBN 0-9757919-2-3.
- ^ Centers for Disease Control and Prevention (CDC) (2005). "Inadvertent use of Bicillin C-R to treat syphilis infection—Los Angeles, California, 1999–2004". MMWR Morb. Mortal. Wkly. Rep. 54 (9): 217–9. PMID 15758893.
- ^ United States Food & Drug Administration. "FDA Strengthens Labels of Two Specific Types of Antibiotics to Ensure Proper Use." Published December 1, 2004. Last accessed June 18, 2007.
- ^ British Pharmacopoeia Commission Secretariat. "Index (BP 2009)" (PDF). Retrieved 26 March 2010.
|
Antibacterials: cell envelope antibiotics (J01C-J01D)
|
|
| Intracellular |
- Inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
|
|
| Glycopeptide |
- Inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
|
|
β-lactams/
(inhibit PBP
cross-links) |
|
|
| Other |
- polymyxins/detergent
- depolarizing
- Hydrolyze NAM-NAG
- Tyrothricin
- Isoniazid
- Teixobactin
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
UpToDate Contents
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English Journal
- Arumugam D, Atherton JJ, Martin PT.SourceDepartment of Cardiology, Royal Jubilee Hospital, Victoria, British Columbia, Canada. deepak_mugsy@yahoo.com.au
- Lancet.Lancet.2012 Feb 4;379(9814):492.
- PMID 22305227
- Naturally occurring cutaneous anthrax: antibiotic treatment and outcome.
- Kayabas U, Karahocagil MK, Ozkurt Z, Metan G, Parlak E, Bayindir Y, Kalkan A, Akdeniz H, Parlak M, Simpson AJ, Doganay M.SourceDepartment of Infectious Diseases, Inonu University, Malatya, Turkey. uner.kayabas@inonu.edu.tr
- Chemotherapy.Chemotherapy.2012;58(1):34-43. Epub 2012 Feb 10.
- OBJECTIVES: Cutaneous anthrax (CA) is the most common clinical presentation in human anthrax, but the duration of antibiotic therapy in naturally occurring CA is controversial. The aim of this study was to compare the clinical outcomes of patients receiving antibiotic treatment for either 3-5 days (
- PMID 22343361
Japanese Journal
- A Population-based Case-Control Teratological Study of Three Parenteral Penicillins G
- ベンジルペニシリン重合体と血清たんぱくとの結合性 とくに連続向流透析法での解析:とくに連続向流透析法での解析
Related Links
- Take procaine benzylpenicillin exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. The Procaine Benzylpenicillin dose your doctor recommends will be based on the following (use any or all ...
- Benzylpenicillin: powder for injection, 600 mg (=1 million IU), 3g (=5 million IU) (as sodium or potassium salt) in 5-ml vial Benzathine benzylpenicillin: powder for injection, 1.44 g of benzylpenicillin (=2,4 million IU) in 5-ml vial Procaine ...
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- 英
- procaine benzylpenicillin
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プロカイン
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ベンジルペニシリン
- 関
- benzathine benzylpenicillin、benzylpenicillin benzathine hydrate、benzylpenicillin potassium、penicillin G
- 関
- Penicillin G