WordNet
- a minute vein continuous with a capillary (同)venula, capillary vein
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- 1. 若年性特発性関節炎：疫学と免疫病態学 juvenile idiopathic arthritis epidemiology and immunopathogenesis
- 2. 血管免疫芽球性Ｔ細胞性リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of angioimmunoblastic t cell lymphoma
- 3. T細胞前リンパ球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of t cell prolymphocytic leukemia
- 4. 成人T細胞性白血病/リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of adult t cell leukemia lymphoma
- 5. マントル細胞リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of mantle cell lymphoma
English Journal
- Characterization of Platelet-Monocyte Complexes in HIV-1-Infected Individuals: Possible Role in HIV-Associated Neuroinflammation.
- Singh MV1, Davidson DC, Jackson JW, Singh VB, Silva J, Ramirez SH, Maggirwar SB.Author information 1Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642.AbstractHIV-1-associated neuroinflammation persists even with effective combined antiretroviral therapy, and it is associated with the presence of activated monocytes/macrophages within the CNS. To infiltrate the CNS, monocytes transmigrate across the selectively permeable blood-brain barrier, which is compromised during HIV-1 infection. Interestingly, platelet-derived excess soluble CD40 ligand found in the plasma and cerebrospinal fluid of HIV-1-infected individuals with cognitive impairment has previously been implicated in increased blood-brain barrier permeability. In this study we show that soluble CD40 ligand also promotes the formation of complexes between inflammatory monocytes and activated platelets (PMCs), which are detected by flow cytometry as monocytes that express excess of CD61, a platelet marker, and that these complexes are increased in individuals with HIV-1 infection. PMCs exhibit an enhanced ability to adhere to human brain microvascular endothelial cells as compared with monocytes alone, and they migrate across the transendothelial barrier. These complexes can be found marginalized in the lumen of postcapillary venules in postmortem brain tissue derived from cases of HIV-1-associated encephalitis. The extravasation of monocytes across the brain endothelium may exacerbate neuroinflammation, indicating that enhancing this event via platelet interaction may be a contributing factor in the development of cognitive impairment. Thus, dampening platelet activation, and in turn PMC formation, with antiplatelet agents may prove beneficial in developing adjunctive therapies for use in combination with combined antiretroviral therapy in an effort to reduce HIV-1-associated neurologic deficit.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Apr 11. [Epub ahead of print]
- HIV-1-associated neuroinflammation persists even with effective combined antiretroviral therapy, and it is associated with the presence of activated monocytes/macrophages within the CNS. To infiltrate the CNS, monocytes transmigrate across the selectively permeable blood-brain barrier, which is comp
- PMID 24729609
- A composite model of the human postcapillary venule for investigation of microvascular leukocyte recruitment.
- Lauridsen HM1, Pober JS, Gonzalez AL.Author information 11Malone Engineering Center 314, Yale University, 55 Prospect Street, New Haven, CT 06520, USA. anjelica.gonzalez@yale.edu.AbstractNeutrophil extravasation occurs across postcapillary venules, structures composed of endothelial cells (ECs), pericytes (PCs), and basement membrane (BM). We constructed composite models of the human postcapillary venule, combining ECs with PCs or PC-deposited BM, to better study this process. Quiescent and tumor necrosis factor α (TNF-α)-activated composites demonstrated in situ-like expression of cadherins, E-selectin, intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), platelet-endothelial cell adhesion molecule 1 (PECAM-1), CD99, and interleukin 8 (IL-8). After TNF-α activation, the ECs supported greater neutrophil adhesion (66.1 vs. 23.7% of input cells) and transmigration (35.1 vs. 7.20% of input cells) than did the PCs, but the composites behaved comparably (no significant difference) to ECs in both assays. TNF-α-activated EC-conditioned medium (CM) increased transmigration across the PCs, whereas TNF-α-activated PC-CM decreased transmigration across the ECs, and culturing on PC-derived BM decreased both adhesion to and transmigration across the ECs. Anti-very late antigen 4 (VLA-4; on neutrophils) inhibited adhesion to TNF-α-activated composites, but not to ECs alone. Anti-CD99 (expressed on all 3 cell types) inhibited transmigration across the composites (14.5% of control) more than across the ECs (39.0% of control), and venular shear stress reduced transmigration across the ECs (17.3% of static) more than across the composites (36.7% of static). These results provide proof of concept that our composite human EC/PC/BM venular construct can reveal new interactions in the inflammatory cascade.
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2014 Mar;28(3):1166-80. doi: 10.1096/fj.13-240986. Epub 2013 Dec 2.
- Neutrophil extravasation occurs across postcapillary venules, structures composed of endothelial cells (ECs), pericytes (PCs), and basement membrane (BM). We constructed composite models of the human postcapillary venule, combining ECs with PCs or PC-deposited BM, to better study this process. Quies
- PMID 24297702
Japanese Journal
- リンパ球の動態制御と免疫監視
- 田中 稔之,梅本 英司,宮坂 昌之
- 日本臨床免疫学会会誌 = Japanese journal of clinical immunology 29(6), 359-371, 2006-12-31
- 獲得免疫の中枢をになうリンパ球は全身を巡回して病原体の侵入に速やかに対応する．ナイーブリンパ球はリンパ節やパイエル板などの二次リンパ組織を循環して病原微生物の侵入を監視している．リンパ球は二次リンパ組織で抗原感作をうけると，活性化とともにその遊走特性をリプログラムして末梢の標的組織に移住してエフェクター機能を発揮する．感作T細胞の組織トロピズムの誘導には，二次リンパ組織に分布する組織特異的な樹 …
- NAID 10018714012
- Expression of cutaneous lymphocyte-associated antigen (CLA) in tonsillar T-cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris (PPP)
- 原渕 保明,Nozawa H,Kishibe K,Takahara M
- Clinical Immunology 116(1), 42-53, 2005-07-00
- … The CLA/CD3 double-positive cells and the postcapillary venule that expressed with a ligand of CLA, E-selectin, were found more frequently in the plantar skin from patients with PPP as compared to that from healthy volunteers (P < …
- NAID 120003161779
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- post·cap·il·lar·y venule (pōst-kăp′ə-lĕr′ē) n. Histamine-sensitive microvasculature that is the site of extravasation of blood cells. Also called pericytic venule. postcapillary a venous capillary. postcapillary venule located in lymphoid ...
- postcapillary venule post·cap·il·lar·y venule (pōst-kāp'ə-lěr'ē) n. Histamine-sensitive microvasculature that is the site of extravasation of blood cells. Also called pericytic venule.
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