WordNet
- an impairment of health or a condition of abnormal functioning
- caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
- of or relating to an inheritable character that is controlled by several genes at once; of or related to or determined by polygenes
PrepTutorEJDIC
- (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
- 女性の話術芸人 =diseur
- 病気にかかった / 病的な,不健全な(morbid)
UpToDate Contents
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- 1. LDLコレステロール代謝の遺伝性疾患 inherited disorders of ldl cholesterol metabolism
- 2. 先天異常の遺伝学的および環境的原因 genetic and environmental causes of birth defects
- 3. 心房細動の疫学および危険因子 epidemiology of and risk factors for atrial fibrillation
- 4. 複合形質の遺伝の原則 principles of complex trait genetics
- 5. 遺伝性疾患の基本原則 basic principles of genetic disease
English Journal
- A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model.
- Rudd DS1, Axelsen M, Epping EA, Andreasen NC, Wassink TH.
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.Am J Med Genet B Neuropsychiatr Genet.2014 Dec;165(8):619-26. doi: 10.1002/ajmg.b.32266. Epub 2014 Sep 16.
- Schizophrenia is a chronic and severe psychiatric disorder that is highly heritable. While both common and rare genetic variants contribute to disease risk, many questions still remain about disease etiology. We performed a genome-wide analysis of copy number variants (CNVs) in 166 schizophrenia sub
- PMID 25228354
- Hypertensive Renal Injury Is Associated with Gene Variation Affecting Immune Signaling.
- Braun MC1, Herring SM2, Gokul N2, Monita M2, Bell R2, Zhu Y2, Gonzalez-Garay ML2, Wenderfer SE1, Doris PA3.
- Circulation. Cardiovascular genetics.Circ Cardiovasc Genet.2014 Nov 3. pii: CIRCGENETICS.114.000533. [Epub ahead of print]
- BACKGROUND: -The spontaneously hypertensive rat (SHR) strain exists in lines that contrast strongly in susceptibility to renal injury in hypertension. These inbred lines share common ancestry and only 13% of their genomes arise from different ancestors.METHODS AND RESULTS: -We used next gen sequenci
- PMID 25366137
- Segregation analysis suggests that keratoconus is a complex non-mendelian disease.
- Kriszt A1, Losonczy G, Berta A, Vereb G, Takács L.
- Acta ophthalmologica.Acta Ophthalmol.2014 Nov;92(7):e562-8. doi: 10.1111/aos.12389. Epub 2014 Mar 16.
- PURPOSE: Complex segregation analysis of 60 unrelated sporadic keratoconus (KC) families was performed to reveal the presumed mode of inheritance in our dataset.METHODS: Sixty probands, 212 family members and 212 age and gender matched healthy controls underwent clinical and videokeratographic exami
- PMID 24629050
Japanese Journal
- Genomic study of ossification of the posterior longitudinal ligament of the spine
- IKEGAWA Shiro
- Proceedings of the Japan Academy, Series B 90(10), 405-412, 2014
- … Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common disease after the middle age. … however most of OPLL is idiopathic and is considered as a multi-factorial (polygenic) disease influenced by genetic and environmental factors. …
- NAID 130004704859
- Genes and molecules related to obesity and lifestyle-related disease and exercise
- KIMURA Masaki
- The journal of physical fitness and sports medicine : JPFSM 2(1), 111-115, 2013-03-25
- NAID 10031159024
- Genomics of Vasculitis: Lessons from Mouse Models
- Nose Masato,Komori Hiroaki,Miyazaki Tatsuhiko,Mori Shiro
- Annals of Vascular Diseases 6(1), 16-21, 2013
- … In the study of susceptibility loci to vasculitis in MRL mouse models, we found that systemic vasculitis developed through the cumulative effect of multiple gene loci, each of which by itself did not have a significant effect in inducing the related phenotype, thus indicating a polygenic system.The mice developed vasculitis in an additive manner with a hierarchical effect. …
- NAID 130004487995
Related Links
- Polygenic disease: A genetic disorder that is caused by the combined action of more than one gene. Examples of polygenic conditions include hypertension, coronary heart disease, and diabetes. Because such disorders depend on the ...
- Genetic disorders may also be complex, multifactorial, or polygenic, meaning they are likely associated with the effects of multiple genes in combination with lifestyles and ...
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★リンクテーブル★
| リンク元 | 「多遺伝子疾患」「多遺伝子性疾患」 |
| 関連記事 | 「disease」「polygenic」 |
「多遺伝子疾患」
「多遺伝子性疾患」
「disease」
- n.
- 疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
- 特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
- something that is very wrong with people's attitudes, way of life or with society.
- 注意
「polygenic」
- adj.
- 多遺伝子性の、多遺伝子の、多因子の、ポリジーンの