polycistronic

・リシストロニックな、多シストロン性の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/07 05:07:08」(JST)

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A cistron is a gene. The term cistron is used to emphasize that genes exhibit a specific behavior in a cis-trans test; distinct positions (or loci) within a genome are cistronic.

For example, suppose a mutation at a chromosome position is responsible for a recessive trait in a diploid organism (where chromosomes come in pairs). We say that the mutation is recessive because the organism will exhibit the wild type phenotype (ordinary trait) unless both chromosomes of a pair have the mutation (homozygous mutation). Similarly, suppose a mutation at another position, , is responsible for the same recessive trait. The positions and are said to be within the same cistron when an organism that has the mutation at on one chromosome and has the mutation at position on the paired chromosome exhibits the recessive trait even though the organism is not homozygous for either mutation. When instead the wild type trait is expressed, the positions are said to belong to distinct cistrons / genes.

For example, an operon is a stretch of DNA that is transcribed to create a contiguous segment of RNA, but contains more than one cistron / gene. The operon is said to be polycistronic, whereas ordinary genes are said to be monocistronic.

References

English Journal

• Engineering of Corynebacterium glutamicum for xylitol production from lignocellulosic pentose sugars.

• Dhar KS1, Wendisch VF2, Nampoothiri KM3.
• Journal of biotechnology.J Biotechnol.2016 Jul 20;230:63-71. doi: 10.1016/j.jbiotec.2016.05.011. Epub 2016 May 13.
• Xylitol is a non-fermentable sugar alcohol used as sweetener. Corynebacterium glutamicum ATCC13032 was metabolically engineered for xylitol production from the lignocellulosic pentose sugars xylose and arabinose. Direct conversion of xylose to xylitol was achieved through the heterologous expression
• PMID 27184428

• Development of the intein-mediated method for production of recombinant thymosin β4 from the acetylated in vivo fusion protein.

• Esipov RS1, Makarov DA2, Stepanenko VN3, Miroshnikov AI4.
• Journal of biotechnology.J Biotechnol.2016 Jun 20;228:73-81. doi: 10.1016/j.jbiotec.2016.02.021. Epub 2016 Mar 22.
• Thymosin β4 is a 43 amino acid long peptide with an acetylated N-terminal serin that has a high potential as a remedy for healing ulcers, wounds and burns. Although protein biosynthesis offers attractive opportunities in terms of a large-scale production, currently thymosin β4 is mainly produced b
• PMID 27015974

• PacBio Full-length transcriptome profiling of insect mitochondrial gene expression.

• Gao S1, Ren Y1, Sun Y1, Wu Z2, Ruan J2, He B1, Zhang T1, Yu X1, Tian X3, Bu W1.
• RNA biology.RNA Biol.2016 Jun 16:0. [Epub ahead of print]
• In this study, we sequenced the first full-length insect transcriptome using the Erthesina fullo Thunberg based on the PacBio platform. We constructed the first quantitative transcription map of animal mitochondrial genomes and built a straightforward and concise methodology to investigate mitochond
• PMID 27310614

Japanese Journal

• 病原ビブリオにおける鉄獲得系遺伝子の発現制御機構

• 薬学雑誌 136(11), 1525-1532, 2016
• NAID 130005267662

• Multiplexed Fluorescence Imaging of ERK and Akt Activities and Cell-cycle Progression

• Cell Structure and Function 41(2), 81-92, 2016
• NAID 130005165901

• Multiplexed fluorescence imaging of ERK and Akt activities and cell-cycle progression

• Cell Structure and Function advpub(0), 2016
• NAID 130005153329

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専門的でマニアックな話になるだろう。先週ぐらいの話になってしまうけれど、いつものように論文を読んでいたところ、ある論文で2A ペプチドによるPolycistronicな遺伝子発現という今まで知らない技術が使われていた。

• Polycistronic mRNA Definition - Protein Synthesis

Polycistronic mRNA refers to a messenger RNA which encodes two or more proteins. In prokaryotes, polycistronic mRNA participates in the translation. ... Polycistronic vs Monocistronic Polycistronic mRNA refers to a messenger ...

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★リンクテーブル★

リンク元	「多シストロン性」「ポリシストロニック」

「多シストロン性」

　　[★]

英

polycistronic

関

・リシストロニック

「ポリシストロニック」

　　[★]

英

polycistronic

関

多シストロン性