English Journal

Protamine-oligonucleotide-nanoparticles: Recent advances in drug delivery and drug targeting.

Scheicher B1, Schachner-Nedherer AL1, Zimmer A2.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2015 Jul 30;75:54-59. doi: 10.1016/j.ejps.2015.04.009. Epub 2015 Apr 17.
Application of oligonucleotides as active compounds has become a crucial field of pharmaceutical research in recent years. In order to improve inadequate transfection rate and to avoid rapid enzymatic degradation of antisense oligonucleotides (AS-ODNs) a novel nanoparticulate delivery system was rep
PMID 25896372

Designing of dynamic polyethyleneimine (PEI) brushes on polyurethane (PU) ureteral stents to prevent infections.

Gultekinoglu M1, Tunc Sarisozen Y2, Erdogdu C3, Sagiroglu M3, Aksoy EA2, Oh YJ4, Hinterdorfer P4, Ulubayram K5.
Acta biomaterialia.Acta Biomater.2015 Jul 15;21:44-54. doi: 10.1016/j.actbio.2015.03.037. Epub 2015 Apr 4.
Permanent antibacterial coatings have been developed by brush-like polyethyleneimine (PEI) on polyurethane (PU) ureteral stents since bacterial adhesion and biofilm formation with the following encrustation on stent surface limit their long term usage. In order to control or prevent bacterial infect
PMID 25848724

Emulsification synergism in mixtures of polyelectrolyte brush-grafted nanoparticles and surfactants.

Saigal T1, Xu J2, Matyjaszewski K3, Tilton RD4.
Journal of colloid and interface science.J Colloid Interface Sci.2015 Jul 1;449:152-9. doi: 10.1016/j.jcis.2014.12.047. Epub 2014 Dec 24.
HYPOTHESIS: Silica nanoparticles displaying densely grafted poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) polycationic brushes are highly efficient emulsifiers, stabilizing oil-in-water emulsions at concentrations as low as 0.05 to 0.1 wt%. Adding conventional surfactants is expected to alter
PMID 25591823

Japanese Journal

Promotion and Suppression Effects of Cationic Polymer ε-Poly-L-lysine on the Glucose Oxidase Reaction with Ferrocene Derivatives as Oxidants with Different Charges

UEMATSU Kohei,MINAMI Yuto,TAIRA Shu,KATANO Hajime
Analytical Sciences 30(2), 299-308, 2014
… Within this range, the polycationic εPL would be adsorbed onto the GOD surface to enhance the electrostatic interactions of the enzyme with negatively charged substrates, and repulsion with positively charged ones. …
NAID 130004442268

Analytical Methods for the Detection and Purification of ε-Poly-L-lysine for Studying Biopolymer Synthetases, and Bioelectroanalysis Methods for Its Functional Evaluation

KATANO Hajime,UEMATSU Kohei,MARUYAMA Chitose,HAMANO Yoshimitsu
Analytical Sciences 30(1), 17-24, 2014
… The produced amount of εPL in culture broth can be determined based on the precipitation of polycationic εPL with a colored heteropolymolybdate anion and the color change of the supernatant. …
NAID 130004442239

Nagai Junya,Komeda Takuji,Katagiri Yuki [他],Yumoto Ryoko,Takano Mikihisa
Biological and Pharmaceutical Bulletin 36(12), 1942-1949, 2013
… In addition, FITC-protamine association was inhibited by cationic drugs such as polycationic gentamicin and polymixin B, but it was increased by a basic amino acid, arginine. …
NAID 130003382061