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1. チロシン代謝障害 disorders of tyrosine metabolism
2. 慢性骨髄性白血病の治療の概要 overview of the treatment of chronic myeloid leukemia
3. T細胞受容体シグナル伝達 t cell receptor signaling
4. 進行消化管間質腫瘍に対するチロシンキナーゼ阻害剤療法 tyrosine kinase inhibitor therapy for advanced gastrointestinal stromal tumors
5. インスリン受容体の構造および機能 structure and function of the insulin receptor

Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain.

Mohr A, Fahrenkamp D, Rinis N, Müller-Newen G.AbstractBACKGROUND: STAT3 is a transcription factor of central importance in chronic inflammation and cancer. In response to cytokine stimulation STAT3 is phosphorylated on a single tyrosine residue at position 705, dimerizes and accumulates in the nucleus to induce target gene expression. The substitution of tyrosine 705 to phenylalanine leads to a dominant-negative STAT3 mutant (STAT3-YF) which influences the activation of WT-STAT3 in stimulated cells through a mechanism that is not completely understood. In this study we analyzed the molecular mechanism of STAT3-YF dominant-negative activity in IL-6-induced STAT3 signaling and the relevance of the N-terminal domain.
Cell communication and signaling : CCS.Cell Commun Signal.2013 Nov 5;11(1):83. [Epub ahead of print]
BACKGROUND: STAT3 is a transcription factor of central importance in chronic inflammation and cancer. In response to cytokine stimulation STAT3 is phosphorylated on a single tyrosine residue at position 705, dimerizes and accumulates in the nucleus to induce target gene expression. The substitution
PMID 24192293

Interaction of bacterial fatty-acid-displaced regulators with DNA is interrupted by tyrosine phosphorylation in the helix-turn-helix domain.

Derouiche A, Bidnenko V, Grenha R, Pigonneau N, Ventroux M, Franz-Wachtel M, Nessler S, Noirot-Gros MF, Mijakovic I.SourceINRA, UMR1319 Micalis, 78350 Jouy-en-Josas, France, Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Université Paris-Sud 11, 91405 Orsay, France, Proteome Center Tübingen, University of Tübingen, 72076 Tübingen, Germany and Department of Chemical and Biological Engineering, Chalmers University of Technology, 41296 Gothenburg, Sweden.
Nucleic acids research.Nucleic Acids Res.2013 Nov 1;41(20):9371-81. doi: 10.1093/nar/gkt709. Epub 2013 Aug 11.
Bacteria possess transcription regulators (of the TetR family) specifically dedicated to repressing genes for cytochrome P450, involved in oxidation of polyunsaturated fatty acids. Interaction of these repressors with operator sequences is disrupted in the presence of fatty acids, and they are there
PMID 23939619

Pioglitazone does not improve insulin signaling in mice with GH over-expression.

Gesing A, Bartke A, Masternak MM.SourceDepartment of Internal Medicine, Geriatrics Research, Southern Illinois University School of Medicine, 801 North Rutledge Street, Room 4389, Springfield, Illinois 62794-9628, USA Department of Oncological Endocrinology, Medical University of Lodz, Zeligowski Street, No 7/9, 90-752 Lodz, Poland Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska Street, No 32, 60-479 Poznan, Poland.
The Journal of endocrinology.J Endocrinol.2013 Oct 4;219(2):109-17. doi: 10.1530/JOE-13-0124. Print 2013.
Type 2 diabetes and obesity are very serious health problems in both developed and developing countries. An increased level of GH is known to promote insulin resistance. Transgenic (Tg) mice over-expressing bovine GH are short-living and characterized, among other traits, by hyperinsulinemia and inc
PMID 23946430

Calyculin A-Sensitive Protein Phosphatases are Involved in Maintenance of Progressive Movement in Mouse Spermatozoa In Vitro by Suppression of Autophosphorylation of Protein Kinase A

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The Journal of reproduction and development 55(3), 327-334, 2009-06-01
… After incubation, they were used for immunodetection of phosphorylated proteins, PKA and PP1 γ2, assessment for motility and co-immunoprecipitation of PP1γ2 with PKA. … Incubation with calyculin A enhanced the phosphorylation states of several proteins (>250 kDa, 170 kDa, 155 kDa, 140 kDa and 42 kDa for serine/threonine phosphorylation and 70 kDa for tyrosine phosphorylation) and PKA catalytic subunits [at the autophosphorylation residue (Thr-197) for its full enzymatic activation] in the flagella. …
NAID 10024942622

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Transactions of the Materials Research Society of Japan 34(3), 517-520, 2009
… Herein, we studied the propensity of resultant fibrils from PHF6 derivative peptides with charged aromatic amino acid residue at Tyr310. … The physical origin of remarkable stabilization of fibrils by tyrosine phosphorylation is plausibly attributed to the charge pairing with the adjacent lysine residue in a similar fashion to the phosphorylation effect on the growth of amyloid fibril. …
NAID 130005004035

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Genome Informatics 16(1), 44-48, 2005
… Promoter binding of tyrosine-phosphorylated (activated) Stat 1 dimers is essentiell for gene induction, a process that often entails the oligomerization of Stat 1 dimers via interactions of their aminoterminal domains. … The mutation of a single residue (F 77) in the N-domain of Stat 1 was recently demonstrated to preclude both the dephosphorylation and the oligomerization of Stat 1 dimers. …
NAID 130003997399