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1. ヨード欠乏症iodine deficiency disorders [show details]
… Both insufficient and excessive iodine intake can result in thyroid disease. The term "iodine deficiency disorders" refers to all of the consequences of iodine deficiency, which depend on its severity …
2. 食物中の微量ミネラルの概要overview of dietary trace minerals [show details]
… epidemiology of iodine deficiency is described in greater detail in a separate topic review. Iodine is heterogeneously distributed in the environment, with soil and water varying greatly in their iodine content… Ceruloplasmin binds to its receptors on the cell surface; copper is then released from its binding protein and enters the cell.…
3. ヨード誘発性甲状腺機能異常症iodine induced thyroid dysfunction [show details]
… The central role of iodide in thyroid physiology has been known for many years. The four iodine atoms of thyroxine (T4) constitute 65 percent of its weight; the three iodine atoms of triiodothyronine …
4. Overview of thyroid disease and pregnancyoverview of thyroid disease and pregnancy [show details]
… inaccuracy due to changes in binding proteins. In such settings where free T4 measurements appear discordant with TSH measurements, total T4 should also be measured. Iodine requirements are higher in pregnant …
5. ヨウ素による甲状腺機能亢進症の治療iodine in the treatment of hyperthyroidism [show details]
… disease in regions with iodine deficiency (or hyperthyroid patients with toxic adenoma or toxic nodular goiter), iodine administration may exacerbate hyperthyroidism because the iodine provides more substrate …

English Journal

Synergistic antibacterial effects of curcumin modified silver nanoparticles through ROS-mediated pathways.

Song Z, Wu Y, Wang H, Han H.
Materials science & engineering. C, Materials for biological applications. 2019 Jun;99()255-263.
Due to their remarkable antibacterial properties, silver nanoparticles (Ag NPs) and curcumin (CCM) have been widely used in the antimicrobial field. In our study, we have fabricated the uniform and stable silver/curcumin composite nanoparticles by a facile ultrasound treatment process and the synerg
PMID 30889699

Phthalides serve as potent modulators to boost fetal hemoglobin induction therapy for β-hemoglobinopathies.

Chen WR, Chou CC, Wang CC.
Blood advances. 2019 May;3(9)1493-1498.
Fetal hemoglobin (HbF) induction therapy has become the most promising strategy for treating β-hemoglobinopathies, including sickle-cell diseases and β-thalassemia. However, subtle but critical structural difference exists between HbF and normal adult hemoglobin (HbA), which inevitably leads to re
PMID 31072835

Thermal proteome profiling allows quantitative assessment of interactions between tetrachloroethene reductive dehalogenase and trichloroethene.

Türkowsky D, Lohmann P, Mühlenbrink M, Schubert T, Adrian L, Goris T, Jehmlich N, von Bergen M.
Journal of proteomics. 2019 Feb;192()10-17.
Thermal proteome profiling (TPP) is increasingly applied in eukaryotes to investigate protein-ligand binding through protein melting curve shifts induced by the presence of a ligand. In anaerobic bacteria, identification of protein-substrate interactions is a major challenge. We applied TPP to Sulfu
PMID 29879467

Japanese Journal

哺乳類ヘモグロビンの協同作用とボーア効果は協調して酸素の獲得と輸送を行っている : 規範タンパク質における新たな視点

張岩,今井清博,小林道頼
生物物理 47(3), 167-173, 2007-05-25
… The slope of the oxygen equilibrium curve (OEC) of mammalian-hemoglobin (Hb) is maximized at S … (oxygen saturation) value of 0.38, and the slope of the S … is partial oxygen pressure; …
NAID 110006273084

PsbYタンパク質はラン色細菌光化学系IIの表在性タンパク質の結合に関与している

伴亜希子,佐藤和彦,菓子野康浩
日本植物生理学会年会およびシンポジウム　講演要旨集 2006(0), 552-552, 2006
PsbYタンパク質は、光化学系II（系II）複合体に結合していることが示されている膜タンパク質であるが、生理学的機能は依然不明である。また、これまでに報告されたいずれの結晶構造モデルにおいても、その結合位置は示されていない。本研究では、このPsbYタンパク質の機能分析を目的とし、ラン色細菌Synechocystis 6803野生株とPsbY欠失変異株との比較を …
NAID 130006986986

Significance of Affinity and Cooperativity in Oxygen Binding to Hemoglobin of Horse Fetal and Maternal Blood

Zhang Yan,Kobayashi Keiko,Sasagawa Keisuke [他],IMAI Kiyohiro,KOBAYASHI Michiyori
Zoological science 20(9), 1087-1093, 2003-09-25
… The physiological significance of the position and shape of the oxygen equilibrium curve (OEC) of horse hemoglobin (Hb) is considered from the viewpoint of oxygen (O2) transport efficiency and the effectiveness of the Bohr effect. …
NAID 110006162791