WordNet

excitement and elation beyond the bounds of sobriety; "the intoxication of wealth and power"

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Alcohol intoxications during adolescence increase motivation for alcohol in adult rats and induce neuroadaptations in the nucleus accumbens.

Alaux-Cantin S, Warnault V, Legastelois R, Botia B, Pierrefiche O, Vilpoux C, Naassila M.SourceINSERM ERI 24, Groupe de Recherche sur l'Alcool et les Pharmacodépendances (GRAP), Université de Picardie Jules Verne, UFR de Pharmacie, SFR CAP Santé, 1 rue des Louvels, Amiens 80000, France.
Neuropharmacology.Neuropharmacology.2013 Apr;67:521-31. doi: 10.1016/j.neuropharm.2012.12.007. Epub 2012 Dec 31.
Adolescent alcohol binge drinking constitutes a major vulnerability factor to develop alcoholism. However, mechanisms underlying this susceptibility remain unknown. We evaluated the effect of adolescent binge-like ethanol intoxication on vulnerability to alcohol abuse in Sprague-Dawley rats. To mode
PMID 23287538

Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.

Blednov YA, Benavidez JM, Black M, Chandra D, Homanics GE, Rudolph U, Harris RA.SourceWaggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 1 University Station, A4800, Austin, TX 78712, USA. Electronic address: yablednov@austin.utexas.edu.
Neuropharmacology.Neuropharmacology.2013 Apr;67:46-56. doi: 10.1016/j.neuropharm.2012.10.016. Epub 2012 Nov 9.
GABA type A receptors (GABA(A)-R) are important for ethanol actions and it is of interest to link individual subunits with specific ethanol behaviors. We studied null mutant mice for six different GABA(A)-R subunits (α1, α2, α3, α4, α5 and δ). Only mice lacking the α2 subunit showed reduction
PMID 23147414

Mutations in Bacchus reveal a tyramine-dependent nuclear regulator for acute ethanol sensitivity in Drosophila.

Chen J, Wang Y, Zhang Y, Shen P.SourceDepartment of Cellular Biology and Biomedical and Health Sciences Institute, University of Georgia, 500 D. W. Brooks Drive, Athens, GA 30602, USA.
Neuropharmacology.Neuropharmacology.2013 Apr;67:25-31. doi: 10.1016/j.neuropharm.2012.10.013. Epub 2012 Nov 6.
Fruit flies and humans display remarkably similar behavioral responses to ethanol intoxication. Here we report that loss-of-function mutations in the CG9894 gene (now named Bacchus or Bacc) attenuate ethanol sensitivity in flies. Bacc encodes a broadly expressed nuclear protein with a motif similar
PMID 23142736