WordNet
- a trodden path (同)footpath
PrepTutorEJDIC
- 道,小道(path)
UpToDate Contents
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- 1. 大腸癌の分子遺伝学 molecular genetics of colorectal cancer
- 2. 前立腺癌の分子生物学 molecular biology of prostate cancer
- 3. 甲状腺結節および非髄様甲状腺癌におけるオンコジーンおよび腫瘍抑制遺伝子 oncogenes and tumor suppressor genes in thyroid nodules and nonmedullary thyroid cancer
- 4. 進行非小細胞肺癌に対する遺伝子型による個別治療 personalized genotype directed therapy for advanced non small cell lung cancer
- 5. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化 head and neck squamous cell carcinogenesis molecular and genetic alterations
English Journal
- RAF-1 promotes survival of thyroid cancer cells harboring RET/PTC1 rearrangement independently of ERK activation.
- Castro L1, Alves S1, Chaves SR1, Costa JL2, Soares P3, Preto A4.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Nov 5;415:64-75. doi: 10.1016/j.mce.2015.08.006. Epub 2015 Aug 8.
- Thyroid cancer (TC) is frequently associated with BRAF or RAS oncogenic mutations and RET/PTC rearrangements, with aberrant RAF-MEK-ERK and/or PI3K pathway activation. BRAF underlies ERK activation in most TC cells, but not in TPC-1 cells with RET/PTC1 rearrangement. Here, we show that depletion of
- PMID 26265449
- A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3.
- Garama DJ1, Harris TJ1, White CL1, Rossello FJ2, Abdul-Hay M3, Gough DJ4, Levy DE5.
- Molecular and cellular biology.Mol Cell Biol.2015 Nov 1;35(21):3646-56. doi: 10.1128/MCB.00541-15. Epub 2015 Aug 17.
- Increased production of mitochondrion-derived reactive oxygen species (ROS) is characteristic of a metabolic shift observed during malignant transformation. While the exact sources and roles of ROS in tumorigenesis remain to be defined, it has become clear that maintaining redox balance is critical
- PMID 26283727
- Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy.
- Sahin IH1, Iacobuzio-Donahue CA2, O'Reilly EM2,3.
- Expert opinion on therapeutic targets.Expert Opin Ther Targets.2015 Oct 6:1-19. [Epub ahead of print]
- INTRODUCTION: Pancreatic adenocarcinoma remains one of the most clinically challenging cancers despite an in-depth characterization of the molecular underpinnings and biology of this disease. Recent whole-genome-wide studies have elucidated the diverse and complex genetic alterations which generate
- PMID 26439702
Japanese Journal
- Myeloma Overexpressed 2 (Myeov2) Regulates L11 Subnuclear Localization through Nedd8 Modification
- Ebina Manato,Tsuruta Fuminori,Katoh Megumi C.,Kigoshi Yu,Someya Akie,Chiba Tomoki,鶴田 文憲,千葉 智樹
- PLoS ONE 8(6), e65285, 2013-06-00
- … Nucleolus contains a number of proteins including ribosomal proteins that conduct cellular stresses to downstream signaling such as p53 pathway. … Our findings provide a novel link between oncogenic stress and p53 pathway and may shed light on the protective mechanism against cancer. …
- NAID 120005304296
- Ligand-triggered resistance to molecular targeted drugs in lung cancer: Roles of hepatocyte growth factor and epidermal growth factor receptor ligands
- Yano Seiji,Takeuchi Shinji,Nakagawa Takayuki,Yamada Tadaaki
- Cancer Science 103(7), 1189-1194, 2012-07-00
- … For example, hepatocyte growth factor (HGF), the ligand of a tyrosine kinase receptor Met, activates Met and the downstream PI3K/Akt pathway and triggers resistance to EGFR inhibitors in EGFR mutant lung cancer cells. … These observations indicate that signals from oncogenic drivers (EGFR signaling in EGFR -mutant lung cancer and ALK signaling in EML4-ALK lung cancer) and ligand-triggered bypass signals (HGF-Met and EGFR ligands-EGFR, respectively) must be simultaneously blocked to avoid the resistance. …
- NAID 120004140852
- 高線量率と低線量率の放射線誘発白血病の研究から予測される放射線が白血病幹細胞の発生に及ぼす効果
- 廣内 篤久
- 放射線生物研究 47(1), 64-76, 2012-03-00
- NAID 40019325091
Related Links
- (NRAS activates CRAF, and can also turn on another oncogenic pathway known as PI3K.) In tumor samples of five other relapsed patients, a different parallel signaling pathway kicked in, possibly triggering the same cell What’s ...
- Design Fresh frozen tumour samples from 381 colorectal cancer (CRC) patients were collected and mutations in KRAS, BRAF and PIK3CA were assessed. Using microarray data, three individual oncogenic and a combined model ...
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★リンクテーブル★
| リンク元 | 「発癌過程」「発がん過程」 |
| 関連記事 | 「oncogenic」「pathway」 |
「発癌過程」
「発がん過程」
「oncogenic」
- 発癌性の、発癌の、癌化の
- 関
- carcinogenesis、carcinogenetic、carcinogenic、carcinogenicity、malignant transformation、oncogenesis、oncogenic transformation、transform
「pathway」
- 関
- route