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English Journal

Nanoparticles coated with the tumor-penetrating peptide iRGD reduce experimental breast cancer metastasis in the brain.

Hamilton AM1, Aidoudi-Ahmed S, Sharma S, Kotamraju VR, Foster PJ, Sugahara KN, Ruoslahti E, Rutt BK.
Journal of molecular medicine (Berlin, Germany).J Mol Med (Berl).2015 Apr 14. [Epub ahead of print]
Metastasis is the main killer in cancer; consequently, there is great interest in novel approaches to prevent and treat metastatic disease. Brain metastases are particularly deadly, as the protection of the blood-brain barrier obstructs the passage of common anticancer drugs. This study used magneti
PMID 25869026

Label-retaining stromal cells in mouse endometrium awaken for expansion and repair after parturition.

Cao M1, Chan RW, Yeung WS.
Stem cells and development.Stem Cells Dev.2015 Mar 15;24(6):768-80. doi: 10.1089/scd.2014.0225. Epub 2014 Dec 22.
Human and mouse endometrium undergo dramatic cellular reorganization during pregnancy and postpartum. Somatic stem cells maintain homeostasis of the tissue by providing a cell reservoir for regeneration. We hypothesized that endometrial cells with quiescent properties (stem/progenitor cells) were in
PMID 25386902

In vivo radioadaptive response: a review of studies relevant to radiation-induced cancer risk.

Nenoi M1, Wang B2, Vares G2.
Human & experimental toxicology.Hum Exp Toxicol.2015 Mar;34(3):272-83. doi: 10.1177/0960327114537537. Epub 2014 Jun 12.
Radioadaptive response (RAR) describes phenomena where small conditioning doses of ionizing radiation (IR) reduce detrimental effects of subsequent higher IR doses. Current radiation protection regulations do not include RAR because of the large variability in expression among individuals and uncert
PMID 24925363

Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells