モクサベリン
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/17 08:58:41」(JST)
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Moxaverine
|
Systematic (IUPAC) name |
1-benzyl-3-ethyl-6,7-dimethoxyisoquinoline
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Identifiers |
CAS Number |
10539-19-2 Y |
ATC code |
A03AD30 |
PubChem |
CID: 70882 |
ChemSpider |
64045 |
UNII |
P3P08Y1XJ4 Y |
KEGG |
D07089 Y |
Chemical data |
Formula |
C20H21NO2 |
Molecular mass |
307.386 g/mol |
SMILES
-
CCC1=NC(=C2C=C(C(=CC2=C1)OC)OC)CC3=CC=CC=C3
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InChI
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InChI=1S/C20H21NO2/c1-4-16-11-15-12-19(22-2)20(23-3)13-17(15)18(21-16)10-14-8-6-5-7-9-14/h5-9,11-13H,4,10H2,1-3H3
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Key:MYCMTMIGRXJNSO-UHFFFAOYSA-N
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(verify) |
Moxaverine is a drug used to treat functional gastrointestinal disorders.
It is a phosphodiesterase inhibitor.[1]
References
- ^ Mannhold R (December 1988). "Inhibition of calmodulin dependent c-AMP-phosphodiesterase by moxaverine and papaverine". Arzneimittelforschung 38 (12): 1806–8. PMID 2854468.
Drugs for functional gastrointestinal disorders (A03)
|
|
Drugs for
functional
bowel disorders |
Antimuscarinics
|
Tertiary
amino group
|
- Oxyphencyclimine
- Camylofin
- Mebeverine
- Trimebutine
- Rociverine
- Dicycloverine
- Dihexyverine
- Difemerine
- Piperidolate
|
|
Quaternary
ammonium
compounds
|
- Benzilone
- Mepenzolate
- Pipenzolate
- Glycopyrronium
- Oxyphenonium
- Penthienate
- Methantheline
- Propantheline
- Otilonium
- Tridihexethyl
- Isopropamide
- Hexocyclium
- Poldine
- Bevonium
- Diphemanil
- Tiemonium
- Prifinium
- Timepidium
- Fenpiverinium
|
|
|
Phosphodiesterase
inhibitors
|
- Papaverine
- Drotaverine
- Moxaverine
|
|
Acting on
serotonin receptors
|
- 5-HT3 antagonists
- 5-HT4 agonists
- Mosapride
- Prucalopride
- Tegaserod
|
|
Other
|
- Alverine
- Caroverine
- Chlorbenzoxamine
- Diisopromine
- Dimethylaminopropionylphenothiazine
- Fenpiprane
- Fenoverine
- Idanpramine
- Isometheptene
- Phloroglucinol
- Pinaverium
- Proxazole
- Silicones
- Tiropramide
- Trepibutone
- Trimethyldiphenylpropylamine
|
|
|
Belladonna
and derivatives
(antimuscarinics) |
- tertiary amines: Atropine
- Hyoscyamine
- quaternary ammonium compounds:
- Scopolamine
- Butylscopolamine
- Methylscopolamine
- Methylatropine
- Fentonium
- Cimetropium bromide
|
|
Propulsives |
- primarily dopamine antagonists
- Metoclopramide/Bromopride
- Clebopride
- Domperidone
- Alizapride
- 5-HT4 agonists
|
|
Index of digestion
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|
Description |
- Anatomy
- Physiology
- Development
|
|
Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
|
|
Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
|
|
|
English Journal
- Rh(iii)-catalyzed C-H activation/cyclization of oximes with alkenes for regioselective synthesis of isoquinolines.
- Chen R1, Qi J, Mao Z, Cui S.
- Organic & biomolecular chemistry.Org Biomol Chem.2016 Jul 14;14(26):6201-4. doi: 10.1039/c6ob00942e. Epub 2016 Jun 8.
- A Rh(iii)-catalyzed C-H activation/cyclization of oximes and alkenes for facile and regioselective access to isoquinolines has been developed. This protocol features mild reaction conditions and easily accessible starting materials, and has been applied to the concise synthesis of moxaverine. A kine
- PMID 27273816
- Update on current and future novel therapies for dry age-related macular degeneration.
- Leung E1, Landa G.
- Expert review of clinical pharmacology.Expert Rev Clin Pharmacol.2013 Sep;6(5):565-79. doi: 10.1586/17512433.2013.829645. Epub 2013 Aug 24.
- Age-related macular degeneration (ARMD) is the leading cause of irreversible blindness in developed countries. There are currently no cures, but there are promising potential therapies that target the underlying disease mechanisms of dry ARMD. Stem cells, ciliary neurotrophic factor, rheopheresis, o
- PMID 23971874
- Effects of orally administered moxaverine on ocular blood flow in healthy subjects.
- Schmidl D1, Pemp B, Lasta M, Boltz A, Kaya S, Palkovits S, Prager F, Schmetterer L, Garhofer G.
- Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.Graefes Arch Clin Exp Ophthalmol.2013 Feb;251(2):515-20. doi: 10.1007/s00417-012-2207-1. Epub 2012 Dec 1.
- BACKGROUND: To investigate the effect of orally administered moxaverine (Kollateral forte®) on ocular blood flow in young healthy subjects.METHODS: Sixteen healthy subjects (eight male/eight female) aged between 20 and 32 years were included in this placebo-controlled, double-masked, two-way crosso
- PMID 23203292
Related Links
- Moxaverine is a medicine available in a number of countries worldwide. A list of US medications equivalent to Moxaverine is available on the Drugs.com website. ... Drugs.com provides accurate and independent information on more ...
- ^Mannhold R (December 1988). "Inhibition of calmodulin dependent c-AMP-phosphodiesterase by moxaverine and papaverine". Arzneimittelforschung 38 (12): 1806–8. PMID 2854468.
★リンクテーブル★
[★]
- 英
- moxaverine
- 同
- オイパベリン eupaverine
- パパベリンの誘導体?
- ホスホジエステラーゼ阻害薬。
- 機能性胃腸薬(鎮痙薬)として用いられるが、日本で販売されていない、はず。
参考
- http://www.genome.jp/dbget-bin/www_bget?dr_ja:D07089
- http://en.wikipedia.org/wiki/Moxaverine