mitogen-activated protein kinase 13

マイトジェン活性化プロテインキナーゼ13

WordNet

1. aerate (sewage) so as to favor the growth of organisms that decompose organic matter (同)aerate
2. make (substances) radioactive
3. make active or more active; "activate an old file"
4. make more adsorptive; "activate a metal"
5. rendered active; e.g. rendered radioactive or luminescent or photosensitive or conductive
6. (of e.g. a molecule) made reactive or more reactive (同)excited
7. (military) set up and placed on active assignment; "a newly activated unit"
8. (of sewage) treated with aeration and bacteria to aid decomposition
9. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
10. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
11. an agent that triggers mitosis

PrepTutorEJDIC

1. …'を'活動的にする / …‘に'放射能を与える / 〈物質〉'を'活性化する
2. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/14 11:39:20」(JST)

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Main article: Mitogen-activated protein kinase

P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy.

p38 MAP Kinase (MAPK), also called RK or CSBP (Cytokinin Specific Binding Protein) , is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signaling cascade controlling cellular responses to cytokines and stress.

Four p38 MAP kinases, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12 / ERK6), and -δ (MAPK13 / SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), Ultraviolet light, and growth factors.

mitogen-activated protein kinase 11 Identifiers Symbol MAPK11 Alt. symbols PRKM11 Entrez 5600 HUGO 6873 OMIM 602898 RefSeq NM_002751 UniProt Q15759 Other data EC number 2.7.11.24 Locus Chr. 22 q13.33	mitogen-activated protein kinase 12 Identifiers Symbol MAPK12 Alt. symbols SAPK3 Entrez 6300 HUGO 6874 OMIM 602399 RefSeq NM_002969 UniProt P53778 Other data EC number 2.7.11.24 Locus Chr. 22 q13.3
mitogen-activated protein kinase 13 Identifiers Symbol MAPK13 Alt. symbols PRKM13 Entrez 5603 HUGO 6875 OMIM 602899 RefSeq NM_002754 UniProt O15264 Other data EC number 2.7.11.24 Locus Chr. 6 p21	mitogen-activated protein kinase 14 Identifiers Symbol MAPK14 Alt. symbols CSPB1, CSBP1, CSBP2 Entrez 1432 HUGO 6876 OMIM 600289 RefSeq NM_001315 UniProt Q16539 Other data EC number 2.7.11.24 Locus Chr. 6 p21.3-21.2

MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF2, Mac and MEF2. p38 also has been shown to phosphorylate post-transcriptional regulating factors like TTP.

P38 inhibitors

P38 inhibitors are being sought for possible therapeutic effect on autoimmune diseases and inflammatory processes, e.g. pamapimod. Some have started clinical trials, e.g. PH-797804 for COPD. Other p38 inhibitors include BIRB 796, VX-702, SB 239063, SCIO 469, and BMS 582949.

References

External links

• p38 Mitogen-Activated Protein Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
• P38mapkPathway
• p38 Signaling Pathway
• MAP Kinase Resource
• p38 MAPK Pathway

UpToDate Contents

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• 5. 黒色腫（メラノーマ）の分子生物学 the molecular biology of melanoma

English Journal

• p27 suppresses cyclooxygenase-2 expression by inhibiting p38β and p38δ-mediated CREB phosphorylation upon arsenite exposure.

• Che X, Liu J, Huang H, Mi X, Xia Q, Li J, Zhang D, Ke Q, Gao J, Huang C.SourceNelson Institute of Environmental Medicine, New York University, School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA.
• Biochimica et biophysica acta.Biochim Biophys Acta.2013 Sep;1833(9):2083-91. doi: 10.1016/j.bbamcr.2013.04.012. Epub 2013 Apr 29.
• p27 is a cyclin-dependent kinase (CDK) inhibitor that suppresses a cell's transition from G0 to S phase, therefore acting as a tumor suppressor. Our most recent studies demonstrate that upon arsenite exposure, p27 suppresses Hsp27 and Hsp70 expressions through the JNK2/c-Jun- and HSF-1-dependent pat
• PMID 23639288

• An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease.

• Cavallini A, Brewerton S, Bell A, Sargent S, Glover S, Hardy C, Moore R, Calley J, Ramachandran D, Poidinger M, Karran E, Davies P, Hutton M, Szekeres P, Bose S.SourceEli Lilly and Company Limited, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom.
• The Journal of biological chemistry.J Biol Chem.2013 Aug 9;288(32):23331-47. doi: 10.1074/jbc.M113.463984. Epub 2013 Jun 24.
• Neurofibrillary tangles, one of the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates with synaptic loss and severity of dementia. Identifying the kinases involved i
• PMID 23798682

• Downregulation of the expression of mitochondrial electron transport complex genes in autism brains.

• Anitha A, Nakamura K, Thanseem I, Matsuzaki H, Miyachi T, Tsujii M, Iwata Y, Suzuki K, Sugiyama T, Mori N.SourceResearch Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan.
• Brain pathology (Zurich, Switzerland).Brain Pathol.2013 May;23(3):294-302. doi: 10.1111/bpa.12002. Epub 2012 Nov 16.
• Mitochondrial dysfunction (MtD) and abnormal brain bioenergetics have been implicated in autism, suggesting possible candidate genes in the electron transport chain (ETC). We compared the expression of 84 ETC genes in the post-mortem brains of autism patients and controls. Brain tissues from the ant
• PMID 23088660

Japanese Journal

• ヘパリン結合性上皮成長因子様成長因子の刺激誘発による切断・放出への活性酸素種の関与

• 馬田 敏幸
• 産業医科大学雑誌 36(2), 105-114, 2014-06-01
• ヘパリン結合性上皮成長因子様成長因子(HB-EGF)は,創傷治癒,動脈硬化および癌増殖など多くの生理的,病理的過程に関与している成長因子である.HB-EGFは膜型として合成され,細胞表面でプロテアーゼにより切断・放出(エクトドメインシェディング:シェディング)されて増殖活性を獲得する.この研究では,HB-EGFをサルの腎細胞に高発現させたVero-H細胞を使って,HB-EGFのシェディングヘの活性 …
• NAID 110009823329

• ヘパリン結合性上皮成長因子様成長因子の刺激誘発による切断・放出への活性酸素種の関与

• 馬田 敏幸
• Journal of UOEH 36(2), 105-114, 2014
• ヘパリン結合性上皮成長因子様成長因子（HB-EGF）は，創傷治癒，動脈硬化および癌増殖など多くの生理的，病理的過程に関与している成長因子である．HB-EGFは膜型として合成され，細胞表面でプロテアーゼにより切断・放出（エクトドメイン シェディング：シェディング）されて増殖活性を獲得する．この研究では，HB-EGFをサルの腎細胞に高発現させたVero-H細胞を使って，HB-EGFのシェディングへの活 …
• NAID 130004640675

• A Citrus Flavonoid, 6-Demethoxytangeretin, Suppresses Production and Gene Expression of Interleukin-6 in Human Mast Cell-1 via Anaplastic Lymphoma Kinase and Mitogen-Activated Protein Kinase Pathways

• , , [他], , , , , , ,
• Biological and Pharmaceutical Bulletin 37(5), 871-876, 2014
• … In order to determine the anti-allergic activity of 6-demethoxytangeretin, we examined whether or not 6-demethoxytangeretin was able to suppress activation of the human mast cell line, HMC-1, induced by phorbol 12-myristate 13-acetate (PMA) plus A23187. … Interleukin-6 production and relevant gene expression in activated HMC-1 cells were determined by enzyme-linked immunosorbent assay (ELISA) and quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis. …
• NAID 130003390983

Related Links

• MAPK13 - Mitogen-activated protein kinase 13 - Homo ...

Mitogen-activated protein kinase 13 (EC:2.7.11.24) Short name: MAP kinase 13 Short name: MAPK 13 Alternative name(s): Mitogen-activated protein kinase p38 delta Short name: MAP kinase p38 delta Stress-activated protein i i ...

• mitogen-activated protein kinase kinase kinase 13 - definition ...

mitogen-activated protein kinase 15 Mitogen-activated protein kinase 2 Mitogen-activated protein kinase 3 mitogen-activated protein kinase 4 mitogen-activated protein kinase 6 mitogen-activated protein kinase 7 mitogen-activated ...

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「マイトジェン活性化プロテインキナーゼ13」

　　[★]

英

mitogen-activated protein kinase 13

「activated」

　　[★]

• adj.

• 活性化の、活性化型の、賦活化の

関

activate、activated form、activation、turn on

　 　 　 　

「activate」

　　[★]

• v.

• 活性化する、賦活化する、賦活する

関

activated、activation、turn on

　 　 　 　 　

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「protein kinase」

　　[★] プロテインキナーゼ

同

protein kinases