細小血管障害、微小血管障害
- 関
- microangiopathy
WordNet
- an impairment of health or a condition of abnormal functioning
- caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
PrepTutorEJDIC
- (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
- 女性の話術芸人 =diseur
- 病気にかかった / 病的な,不健全な(morbid)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/12 18:00:15」(JST)
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This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (October 2013) |
| Microangiopathy |
| Classification and external resources |
| ICD-9-CM |
443.9 |
Microangiopathy (or microvascular disease, or small vessel disease) is an angiopathy (i.e.disease of blood vessels) affecting small blood vessels in the body.[1] It can be contrasted to macroangiopathy.
The term cerebral small vessel disease refers to a group of pathological processes with various aetiologies that affect the small arteries, arterioles, venules, and capillaries of the brain. Age-related and hypertension-related small vessel diseases and cerebral amyloid angiopathy are the most common forms.
Small vessel coronary disease is a type of coronary heart disease (CHD) that affects the heart's arterioles and capillaries. Small vessel coronary disease is also known as cardiac syndrome X, microvascular dysfunction, non-obstructive coronary disease, or microvascular angina.
Pathophysiology
One cause of microangiopathy is long-term diabetes mellitus. In this case, high blood glucose levels cause the endothelial cells lining the blood vessels to take in more glucose than normal (these cells do not depend on insulin). They then form more glycoproteins on their surface than normal, and also cause the basement membrane to grow thicker and weaker. The walls of the vessels become abnormally thick but weak, and therefore they bleed, leak protein, and slow the flow of blood through the body. Then some cells, for example in the retina (diabetic retinopathy) or kidney (diabetic nephropathy), may not get enough blood and may be damaged. Nerves, if not sufficiently supplied with blood, are also damaged which may lead to loss of function (diabetic neuropathy).
Massive microangiopathy may cause microangiopathic hemolytic anemia (MAHA).
References
- ^ "microangiopathy" at Dorland's Medical Dictionary
UpToDate Contents
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English Journal
- ATP-binding cassette transporters P-glycoprotein and breast cancer related protein are reduced in capillary cerebral amyloid angiopathy.
- Carrano A, Snkhchyan H, Kooij G, van der Pol S, van Horssen J, Veerhuis R, Hoozemans J, Rozemuller A, de Vries HE.Author information Department of Pathology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.AbstractAlzheimer's disease (AD) is the most common form of dementia and marked by deposition of amyloid-β (Aβ) within the brain. Alterations of Aβ transporters at the neurovasculature may play a role in the disease process. We investigated the expression of ABC transporters P-glycoprotein (P-gp) and breast cancer related protein (BCRP) in non-neurologic controls, AD, and severe capillary cerebral amyloid angiopathy (capCAA) cases, which are characterized by deposition of Aβ within cerebral capillaries. Our data show that microvascular expression of P-gp and BCRP is strikingly decreased in capCAA-affected vessels but not in AD and control samples. Messenger RNA levels of P-gp, but not of BCRP, were downregulated in brain endothelial cells on exposure to oligomeric Aβ42, but not fibrillar Aβ42 or Aβ40. Coincubating Aβ42 together with clusterin, an amyloid-associated protein highly expressed in capCAA-affected vessels, strongly reduced levels of P-gp. In conclusion, accumulation of Aβ, in combination with clusterin, within and around cerebral capillaries, may further aggravate the disease process in AD by affecting P-gp expression. Loss of P-gp expression or activity may serve as a selective biomarker for ongoing capCAA.
- Neurobiology of aging.Neurobiol Aging.2014 Mar;35(3):565-75. doi: 10.1016/j.neurobiolaging.2013.09.015. Epub 2013 Oct 15.
- Alzheimer's disease (AD) is the most common form of dementia and marked by deposition of amyloid-β (Aβ) within the brain. Alterations of Aβ transporters at the neurovasculature may play a role in the disease process. We investigated the expression of ABC transporters P-glycoprotein (P-gp) and bre
- PMID 24138987
- Novel α-galactosidase A mutation in patients with severe cardiac manifestations of Fabry disease.
- Duro G1, Musumeci MB2, Colomba P1, Zizzo C1, Albeggiani G1, Mastromarino V2, Volpe M2, Autore C3.Author information 1National Research Council, Institute of Biomedicine and Molecular Immunology "A. Monroy," 90146 Palermo, Italy.2Cardiology, Department of Clinical and Molecular Medicine, Sapienza University, 00189 Rome, Italy.3Cardiology, Department of Clinical and Molecular Medicine, Sapienza University, 00189 Rome, Italy. Electronic address: camillo.autore@uniroma1.it.AbstractFabry disease (FD) is a hereditary metabolic disorder caused by the partial or total inactivation of α-galactosidase A (α-gal A), a lysosomal hydrolase. This inactivation is responsible for the accumulation of undegraded glycosphingolipids in the lysosomes with subsequent cellular and microvascular dysfunction. Fabry is considered a rare disease, with an incidence of 1:40,000; however, there are good reasons to believe that it is often seen but rarely diagnosed. To date, more than 600 mutations have been identified in human GLA gene that are responsible for FD. We describe the case of a 54-year-old male patient, who presented with left ventricular hypertrophy, chronic renal failure and acroparaesthesias, which are considered to be specific features of FD. Clinical and instrumental investigations showed several cardiovascular manifestations. The molecular analysis of GLA gene revealed a novel mutation in the fifth exon, called N249K, and the enzymatic analysis showed no α-galactosidase A activity. Family screening detected the same mutation in some relatives and also the enzymatic analysis confirmed the diagnosis of FD. In conclusion, these data suggest that the N249K mutation may be associated with cardiac manifestations of FD combined with other classical features of the disease.
- Gene.Gene.2014 Feb 10;535(2):365-9. doi: 10.1016/j.gene.2013.09.058. Epub 2013 Oct 17.
- Fabry disease (FD) is a hereditary metabolic disorder caused by the partial or total inactivation of α-galactosidase A (α-gal A), a lysosomal hydrolase. This inactivation is responsible for the accumulation of undegraded glycosphingolipids in the lysosomes with subsequent cellular and microvascula
- PMID 24140492
- Hepatitis B virus-related combined hepatocellular-cholangiocarcinoma: clinicopathological and prognostic analysis of 390 cases.
- Chu KJ, Lu CD, Dong H, Fu XH, Zhang HW, Yao XP.Author information aDepartment VI of Hepatic Surgery bDepartment of Pathology, Eastern Hepatobiliary Surgical Hospital cDepartment of Epidemiology, Faculty of Health Service, Second Military Medical University, Shanghai, China.AbstractBACKGROUND: The reported treatment outcomes of combined hepatocellular-cholangiocarcinoma (HCC-CC) are inconsistent and the clinicopathological factors influencing treatment outcome remain to be defined.
- European journal of gastroenterology & hepatology.Eur J Gastroenterol Hepatol.2014 Feb;26(2):192-9. doi: 10.1097/MEG.0b013e3283625df9.
- BACKGROUND: The reported treatment outcomes of combined hepatocellular-cholangiocarcinoma (HCC-CC) are inconsistent and the clinicopathological factors influencing treatment outcome remain to be defined.PATIENTS AND METHODS: Patients with hepatitis B virus (HBV)-related HCC-CC undergoing surgical tr
- PMID 24370644
Japanese Journal
- Clinical Spectrum and Outcome of Patients With Non-ST-Segment Elevation Acute Coronary Syndrome and No Obstructive Coronary Atherosclerosis
- Epicardial Artery Stenosis with a High Index of Microcirculatory Resistance Is Frequently Functionally Insignificant as Estimated by Fractional Flow Reserve (FFR)
- 虚血性心疾患 (特集 性差医療の最前線 : 生活習慣病を中心に) -- (性差を考慮すべき疾患)
Related Links
- Overview Both men and women who have coronary microvascular disease often have diabetes or high blood pressure. Some people who have coronary microvascular disease may have inherited heart muscle diseases. Diagnosing ...
- The American Heart Association explains coronary microvascular disease or MVD. ... What Is Coronary Microvascular Disease (MVD)? Coronary microvascular disease (sometimes called small artery disease or small vessel ...
★リンクテーブル★
[★]
- 英
- microangiopathy, microvascular disease
- 同？
- 微小血管症、細小血管症、細小血管障害
[show details]
[★]
- 英
- microvascular disease
- 関
- 微小血管障害
[★]
- 疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
- 特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
- something that is very wrong with people's attitudes, way of life or with society.
- 関
- ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness
- disease ≠ illness ≠ disorder
[★]
- 関
- microvessel