WordNet

(ecology) the status of an organism within its environment and community (affecting its survival as a species) (同)ecological_niche
a position particularly well suited to the person who occupies it; "he found his niche in the academic world"

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1. 造血および幹細胞の機能の概要 overview of hematopoiesis and stem cell function
2. 慢性リンパ性白血病の病態生理および遺伝学的特徴 pathophysiology and genetic features of chronic lymphocytic leukemia
3. 胃癌の病理および分子学的病因 pathology and molecular pathogenesis of gastric cancer
4. 慢性骨髄単球性白血病 chronic myelomonocytic leukemia
5. 濾胞性リンパ腫の臨床症状、病理学的特徴、診断、および予後 clinical manifestations pathologic features diagnosis and prognosis of follicular lymphoma

The increased binding affinity of curcumin with human serum albumin in the presence of rutin and baicalin: A potential for drug delivery system.

Liu BM1, Zhang J2, Hao AJ2, Xu L2, Wang D2, Ji H2, Sun SJ2, Chen BQ2, Liu B3.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2016 Feb 15;155:88-94. doi: 10.1016/j.saa.2015.11.010. Epub 2015 Nov 7.
The impacts of rutin and baicalin on the interaction of curcumin (CU) with human serum albumin (HSA) were investigated by fluorescence and circular dichroism (CD) spectroscopies under imitated physiological conditions. The results showed that the fluorescence quenching of HSA by CU was a simultaneou
PMID 26583522

Cellular and Molecular Mechanisms of Phenotypic Switch in Gastrointestinal Smooth Muscle.

Scirocco A1, Matarrese P2,3, Carabotti M1, Ascione B2, Malorni W2,4, Severi C1.
Journal of cellular physiology.J Cell Physiol.2016 Feb;231(2):295-302. doi: 10.1002/jcp.25105.
As a general rule, smooth muscle cells (SMC) are able to switch from a contractile phenotype to a less mature synthetic phenotype. This switch is accompanied by a loss of differentiation with decreased expression of contractile markers, increased proliferation as well as the synthesis and the releas
PMID 26206426

Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/β-catenin signaling.

Martins-Neves SR1, Paiva-Oliveira DI2, Wijers-Koster PM3, Abrunhosa AJ4, Fontes-Ribeiro C5, Bovée JV3, Cleton-Jansen AM3, Gomes CM6.
Cancer letters.Cancer Lett.2016 Jan 28;370(2):286-95. doi: 10.1016/j.canlet.2015.11.013. Epub 2015 Nov 11.
Development of resistance represents a major drawback in osteosarcoma treatment, despite improvements in overall survival. Treatment failure and tumor progression have been attributed to pre-existing drug-resistant clones commonly assigned to a cancer stem-like phenotype. Evidence suggests that non
PMID 26577806

Therapeutic Targeting of Microenvironmental Interactions in Leukemia : Mechanisms and Approaches

Therapeutic Targeting of Microenvironmental Interactions in Leukemia:Mechanisms and Approaches

TABE YOKO
順天堂醫事雑誌 60(2), 156-160, 2014
Bone marrow (BM) microenvironment plays a critical role in the process of leukemogenesis with the dynamic interactions between leukemic cells and cells of the bone marrow microenvironment. In the BM m …
NAID 130004684334

小坂展慶,落谷孝広
Drug Delivery System 29(2), 125-133, 2014
がん細胞とその周辺細胞の密接な関係は、これまでサイトカインやケモカインなどで説明されてきた。しかし、その複雑な関係は複数種類の分子では説明がつかず、新たな相互関係が探索されてきた。最近、エクソソームと呼ばれる100nmの細胞外小胞顆粒の存在が再注目され、特に、がん細胞における役割が近年急速に解明されている。本稿では、がん細胞がどのようにしてエクソソームを悪用しているのかを述べるとともに、エクソソー …
NAID 130004495149