WordNet

a crystalline amino acid containing sulfur; found in most proteins and essential for nutrition
abnormal absorption of nutrients from the digestive tract

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1. ビタミンB12および葉酸欠乏症の病因および臨床症状 etiology and clinical manifestations of vitamin b12 and folate deficiency
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4. 疾患予防におけるビタミン補給 vitamin supplementation in disease prevention
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Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia.

Hung CH1, Chan SH2, Chu PM3, Tsai KL4.
Clinical science (London, England : 1979).Clin Sci (Lond).2015 Sep;129(6):477-87. doi: 10.1042/CS20150127. Epub 2015 May 18.
HHcy (hyperhomocysteinaemia) is one of the major risk factors for cardiovascular diseases. A high concentration of Hcy (homocysteine) induces endothelial dysfunction by activating endothelial oxidative stress. LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1) plays a vital role in regu
PMID 25982096

Hyperhomocysteinemia suppresses bone marrow CD34+/VEGF receptor 2+ cells and inhibits progenitor cell mobilization and homing to injured vasculature-a role of β1-integrin in progenitor cell migration and adhesion.

Nelson J1, Wu Y1, Jiang X1, Berretta R1, Houser S1, Choi E1, Wang J1, Huang J1, Yang X1, Wang H2.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2015 Jul;29(7):3085-99. doi: 10.1096/fj.14-267989. Epub 2015 Apr 8.
Hyperhomocysteinemia (HHcy) impairs re-endothelialization and accelerates vascular remodeling. The role of CD34(+)/VEGF receptor (VEGFR) 2(+) progenitor cells (PCs) in vascular repair in HHcy is unknown. We studied the effect of HHcy on PCs and its role in vascular repair in severe HHcy (∼150 μM)
PMID 25854700

石川真紀子,清水順也,金谷誠久,白神浩史,久保俊英,中原康雄,後藤隆文
Nihon Shoni Jinzobyo Gakkai Zasshi 24(2), 224-229, 2011
　シスチン尿症は腎尿細管，小腸上皮におけるシスチンと二塩基性アミノ酸の吸収障害を本態とする疾患であり，尿路結石の頻回再発やそれに伴う腎不全への進展が問題となる。症例は，結石分析，尿中アミノ酸分析にてシスチン尿症と診断し，重曹による尿アルカリ化治療を行っていた2歳男児である。定期受診時に，顕微鏡的血尿と，超音波および腹部CTにて左水腎水尿管と左膀胱尿管移行部に巨大結石を認めた。体外衝撃波結石破砕術は …
NAID 130002114190