WordNet

the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion
insoluble pigments that account for the color of e.g. skin and scales and feathers

PrepTutorEJDIC

ホルモン
メラニン(皮膚・毛髪などに見られる黒色色素)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/30 11:28:41」(JST)

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Melanin-concentrating hormone (MCH) is a cyclic 19-amino acid orexigenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish where it controls skin pigmentation.

In mammals it is involved in the regulation of feeding behavior, mood, sleep-wake cycle^[1] and energy balance. MCH expressing neurons are located within the lateral hypothalamus and zona incerta. Despite this restricted distribution MCH neurons project widely throughout the brain. MCH knockout mice are hypophagic (eat less) and are lean. When administered centrally it increases food intake and weight gain.

References

^ Verret L, Goutagny R, Fort P, Cagnon L, Salvert D, Léger L, Boissard R, Salin P, Peyron C, Luppi PH. (2003). "A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep". BMC Neurosci 4 (19). doi:10.1186/1471-2202-4-19. PMID 12964948.

External links

Melanin-concentrating hormone at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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2. 肥満の病因 pathogenesis of obesity
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English Journal

Fighting Obesity with a Sugar-Based Library: Discovery of Novel MCH-1R Antagonists by a New Computational-VAST Approach for Exploration of GPCR Binding Sites.

Heifetz A, Barker O, Verquin GP, Wimmer N, Meutermans W, Pal S, Law RJ, Whittaker M.AbstractObesity is an increasingly common disease. While antagonism of the melanin-concentrating hormone-1 receptor (MCH-1R) has been widely reported as a promising therapeutic avenue for obesity treatment, no MCH-1R antagonists have reached the market. Discovery and optimization of new chemical matter targeting MCH-1R is hindered by reduced HTS success rates and a lack of structural information about the MCH-1R binding site. X-ray crystallography and NMR, the major experimental sources of structural information, are very slow processes for membrane proteins, and are not currently feasible for every GPCR or GPCR-ligand complex. This situation significantly limits the ability of these methods to impact the drug discovery process for GPCR targets in "real-time" and hence there is an urgent need for other practical and cost-efficient alternatives. We present here a conceptually pioneering approach that integrates GPCR modeling with design, synthesis and screening of a diverse library of sugar-based compounds from the VAST technology (Versatile Assembly on Stable Templates), to provide structural insights on the MCH-1R binding site. This approach creates a cost-efficient new avenue for structure-based drug discovery (SBDD) against GPCR targets. In our work, a primary VAST hit was used to construct a high-quality MCH-1R model. Following model validation, a structure-based virtual screen yielded a 14% hit rate and 10 novel chemotypes of potent MCH-1R antagonists, including EOAI3367472 (IC50 = 131 nM) and EOAI3367474 (IC50 = 213 nM).
Journal of chemical information and modeling.J Chem Inf Model.2013 Apr 16. [Epub ahead of print]
Obesity is an increasingly common disease. While antagonism of the melanin-concentrating hormone-1 receptor (MCH-1R) has been widely reported as a promising therapeutic avenue for obesity treatment, no MCH-1R antagonists have reached the market. Discovery and optimization of new chemical matter targ
PMID 23590178

Lateral hypothalamus as a sensor-regulator in respiratory and metabolic control.

Burdakov D, Karnani MM, Gonzalez A.SourceKing's College London, MRC Center for Developmental Neurobiology, London, UK; MRC National Institute for Medical Research, London, UK. Electronic address: denis.burdakov@kcl.ac.uk.
Physiology & behavior.Physiol Behav.2013 Apr 3. pii: S0031-9384(13)00099-1. doi: 10.1016/j.physbeh.2013.03.023. [Epub ahead of print]
Physiological fluctuations in the levels of hormones, nutrients, and gasses are sensed in parallel by interacting control systems distributed throughout the brain and body. We discuss the logic of this arrangement and the definitions of "sensing"; and then focus on lateral hypothalamic (LH) control
PMID 23562864

Japanese Journal

Synthesis and Structure-Activity Relationship of Naphtho[1,2-b]furan-2-carboxamide Derivatives as Melanin Concentrating Hormone Receptor 1 Antagonists

Lim Chae Jo,Choi Jun Young,Lee Byung Ho [他]
Chemical and pharmaceutical bulletin 61(12), 1239-1247, 2013-12
NAID 40019889786

Developmental changes in melanophores and their asymmetrical responsiveness to melanin-concentrating hormone during metamorphosis in barfin flounder (Verasper moseri).

Yoshikawa Naoki,Matsuda Taihei,Takahashi Akiyoshi,Tagawa Masatomo
General and comparative endocrinology 194, 118-123, 2013-09-21
… In this study, we first assessed the changes in melanophores with development and then investigated their responsiveness to melanin-concentrating hormone (MCH) during metamorphosis. …
NAID 120005341898

Related Pictures

★リンクテーブル★

リンク元	「MCH」「メラニン凝集ホルモン」

「MCH」

Melanin-concentrating hormone
Identifiers
Symbol	PMCH
CAS number	67382-96-1
Entrez	5367
HUGO	9109
OMIM	176795
RefSeq	NM_002674
UniProt	P20382
Other data
Locus	Chr. 12 q23.2