マイタンシン、メイタンシン
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/15 21:20:10」(JST)
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Maitansine
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Names |
Other names
Maytansin
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Identifiers |
CAS Registry Number
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35846-53-8 Y |
ChEBI |
CHEBI:6701 N |
ChEMBL |
ChEMBL488931 N |
Jmol-3D images |
Image |
PubChem |
5281828 |
SMILES
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C/C(CC1=CC(OC)=C(Cl)C(N3C)=C1)=C\C=C\[C@@H](OC)[C@@]2(O)C[C@]([C@@H](C)[C@H]4[C@](O4)(C)[C@@H](OC([C@H](C)N(C)C(C)=O)=O)CC3=O)([H])OC(N2)=O
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UNII |
14083FR882 N |
Properties |
Chemical formula
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C34H46ClN3O10 |
Molar mass |
692.20 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N verify (what is: Y/N?) |
Infobox references |
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Maitansine (INN), or maytansine (USAN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.[1]
It is a macrolide of the ansamycin type and can be isolated from plants of the genus Maytenus.[1]
Derivatives are known as maytansinoids.[2]
See also
References
- ^ a b National Cancer Institute: Definition of Maytansine
- ^ Yu, T.-W.; Bai, L; Clade, D; Hoffmann, D; Toelzer, S; Trinh, KQ; Xu, J; Moss, SJ; Leistner, E (2002). "The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnemapretiosum". Proceedings of the National Academy of Sciences 99 (12): 7968–7973. doi:10.1073/pnas.092697199. PMC 123004. PMID 12060743.
UpToDate Contents
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English Journal
- Spatial profiling of maytansine during the germination process of Maytenus senegalensis seeds.
- Eckelmann D1, Kusari S2, Spiteller M3.
- Fitoterapia.Fitoterapia.2017 Jun;119:51-56. doi: 10.1016/j.fitote.2017.03.014. Epub 2017 Apr 3.
- PMID 28385670
- T-DM1 in the Neo-Adjuvant Treatment of HER2-Positive Breast Cancer: Impact of the KRISTINE (TRIO-021) Trial.
- Okines AF1.
- Reviews on recent clinical trials.Rev Recent Clin Trials.2017 May 28. doi: 10.2174/1574887112666170529094911. [Epub ahead of print]
- PMID 28552047
- Antibody-Drug Conjugates (ADCs) for Personalized Treatment of Solid Tumors: A Review.
- Lambert JM1, Morris CQ2.
- Advances in therapy.Adv Ther.2017 May;34(5):1015-1035. doi: 10.1007/s12325-017-0519-6. Epub 2017 Mar 30.
- PMID 28361465
Japanese Journal
- 抗体薬物複合体の臨床開発 (特集 抗体デリバリー : 基礎から臨床まで)
- Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System 28(5), 424-429, 2013-11
- NAID 40019893952
- Cytotoxic Activity of Maytanprine Isolated from Maytenus diversifolia in Human Leukemia K562 Cells
Related Links
- maytansine An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly ...
- Maytansine, a benzoansamacrolide, is a potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations ... References [1] Lopus M, Oroudjev E, Wilson L, Wilhelm S ...
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