関: malacoplakia

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/02 22:21:47」(JST)

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Malakoplakia or malacoplakia (from Greek Malako "soft" + Plako "plaque") is a rare inflammatory condition which makes its presence known as a papule, plaque or ulceration that usually affects the genitourinary tract.^[1]^:274 However, it may also be associated with other bodily organs. It was initially described in the early 20th century as soft yellowish plaques found on the mucosa of the urinary bladder. Microscopically it is characterized by the presence of foamy histiocytes with basophilic inclusions called Michaelis–Gutmann bodies.

It usually involves gram negative bacteria.^[2]

Causes

Malakoplakia is thought to result from the insufficient killing of bacteria by macrophages. Therefore, the partially digested bacteria accumulate in macrophages and leads to a deposition of iron and calcium. The impairment of bactericidal activity manifests itself as the formation of an ulcer, plaque or papule.

Malakoplakia is associated with patients with a history of immunosuppression due to lymphoma, diabetes mellitus, renal transplantation, or because of long-term therapy with systemic corticosteroids.

Treatment

Today, antibiotics are used for treatment of malakoplakia.

References

^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
^ Liang Cheng; David G. Bostwick (2006). Essentials of anatomic pathology. Springer. pp. 1180–. ISBN 978-1-58829-461-6. Retrieved 15 May 2010.

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English Journal

Rectosigmoid malakoplakia.

Yen JM1, Soh NWY1, Petersson F2, Pandya G1.
BMJ case reports.BMJ Case Rep.2017 May 31;2017. pii: bcr-2017-219464. doi: 10.1136/bcr-2017-219464.
PMID 28566412

Malakoplakia after kidney transplantation: Case report and literature review.

Nieto-Ríos JF1, Ramírez I2, Zuluaga-Quintero M3, Serna-Higuita LM1, Gaviria-Gil F4, Velez-Hoyos A5.
Transplant infectious disease : an official journal of the Transplantation Society.Transpl Infect Dis.2017 May 31. doi: 10.1111/tid.12731. [Epub ahead of print]
PMID 28561517

Granulomatous & histiocytic dermatitides.

Wick MR1.
Seminars in diagnostic pathology.Semin Diagn Pathol.2017 May;34(3):301-311. doi: 10.1053/j.semdp.2016.12.003. Epub 2016 Dec 14.
PMID 28094163

Japanese Journal

子宮内膜に発症したマラコプラキアの1例

日本臨床細胞学会雑誌 52(2), 139-142, 2013-03-22
NAID 10031138847

Granulomatous Nephritis Consistent with Malakoplakia in a Cynomolgus Monkey

Journal of Toxicologic Pathology 26(4), 419-422, 2013
NAID 130003382460

膀胱に発生したmalakoplakiaの1例 : 病理学的観察を中心として

産業医科大学雑誌 34(3), 265-270, 2012-09-01
NAID 110009495739

「マラコプラキア」

Malakoplakia
	Micrograph showing the characteristic finding of malakoplakia (Michaelis–Gutmann bodies). H&E stain.
Classification and external resources
DiseasesDB	29128
eMedicine	derm/872
MeSH	D008287
Orphanet	556
	[edit on Wikidata]

　　[★]

英: malacoplakia、malakoplakia
同: 軟斑性膀胱カタル
関: 膀胱マラコプラキア vesical malacoplakia

「malakoplakia of urinary bladder」

　　[★] 膀胱マラコプラキア

[Andrews-1] James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.

[ChengBostwick2006-2] Liang Cheng; David G. Bostwick (2006). Essentials of anatomic pathology. Springer. pp. 1180–. ISBN 978-1-58829-461-6. Retrieved 15 May 2010.

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malakoplakia