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1. 自然免疫系の概要an overview of the innate immune system [show details]
… alpha- and beta-defensins: Human alpha-defensins 1 to 4 (HDs 1 to 4) are contained in the azurophilic granules of neutrophils and are also synthesized by… It has antimicrobial capacity against iron-dependent organisms such as malaria, tuberculosis, and human immunodeficiency virus-1 (HIV-1) .…
2. 好中球増多症の患者へのアプローチapproach to the patient with neutrophilia [show details]
… marrow. Proliferation of neutrophil precursors, the process of myeloid differentiation, and entry of these cells into the circulation are tightly regulated by cytokines and are dependent on orderly control of …
3. 好中球機能異常症の検査での評価laboratory evaluation of neutrophil disorders [show details]
… The polymorphonuclear neutrophil (PMN) is the primary defense against bacterial and fungal invasion. Defects of neutrophil number and function commonly present with recurrent and severe bacterial and …
4. 貧食細胞数と機能の原発性異常：概要primary disorders of phagocyte number and or function an overview [show details]
… SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily D, member 2 (SMARCD2) genes. The diagnosis is made by examining neutrophils in a peripheral blood smear for the pathognomonic …
5. 化学療法による好中球減少症を有する成人患者と、急性白血病、骨髄異形成症候群、造血細胞移植以外の病態を有する成人患者における顆粒球コロニー刺激因子の利用use of granulocyte colony stimulating factors in adult patients with chemotherapy induced neutropenia and conditions other than acute leukemia myelodysplastic syndrome and hematopoietic cell transplantation [show details]
…to decrease infectious complications, recombinant human granulocyte colony stimulating factor (G-CSF; filgrastim and pegylated filgrastim) and granulocyte-macrophage colony stimulating factor (GM-CSF; sargramostim) …

English Journal

UHPLC-DAD-ESI-MS/MS and HPTLC profiling of ash leaf samples from different commercial and natural sources and their in vitro effects on mediators of inflammation.

Kiss AK, Michalak B, Patyra A, Majdan M.
Phytochemical analysis : PCA. 2020 Jan;31(1)57-67.
In European traditional medicine, common ash leaf infusion is recommended by European Medicines Agency to treat minor articular pain and to increase the amount of urine for flushing minor urinary complaints. However, a comprehensive ultra-high-performance liquid chromatography diode array detector e
PMID 31286597

[Immunomodulating activity of adhesive dental film containing chlorhexidine and ketoprofen in serum of patients with chronic periodontitis].

Ushakov RV, Gerasimova TP, Nikolaev VA.
Stomatologiia. 2019 ;98(5)6-10.
The study was carried out in series of preclinical tests of new adhesive dental film developed for local treatment of inflammatory periodontal disease and containing chlorhexidine bigluconate and ketoprofen. The aim of the work was to determine film's effect on the activity of blood neutrophils in h
PMID 31701922

The influence of procyanidins isolated from small-leaved lime flowers (Tilia cordata Mill.) on human neutrophils.

Czerwińska ME, Dudek MK, Pawłowska KA, Pruś A, Ziaja M, Granica S.
Fitoterapia. 2018 Jun;127()115-122.
Linden flower is a wildly used plant material among patients in the treatment of common cold symptoms and mucosa inflammations. However, the structure and bioactivity of flavan-3-ol derivatives present in infusions from flowers of Tilia cordata have not been studied so far. The aim of current study
PMID 29447978

Japanese Journal

新規好中球機能検査法を応用した植物抽出物の機能性評価

鈴木克彦,駒場優太,泊美樹 [他],鈴木洋子,菅間薫,高橋将記,三浦茂樹,吉岡浩,森有一
日本補完代替医療学会誌 9(2), 89-95, 2012
今日，活性酸素の身体への影響は重大な関心事となっている．活性酸素の過剰産生は酸化ストレスとなり，生活習慣病や発がんに関与するとされている．一方，抗酸化作用を有する様々な健康食品が普及しているが，より生体に近い条件での機能性評価法が求められている．そこで本研究では，新規好中球機能検査法を用いて植物抽出物の抗酸化作用を比較検討した．植物抽出物には，レモンバーベナ抽出物，緑茶抽出物，ツバキ種子抽出物，ア …
NAID 130001924036

MECHANISTIC APPROACH TO THE EFFECTS OF LOW LEVEL LASER IRRADIATION (LLLI) WITH THE GaAlAs DIODE LASER ON THE PRODUCTION OF REACTIVE OXYGEN SPECIES FROM HUMAN NEUTROPHILS AS A MODEL FOR THERAPEUTIC MODALITY AT A CELLULAR LEVEL

Suzuki Koh-Jun,Takahashi Ippei,Kumae Takashi,Nakaji Shigeyuki,Kogawa Terumi,Kumeta Keiko,Oka Eiko,Kitagawa Naoko,Suzukawa Kazuhiro,Tsushima Eiki,Nakayama Teiichi
レーザーセラピー 14(2), 75-81, 2005
… There have been many reports on the applications of low reactive level laser therapy (LLLT) for pain attenuation or pain removal. …
NAID 130004553621

Characteristics of Attenuating Effects of Rebamipide, an Anti-ulcer Agent, on Oxidative Burst of Human Neutrophils

Shimoyama Tadashi,Fukuda Shinsaku,Liu Qiang [他],FUKUDA Yoshihiro,NAKAJI Shigeyuki,SUGAWARA Kazuo
Journal of
… The aim of this study was to characterize the effects of rebamipide on the oxidative burst of human neutrophils. … The neutrophil oxidative burst was measured in the presence of rebamipide and cimetidine using lucigenin- or luminol-dependent chemiluminescence (LgCL or LmCL). …
NAID 130000073718