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1. 肝細胞癌に対する治療法の概要overview of treatment approaches for hepatocellular carcinoma [show details]
…locoregional liver-directed therapy, additional liver-directed therapy might be possible depending upon tumor location and underlying liver function. However, the benefit of additional locoregional therapy versus… these results support the general principle that locoregional forms of therapy, such as radioembolization, are preferable to systemic therapy alone for initial treatment of patients with…
2. アルコール使用障害への治療アプローチapproach to treating alcohol use disorder [show details]
…preference and treatment availability may be overriding factors in selecting a treatment modality for many patients. While clinical trials support the efficacy of psychosocial interventions compared… and treatment goals, can influence the choice of medication for alcohol use disorder. For medication treatment of alcohol use disorder in patients with acute hepatitis, liver enzymes…
3. 原発性胆汁性胆管炎（原発性胆汁性肝硬変）の治療の概要overview of the treatment of primary biliary cholangitis primary biliary cirrhosis [show details]
… other causes of liver failure. Fatigue is common in patients with PBC and can be severely debilitating. However, there is no recommended therapy for treating fatigue,… evidence to support this approach is limited. The use of UDCA in the treatment of PBC and its mechanism of action…
4. B型肝炎ウイルス：マネージメントの概要hepatitis b virus overview of management [show details]
… Patients with life-threatening liver disease secondary to HBV should initiate antiviral therapy. This includes patients with acute liver failure (eg,… Treatment with nucleos(t)ide analogues can reduce the risk of recurrence and improve the prognosis of HBV-related HCC after curative therapy. This approach was supported in a meta-analysis…
5. アルコール性肝疾患の病因pathogenesis of alcoholic liver disease [show details]
… composition of the hepatic scar is similar in all forms of fibrosing liver injury, supporting the concept that the fundamental response of the liver to injury is similar whether due to alcohol, drugs, viral infection …

English Journal

Adverse reactions associated with long-term drug administration in complex lung disease.

Kamii Y, Nagai H, Kawashima M, Matsuki M, Nagoshi S, Sato A, Kohno S, Ohgiya M, Ohta K.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 2018 12;22(12)1505-1510.
The number of patients with non-tuberculous mycobacterial lung disease (NTM-LD) worldwide has been increasing. complex lung disease (MAC-LD) accounts for 90% of NTM-LD. MAC-LD necessitates long-term treatment, but adverse reactions with long-term administration of drugs are poorly understood. To ev
PMID 30606324

Acute-on-chronic liver failure in chronic hepatitis B: an update.

Zhao RH, Shi Y, Zhao H, Wu W, Sheng JF.
Expert review of gastroenterology & hepatology. 2018 Apr;12(4)341-350.
Acute-on-chronic liver failure is a common pattern of end-stage liver disease in clinical practice and occurs frequently in patients with chronic hepatitis B or HBV-related cirrhosis. New progress in recent years leads to a better understanding of this disease. Areas covered: This review updates the
PMID 29334786

Eribulin-induced liver dysfunction as a prognostic indicator of survival of metastatic breast cancer patients: a retrospective study.

Kobayashi T, Tomomatsu J, Fukada I, Shibayama T, Teruya N, Ito Y, Iwase T, Ohno S, Takahashi S.
BMC cancer. 2016 07;16()404.
Eribulin is a non-taxane, microtubule dynamics inhibitor that increases survival of patients with metastatic breast cancer. Although eribulin is well tolerated in patients with heavily pretreated disease, eribulin-induced liver dysfunction (EILD) can occur, resulting in treatment modification and su
PMID 27389013

Japanese Journal

腹腔鏡下肝切除術を施行した肝細胞癌との鑑別が困難であった大型再生結節（LRN）の1例

中島隆善,村田佳津子,真鍋隆夫 [他],福島裕子,井上健,塚本忠司,金沢景繁,清水貞利,栄政之,中井隆志,川崎靖子,木岡清英,甲田洋一
肝臓 55(7), 384-391, 2014
症例は40歳，女性．2005年よりC型慢性肝炎に対してPEG-IFNα-2b・Ribavirin併用療法を施行．一旦はSVRとなったが2006年に再燃．その後に副作用の懸念などから肝庇護療法のみが行われていた．経過観察中の2010年に腹部dynamic CTにて肝S3辺縁に径2 cm大の単純で低濃度で，明らかな動脈性濃染を示さず，平衡相でも低濃度の病変を認めた．同病変はMRIではT1-FFE法によ …
NAID 130004678873

集中治療を必要とした周産期重症患者の検討

下村俊行,上田康晴,呉原弘吉,岩阪友俗,福島哲志
奈良医学雑誌 45(6), 659-664, 1994-12-31
… pulmonary edema，HELLP syndrome (syndrome of hemolysis，elevated liver enzymes，and low platelet count)，eclampsia，eclampsia with HELLP syndrome. … The patients suffering from hemorrhagic shock were intensively treated with blood transfusion，platelet-infusion and anticoagulation therapy ; … also for the patients of eclampsia，anticoagulation therapy and vasodilation therapy were employed for hemodynamic stability. …
NAID 120004973547