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1. 成人に生じる胆石症の概要overview of gallstone disease in adults [show details]
…gallbladder as rapidly as gravel . The sludge seen on ultrasound represents microlithiasis (lithogenic bile that contains cholesterol monohydrate crystals, bilirubin granules, and a mucus glycoprotein …
2. 嚢胞性線維症：臨床症状および診断cystic fibrosis clinical manifestations and diagnosis [show details]
…to 12 percent of patients, which may result from excessive loss of bile acids in the stool with consequent production of lithogenic bile . Asymptomatic cholelithiasis generally does not require treatment …
3. 嚢胞性線維症：肝胆道系疾患cystic fibrosis hepatobiliary disease [show details]
…up to 12 percent of patients and may result from excessive loss of bile acids in the stool with consequent production of lithogenic bile . Asymptomatic cholelithiasis generally does not require treatment …
4. 総胆管結石の手術surgical common bile duct exploration [show details]
… 5-0 monofilament absorbable sutures. Absorbable sutures should be used in the bile duct since permanent suture is lithogenic . Compared with T-tube closure, primary closure is associated with decreased …
5. 胆管切除術および再建術bile duct resection and reconstruction [show details]
…be discussed here. The management of common bile duct stone and bile duct injury, and surgical treatment of cholangiocarcinoma, are covered elsewhere. Bile duct resection and reconstruction (BDRR) is …

English Journal

Cholesterol cholelithiasis: part of a systemic metabolic disease, prone to primary prevention.

Di Ciaula A, Wang DQ, Portincasa P.
Expert review of gastroenterology & hepatology. 2019 Feb;13(2)157-171.
Cholesterol gallstone disease have relationships with various conditions linked with insulin resistance, but also with heart disease, atherosclerosis, and cancer. These associations derive from mechanisms active at a local (i.e. gallbladder, bile) and a systemic level and are involved in inflammatio
PMID 30791781

Protective Effects of Yinchenhao Decoction on Cholesterol Gallstone in Mice Fed a Lithogenic Diet by Regulating LXR, CYP7A1, CYP7B1, and HMGCR Pathways.

Meng Y, Meng K, Zhao X, Li D, Gao Q, Wu S, Cui Y.
Evidence-based complementary and alternative medicine : eCAM. 2018 ;2018()8134918.
The study attempted to elucidate whether lipid genes are closely associated with lipid metabolic abnormalities during the lithogenic time and how Yinchenhao Decoction (YCHD) works on the transcriptions of lipid genes against cholesterol gallstone model. C57BL/6J mice fed on lithogenic diet (LD) were
PMID 30310412

Peroxisome Proliferator-Activated Receptor- Prevents Cholesterol Gallstone Formation in C57bl Mice by Regulating Bile Acid Synthesis and Enterohepatic Circulation.

Wang G, Han T, Wang S, Chen M, Sun Y, Fu Z.
BioMed research international. 2018 ;2018()7475626.
To investigate the role of the peroxisome proliferator-activated receptor- (PPAR) in the progression of cholesterol gallstone disease (CGD), C57bl/6J mice were randomized to the following groups (n=7/group): L (lithogenic diet, LGD), LM (LGD+pioglitazone), CM (chow diet+pioglitazone), and NC (normal
PMID 30105244

Japanese Journal

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression

Kikuchi Takuya,Orihara Kana,Oikawa Fusaka,Han Song-iee,Kuba Motoko,Okuda Kanako,Satoh Aoi,Osaki Yoshinori,Takeuchi Yoshinori,Aita Yuichi,Matsuzaka Takashi,Iwasaki Hitoshi,Yatoh Shigeru,Sekiya Motohiro,Yahagi Naoya,Suzuki Hiroaki,Sone Hirohito,Nakagawa Yoshimi,Yamada Nobuhiro,Shimano Hitoshi
Molecular mtabolism 5(11), 1092-1102, 2016-11
… unknown.MethodsTo investigate the influence of intestinal CREBH on cholesterol metabolism, we compared plasma, bile, fecal, and tissue cholesterol levels between wild-type (WT) mice and mice overexpressing active human CREBH mainly in the small intestine (CREBH Tg mice) under different dietary conditions.ResultsPlasma cholesterol, hepatic lipid, and cholesterol crystal formation in the gallbladder were lower in CREBH Tg mice fed a lithogenic diet (LD) than in LD-fed WTs, while fecal cholesterol output was higher in the …
NAID 120005893691

ペクチンのコレステロール無添加飼料を与えられた胃切除ラットの胆汁の胆石形成指標への影響

宮田富弘,中島昭,海老原清
日本食物繊維研究会誌 6(1), 9-16, 2002-06
NAID 40005570892

ペクチンのコレステロール無添加飼料を与えられた胃切除ラットの胆汁の胆石形成指標への影響

宮田富弘,中島昭,海老原清
日本食物繊維研究会誌 6(1), 9-16, 2002
この研究では胃全摘出ラットの胆汁のコレステロール飽和度に及ぼすペクチンの影響を調べた。ラットをペクチン無添加飼料を与えた擬手術ラット、ペクチン無添加飼料を与えた胃全摘出ラット、ペクチン(5%)添加飼料を与えた胃全摘出ラットの3群に分け、70日間それぞれの実験飼料を与えた。ペクチン無添加飼料を与えた群間の比較では,胆汁流量,胆汁酸,コレステロールおよびリン脂質の胆汁中分泌速度,胆汁中のコール酸の割合 …
NAID 130004325851