UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

Efficient double-stranded RNA production methods for utilization in plant virus control.

Voloudakis AE1, Holeva MC, Sarin LP, Bamford DH, Vargas M, Poranen MM, Tenllado F.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2015;1236:255-74. doi: 10.1007/978-1-4939-1743-3_19.
Double-stranded RNA (dsRNA) is an inducer molecule of the RNA silencing (RNA interference, RNAi) pathway that is present in all higher eukaryotes and controls gene expression at the posttranscriptional level. This mechanism allows the cell to recognize aberrant genetic material in a highly sequence
PMID 25287509

New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase.

Wei Z1, Liu YQ2, Zhou XB1, Luo Y2, Huang CQ2, Wang YA2, Zheng ZB3, Li S1.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2014 Dec 15;24(24):5743-8. doi: 10.1016/j.bmcl.2014.10.055. Epub 2014 Oct 22.
Herein, we described a new class of uncharged non-pyridinium reactivators for nerve agent-inhibited acetylcholinesterase (AChE). Based on a dual site binding strategy, we conjugated the imidazolium aldoxime to different peripheral site ligands (PSLs) of AChE through alkyl chains. Compared with the k
PMID 25453812

A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides.

Wilhelm CM1, Snider TH2, Babin MC3, Jett DA4, Platoff GE Jr5, Yeung DT6.
Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2014 Dec 15;281(3):254-65. doi: 10.1016/j.taap.2014.10.009. Epub 2014 Oct 31.
The currently fielded pre-hospital therapeutic regimen for the treatment of organophosphorus (OP) poisoning in the United States (U.S.) is the administration of atropine in combination with an oxime antidote (2-PAM Cl) to reactivate inhibited acetylcholinesterase (AChE). Depending on clinical sympto
PMID 25448441