関: N-isopropyl-p-iodoamphetamine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/22 09:43:47」(JST)

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Iofetamine (¹²³I) (INN; brand names Perfusamine, SPECTamine), or N-isopropyl-(¹²³I)-p-iodoamphetamine (IMP), is a lipid-soluble amine and radiopharmaceutical drug used in cerebral blood perfusion imaging with single photon emission computed tomography (SPECT).^[1]^[2]^[3] Labeled with the radioactive isotope iodine-123, it is approved for use in the United States as a diagnostic aid in determining the localization of and in the evaluation of non-lacunar stroke and complex partial seizures, as well as in the early diagnosis of Alzheimer's disease.^[1]^[2]

An analogue of amphetamine, iofetamine has shown to inhibit the reuptake of serotonin and norepinephrine as well as induce the release of these neurotransmitters and of dopamine with similar potencies to other amphetamines like d-amphetamine and p-chloroamphetamine.^[4]^[5] In addition, on account of its high lipophilicity, iofetamine rapidly penetrates the blood-brain-barrier.^[6] Accordingly, though not known to have been reported in the medical literature, iofetamine likely possesses psychostimulant and possibly entactogenic effects.^{[citation needed]} However, based on structure-activity relationships, it may also be highly neurotoxic to serotonergic and dopaminergic neurons similarly to most other para-halogenated amphetamines.^{[citation needed]}

References

^ ^a ^b Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 562. ISBN 978-3-88763-075-1. Retrieved 25 April 2012.
^ ^a ^b Druckenbrod RW, Williams CC, Gelfand MJ (January 1989). "Iofetamine hydrochloride I 123: a new radiopharmaceutical for cerebral perfusion imaging". DICP : the Annals of Pharmacotherapy 23 (1): 19–24. PMID 2655294.
^ Holman BL, Hill TC, Magistretti PL (1982). "Brain imaging with emission computed tomography and radiolabeled amines". Investigative Radiology 17 (3): 206–15. doi:10.1097/00004424-198201730-00002. PMID 6811496.
^ Winchell HS, Horst WD, Braun L, Oldendorf WH, Hattner R, Parker H (October 1980). "N-isopropyl-[123I] p-iodoamphetamine: single-pass brain uptake and washout; binding to brain synaptosomes; and localization in dog and monkey brain". Journal of Nuclear Medicine 21 (10): 947–52. PMID 6775056.
^ de Jong BM, Feenstra MG, Ruijter JM, van Royen EA (March 1989). "Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine". Experimental Neurology 103 (3): 297–9. doi:10.1016/0014-4886(89)90055-1. PMID 2920796.
^ Winchell HS, Baldwin RM, Lin TH (October 1980). "Development of I-123-labeled amines for brain studies: localization of I-123 iodophenylalkyl amines in rat brain". Journal of Nuclear Medicine 21 (10): 940–6. PMID 7420195.

English Journal

Pathophysiological decrease in the regional cerebral blood flow in Hashimoto's encephalopathy: a multiple-case SPECT study.

Muramatsu T1, Ikawa M, Yoneda M, Sugimoto K, Matsunaga A, Yamamura O, Hamano T, Okazawa H, Nakamoto Y.
European neurology.Eur Neurol.2014;72(1-2):13-9. doi: 10.1159/000358220. Epub 2014 Apr 25.
BACKGROUND: The aim of this study was to evaluate the changes in regional cerebral blood flow (rCBF) in multiple cases of Hashimoto's encephalopathy (HE).METHODS: Seven untreated patients with HE and 10 age-matched healthy controls underwent brain single photon emission computed tomography (SPECT) w
PMID 24777056

Dropped head syndrome preceding the onset of dementia with Lewy bodies.

Tanaka K1, Wada I, Okunomiya T, Shima A, Kambe D, Shinde A, Kageyama T, Suenaga T.
Internal medicine (Tokyo, Japan).Intern Med.2014;53(8):883-6. Epub 2014 Apr 15.
A 67-year-old woman developed dropped head. Her neck was severely flexed, with prominent cervical paraspinal muscles, although no parkinsonism was observed. Brain MRI showed no significant findings. We considered dystonia as the cause of the dropped head and administered trihexyphenidyl, an antichol
PMID 24739611

Surgical treatment for carotid stenoses with highly calcified plaques.

Katano H1, Mase M2, Nishikawa Y2, Yamada K2.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.J Stroke Cerebrovasc Dis.2014 Jan;23(1):148-54. doi: 10.1016/j.jstrokecerebrovasdis.2012.11.019. Epub 2012 Dec 25.
BACKGROUND: The aim of this study was to clarify both the present status of treatment for carotid stenosis with highly calcified plaques and the appropriate treatment.METHODS: A total of 140 consecutive treatments for carotid stenoses (carotid endarterectomy [CEA]:carotid artery stenting [CAS] 81:59
PMID 23273787

Japanese Journal

Correlation of functional independence measure (FIM) with SPECT Iofetamine (I-123) as a predictor of functional return in stroke

RUPRIGHT J.
Brain Injury 11, 49-57, 1997
NAID 30016499185

I-123 iofetamine SPECT scan in systemic lupus erythematosus patients with cognitive and other minor neuropsychiatric symptoms: a pilot study

ROGERS MP
Lupus 1, 215-219, 1992
NAID 30030769301

Iofetamine I 123 single photon emission computed tomography is accurate in the diagnosis of Alzheimer's disease

JOHNSON KA.
Arch Intern Med 150(4), 752-756, 1990
NAID 30005418582

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「イオフェタミン」

Iofetamine (¹²³I)
Systematic (IUPAC) name
	1-[4-(123I)iodophenyl]-N-isopropyl-2-propanamine
Clinical data
Legal status	℞ Prescription only;
Pharmacokinetic data
Protein binding	<10%
Identifiers
CAS number	75917-92-9; 85068-76-4 (non-labeled); 95896-48-3 (123I-labeled HCl)
ATC code	V09AB01
PubChem	CID 156375
ChemSpider	137706
ChEMBL	CHEMBL1201308
Chemical data
Formula	C12H18123IN
Mol. mass	299.278 g/mol
	SMILES CC(C)NC(C)Cc1ccc(cc1)I;
	InChI InChI=1S/C12H18IN/c1-9(2)14-10(3)8-11-4-6-12(13)7-5-11/h4-7,9-10,14H,8H2,1-3H3/i13-4; Key:ISEHJSHTIVKELA-DCWJVSPSSA-N ;

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英: iofetamine
関: N-イソプロピルパラヨードアンフェタミン、123I-塩酸N-イソプロピル-4-ヨードアンフェタミン

塩酸N-イソプロピル-4-ヨードアンフェタミン(123I)

[Index_Nominum_2000:_International_Drug_Directory-1] Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 562. ISBN 978-3-88763-075-1. Retrieved 25 April 2012.

[pmid2655294-2] Druckenbrod RW, Williams CC, Gelfand MJ (January 1989). "Iofetamine hydrochloride I 123: a new radiopharmaceutical for cerebral perfusion imaging". DICP : the Annals of Pharmacotherapy 23 (1): 19–24. PMID 2655294.

[pmid6811496-3] Holman BL, Hill TC, Magistretti PL (1982). "Brain imaging with emission computed tomography and radiolabeled amines". Investigative Radiology 17 (3): 206–15. doi:10.1097/00004424-198201730-00002. PMID 6811496.

[pmid6775056-4] Winchell HS, Horst WD, Braun L, Oldendorf WH, Hattner R, Parker H (October 1980). "N-isopropyl-[123I] p-iodoamphetamine: single-pass brain uptake and washout; binding to brain synaptosomes; and localization in dog and monkey brain". Journal of Nuclear Medicine 21 (10): 947–52. PMID 6775056.

[pmid2920796-5] Jong BM, Feenstra MG, Ruijter JM, van Royen EA (March 1989). "Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine". Experimental Neurology 103 (3): 297–9. doi:10.1016/0014-4886(89)90055-1. PMID 2920796.

[pmid7420195-6] Winchell HS, Baldwin RM, Lin TH (October 1980). "Development of I-123-labeled amines for brain studies: localization of I-123 iodophenylalkyl amines in rat brain". Journal of Nuclear Medicine 21 (10): 940–6. PMID 7420195.

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iofetamine