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English Journal

Intelligent Albumin-MnO2 Nanoparticles as pH-/H2 O2 -Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy.

Chen Q1, Feng L1, Liu J1, Zhu W1, Dong Z1, Wu Y1, Liu Z1.
Advanced materials (Deerfield Beach, Fla.).Adv Mater.2016 Jun 10. doi: 10.1002/adma.201601902. [Epub ahead of print]
A unique type of pH/H2 O2 dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO2 is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME-responsive size changes enable effective intratumor diffusion. A highly e
PMID 27283434

Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016).

Othman BA1, Greenwood C2, Abuelela AF3, Bharath AA4, Chen S1, Theodorou I1, Douglas T5, Uchida M5, Ryan M1, Merzaban JS3, Porter AE1,6.
Advanced healthcare materials.Adv Healthc Mater.2016 Jun;5(11):1248. doi: 10.1002/adhm.201670053.
On page 1310 J. S. Merzaban, A. E. Porter, and co-workers present fluorescently labeled RGD-targeted ZnO nanoparticles (NPs; green) for the targeted delivery of cytotoxic ZnO to integrin αvβ3 receptors expressed on triple negative breast cancer cells. Correlative light-electron microscopy shows th
PMID 27275627

Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity.

Othman BA1, Greenwood C2, Abuelela AF3, Bharath AA4, Chen S1, Theodorou I1, Douglas T5, Uchida M5, Ryan M1, Merzaban JS3, Porter AE1,6.
Advanced healthcare materials.Adv Healthc Mater.2016 Jun;5(11):1310-25. doi: 10.1002/adhm.201501012. Epub 2016 Apr 25.
ZnO nanoparticles (NPs) are reported to show a high degree of cancer cell selectivity with potential use in cancer imaging and therapy. Questions remain about the mode by which the ZnO NPs cause cell death, whether they exert an intra- or extracellular effect, and the resistance among different canc
PMID 27111660

Analysis of Intratumor Heterogeneity of EGFR Mutations in Mixed Type Lung Adenocarcinoma

Tomonaga Nanae,Nakamura Yoichi,Yamaguchi Hiroyuki,Ikeda Takaya,Mizoguchi Kosuke,Motoshima Kohei,Doi Seiji,Nakatomi Katsumi,Iida Tetsuya,Hayashi Tomayoshi,Nagayasu Takeshi,Tsukamoto Kazuhiro,Kohno Shigeru
Clinical Lung Cancer 14(5), 521-526, 2013-09
… Patients and Methods: The intratumor heterogeneity of EGFR mutations was analyzed in 38 patients with resected mixed-type lung adenocarcinoma according to histological patterns, and the clinical features of the patients harboring intratumor heterogeneity of EGFR mutations were evaluated. … Results: Intratumor heterogeneity of EGFR mutations was detected in 9 of 38 tumors. …
NAID 120005343839

Alteration of Tumor Microenvironment for Improved Delivery and Intratumor Distribution of Nanocarriers (Challenges of Drug Delivery Systems That Contribute to Cancer Chemotherapy)