WordNet

any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/21 12:55:01」(JST)

wiki en

Interleukin 9, also known as IL-9, is a cytokine (cell signalling molecule) belonging to the group of interleukins.^[1]

Function

The protein encoded by this gene is a cytokine produced by T-cells and specifically by CD4+ helper cells that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin-9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.^[1]

Interleukin-9 has also shown to inhibit melanoma growth in mice.^[2]

References

^ ^a ^b "Entrez Gene: IL9 interleukin 9".
^ Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS (July 2012). "Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells". Nat. Med. 18 (8): 1248–53. doi:10.1038/nm.2856. PMC 3518666. PMID 22772464. Lay summary – medicalxpress.com.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. リウマチ性疾患における生物学的製剤の概要 overview of biologic agents in the rheumatic diseases
2. 原発性免疫不全症に対する遺伝子治療 gene therapy for primary immunodeficiency
3. プロゲステロン受容体モジュレーター（PRM）の薬理学および作用機序 pharmacology and mechanism of action of progesterone receptor modulators prms
4. 適応細胞性免疫応答 the adaptive cellular immune response
5. JAK3欠損を伴う重度複合型免疫不全（SCID） severe combined immunodeficiency scid with jak3 deficiency

English Journal

Expression levels of transcription factor PU.1 and interleukin-9 in atopic dermatitis and their relation to disease severity and eruption types.

Hamza AM1, Omar SS1, Abo El-Wafa RA2, Elatrash MJ1.
International journal of dermatology.Int J Dermatol.2017 Feb 22. doi: 10.1111/ijd.13579. [Epub ahead of print]
PMID 28229452

Neutralization of interleukin-9 ameliorates symptoms of allergic rhinitis by reducing Th2, Th9, and Th17 responses and increasing the Treg response in a murine model.

Gu ZW1, Wang YX2, Cao ZW1.
Oncotarget.Oncotarget.2017 Feb 7. doi: 10.18632/oncotarget.15177. [Epub ahead of print]
PMID 28187441

Functional Significance of Interleukin-9 and Its Receptor System in the Pathogenesis of Psoriatic Arthritis: Comment on the Article by Ciccia et al.

Raychaudhuri SK1, Abria C1, Raychaudhuri SP2.
Arthritis & rheumatology (Hoboken, N.J.).Arthritis Rheumatol.2017 Feb;69(2):472-473. doi: 10.1002/art.39964.
PMID 27768837

Japanese Journal

House Dust Mite Extract Induces Interleukin-9 Expression in Human Eosinophils

Allergology international : official journal of the Japanese Society of Allergology 57(2), 141-146, 2008-06-01
NAID 10021246553

House Dust Mite Extract Induces Interleukin-9 Expression in Human Eosinophils

Allergology International 57(2), 141-146, 2008
NAID 130004476967

The Role of Interleukin-9 in Asthma

Allergology international : official journal of the Japanese Society of Allergology 54(1), 71-78, 2005-03-01
NAID 10014468709

Related Pictures

★リンクテーブル★

リンク元	「インターロイキン9」「IL-9」「インターロイキン-9」
拡張検索	「interleukin-9 receptor」
関連記事	「interleukin」「interleukins」

「インターロイキン9」

Interleukin 9
Identifiers
Symbols	IL9 ; HP40; IL-9; P40
External IDs	OMIM: 146931 MGI: 96563 HomoloGene: 492 GeneCards: IL9 Gene
Gene ontology
Molecular function	• cytokine activity; • interleukin-9 receptor binding; • growth factor activity;
Cellular component	• extracellular space;
Biological process	• inflammatory response; • immune response; • positive regulation of cell proliferation; • positive regulation of cell growth; • positive regulation of interleukin-5 biosynthetic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;