The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jan;1850(1):51-61. doi: 10.1016/j.bbagen.2014.10.001. Epub 2014 Oct 13.
BACKGROUND: The effect of in vivo treatment with ursolic acid (UA) on glycemia in hyperglycemic rats and its mechanism of action on muscle were studied.METHODS: The UA effects on glycemia, glycogen, LDH, calcium and on insulin levels were evaluated after glucose tolerance curve. The β-cells were ev
Combined Potentiating Action of Phytochemical(s) from Cinnamomum tamala and Aloe vera for their Anti-diabetic and Insulinomimetic Effect Using In Vivo Rat and In Vitro NIH/3T3 Cell Culture System.
Singh V1, Singh SP, Singh M, Gupta AK, Kumar A.
Applied biochemistry and biotechnology.Appl Biochem Biotechnol.2014 Dec 24. [Epub ahead of print]
The present investigation was undertaken to analyze the ethanolic extracts of leaves of Cinnamomum tamala and Aloe vera for their anti-diabetic and insulinomimitic effect by determining the levels of blood sugar, glycosylated hemoglobin, and serum lipid profile (total cholesterol, triglycerides, hig
European journal of medicinal chemistry.Eur J Med Chem.2014 Oct 30;86:491-501. doi: 10.1016/j.ejmech.2014.09.007. Epub 2014 Sep 6.
Glibenclamide is widely used in the management of non-insulin dependent diabetes mellitus, but numerous risks limit its use in therapy. In the search for novel structures that are safer and more efficient than glibenclamide, we obtained new chemical analogs based on bioisosterism, through the treatm
… Since the finding of insulinomimetic activity of Zn ion, several insulinomimetic Zn complexes have been reported. … Among the tropolonate-Zn complexes with various coordination environments, di(2-mercaptotropolonato)Zn with the Zn(S2O2) coordination environments was found to exhibit the highest in vitro insulinomimetic activity with respect to glucose uptake in isolated rat adipocytes treated with adrenaline. …
… (1) improvement of cardiovascular dysfunction in animals by di-nuclear Cu-asprinate complex on the basis of the results on its reactive oxygen scavenging (ROS) effect, (2) blood glucose-lowering effect of mono-nuclear Cu-picolinate complex in streptozotocin (STZ)-induced type 1-like diabetic animals, based on the results on in vitro insulinomimetic activity, and (3) anti-diabetic effect of copper sulfate in animals with regard to the inhibition of α-glucosidase activity. …
Chemical and Pharmaceutical Bulletin 59(8), 972-977, 2011
… The complexes with an electron-withdrawing group in the ligand exhibited higher in vitro insulinomimetic activity than those of Zn complexes with an electron-donating group in the ligand. …
The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells. J Biol Chem. 1990 Feb 15; 265(5):2896-902. [J Biol Chem. 1990] Combination of insulinomimetic agents H2O2 and vanadate ...
New Insulinomimetic Zinc(II) Complexes of a-Amino Acids and Their Derivatives with Zn(N 2 O 2) Coordination Mode Yutaka YOSHIKAWA,a Eriko UEDA,a Yuka SUZUKI,b Naohisa YANAGIHARA,b Hiromu SAKURAI,c and Yoshitane ...