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1. 糖尿病におけるインスリン療法の一般原則general principles of insulin therapy in diabetes mellitus [show details]
…for faster aspart and insulin aspart. Insulin lispro is identical to human regular insulin except for a lysine and proline at positions B28 and B29 respectively. Insulin glulisine has a lysine and glutamic …
2. 成人の1型糖尿病における血糖値マネージメントmanagement of blood glucose in adults with type 1 diabetes mellitus [show details]
… testing at home should be done at least four times daily, before meals and at bedtime. Additional testing,… Insulin degludec – Insulin degludec is a very long-acting basal insulin available in U-100 and U-200 formulations .…
3. 2型糖尿病におけるインスリン療法insulin therapy in type 2 diabetes mellitus [show details]
… person is testing his or her FBG at 7:00 or 8:00 AM, or bedtime or morning glargine or degludec. Since glargine and degludec can be administered any time of day, the timing of daily insulin glargine or degludec …
4. 糖尿病における吸入インスリン療法inhaled insulin therapy in diabetes mellitus [show details]
… lung disease and smoking) and need for periodic testing for safety. This topic reviews the efficacy, safety, and patient acceptability of inhaled insulin therapy. An overview of pharmacologic therapy for …
5. 小児や青年の1型糖尿病のマネージメントmanagement of type 1 diabetes mellitus in children and adolescents [show details]
… glucose test results, insulin administration, and the timing and carbohydrate content of meals and snacks. Blood glucose testing – Families must master blood glucose testing.… Long-acting insulin preparations (eg, insulin glargine, insulin detemir) are given once or twice a day. Insulin degludec has a longer duration of…

English Journal

Pheochromocytoma With Adrenergic Biochemical Phenotype Shows Decreased GLP-1 Secretion and Impaired Glucose Tolerance.

Petrák O, Klímová J, Mráz M, Haluzíková D, Doležalová RP, Kratochvílová H, Lacinová Z, Novák K, Michalský D, Waldauf P, Holaj R, Widimský J, Zelinka T, Haluzík M.
The Journal of clinical endocrinology and metabolism. 2020 Jun;105(6).
Impaired glucose homeostasis is a common finding in pheochromocytoma (PHEO), especially with adrenergic phenotype. The possible contribution of incretin dysfunction to dysglycemia in PHEO patients has not been studied. To compare changes in pancreatic endocrine function and gut hormones' production
PMID 32222768

Adipocyte Insulin Resistance In PCOS: Relationship With GLUT-4 Expression, Whole-Body Glucose Disposal, β-Cell Function.

Ezeh U, Chen IY, Chen YH, Azziz R.
The Journal of clinical endocrinology and metabolism. 2020 May;().
Impaired sensitivity to the antilipolytic action of insulin in adipose tissue (AT) may play a role in determining metabolic dysfunction in Polycystic Ovary Syndrome (PCOS). To test the hypothesis that insulin resistance (IR) in AT is associated with whole-body insulin sensitivity and β-cell functio
PMID 32382742

Decreased arterial distensibility and postmeal hyperinsulinemia in young Japanese women with family history of diabetes.

Takeuchi M, Wu B, Honda M, Tsuboi A, Kitaoka K, Minato S, Kurata M, Kazumi T, Fukuo K.
BMJ open diabetes research & care. 2020 May;8(1).
To assess vascular function and characterize insulin secretion using a physiological approach in Japanese women with family history of type 2 diabetes (FHD). Standardized mixed-meal tests were performed with multiple postprandial glucose, insulin and free fatty acids (FFA) measurements over a 30-120
PMID 32371532

Japanese Journal

Presence of aberrant adrenocorticotropic hormone precursors in two cases of McCune–Albright syndrome

Takayasu Shinobu,Makita Koshi,Kageyama Kazunori,Okawa Yuta,Oki Yutaka,Yamagata Satoshi,Asari Yuko,Terui Ken,Daimon Makoto
Endocrine Journal 67(3), 353-359, 2020
… Insulin tolerance and CRH tests showed hyper-responses of ACTH and an insufficient increase in cortisol levels. … Autonomous cortisol excess was excluded by the level of midnight cortisol and the level of cortisol after a low-dose dexamethasone suppression test in the two cases. …
NAID 130007821372

Impaired early-phase suppression of glucagon secretion after glucose load is associated with insulin requirement during pregnancy in gestational diabetes

Horie Ichiro,Haraguchi Ai,Ito Ayako,Nozaki Aya,Natsuda Shoko,Akazawa Satoru,Mori Yoshitaka,Ando Takao,Higashijima Ai,Hasegawa Yuri,Yoshida Atsushi,Miura Kiyonori,Masuzaki Hideaki,Kawakami Atsushi,Abiru Norio
Journal of Diabetes Investigation 11(1), 232-240, 2019-07-09
… The glucose intolerance in GDM is heterogeneous, and not all patients require insulin treatment during pregnancy. … Here, we investigated whether glucagon abnormality is associated with the requirement for insulin treatment during pregnancy. …
NAID 120006778556

Glucose-responsive Insulinoma with Insulin Hypersecretion Suppressed by Metformin

Hamano Kunihisa,Akita Kayo,Takeuchi Yoko,Suwa Tetsuya,Takeda Jun,Dodo Shuji
Internal Medicine 58(24), 3563-3568, 2019
… <p>In type 2 diabetes mellitus, metformin suppresses excessive insulin secretion in relation to the intake of glucose. … A 75-g oral glucose tolerance test after metformin administration revealed the suppression of glucose-responsive insulin hypersecretion and responsive hypoglycemia. …
NAID 130007761426