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Immunoadsorption is an alternative blood purification technique^[1] used to eliminate pathogenic antibodies^[2]^[3]^[4]

The technique shows results with rare side effects and a maximum elimination of pathogenic immunoglobulins from the blood.^[1]^[5]^[6]^[7]^[8]^[9]

References

^ ^a ^b Koziolek, Michael J; Tampe, Desiree; Bähr, Matthias; Dihazi, Hassan; Jung, Klaus; Fitzner, Dirk; Klingel, Reinhard; Müller, Gerhard A; Kitze, Bernd (2012). "Immunoadsorption therapy in patients with multiple sclerosis with steroid-refractory optical neuritis". Journal of Neuroinflammation 9: 80. doi:10.1186/1742-2094-9-80. PMC 3418188. PMID 22537481.
^ Ikeda, Uichi; Kasai, Hiroki; Izawa, Atsushi; Koyama, Jun; Yazaki, Yoshikazu; Takahashi, Masafumi; Higuchi, Makoto; Koh, Chang-Sung; Yamamoto, Keiji (2008). "Immunoadsorption Therapy for Patients with Dilated Cardiomyopathy and Heart Failure". Current Cardiology Reviews 4 (3): 219–22. doi:10.2174/157340308785160534. PMC 2780823. PMID 19936198.
^ Hohenstein, B.; Bornstein, S.R.; Aringer, M. (2013). "Immunoadsorption for connective tissue disease". Atherosclerosis Supplements 14 (1): 185–9. doi:10.1016/j.atherosclerosissup.2012.10.034. PMID 23357163.
^ Terman, Davids.; Buffaloe, George; Cook, Gary; Sullivan, Michael; Mattioli, Carlos; Tillquist, Richard; Carlos Ayus, Juan (1979). "Extracorporeal Immunoadsorption: Initial Experience in Human Systemic Lupus Erythematosus". The Lancet 314 (8147): 824. doi:10.1016/S0140-6736(79)92177-9.
^ Griveas, Ioannis; Visvardis, Georgios; Skoura, L; Iniotaki, A; Papadopoulou, D; Sakellariou, G (2010). "Immunoadsorption in Highly-Sensitized Kidney Transplant Recipients". Balkan Military Medical Review (Periodical of Balkan Military Medical Committee) 13 (2): 47–50.
^ "Highly efficient removal of antibodies in diseases with impaired immune response". Fresenius.
^ HW Jr Snyder; Cochran, SK; Balint Jr, JP; Bertram, JH; Mittelman, A; Guthrie Jr, TH; Jones, FR (1992-05-01). "Experience with protein A-immunoadsorption in treatment-resistant adult immune thrombocytopenic purpura". Blood 79 (9): 2237–45. PMID 1571540.
^ Schneider, KM (1998). "Plasmapheresis and immunoadsorption: Different techniques and their current role in medical therapy". Kidney international. Supplement 64: S61–5. PMID 9475492.
^ Schwenger, V.; Morath, C. (2010). "Immunoadsorption in nephrology and kidney transplantation". Nephrology Dialysis Transplantation 25 (8): 2407. doi:10.1093/ndt/gfq264.

External links

Immunoadsorption_Queen Elizabeth Hospital Birmingham

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1. 腎移植におけるHLAとABOの感作および脱感作 hla and abo sensitization and desensitization in renal transplantation
2. 抗GBM抗体（グッドパスチャー）病の治療 treatment of anti gbm antibody goodpastures disease
3. 難治性の尋常性天疱瘡および落葉状天疱瘡のマネージメント management of refractory pemphigus vulgaris and pemphigus foliaceus
4. 心不全に対する試験中および新規の治療 investigational and emerging therapies for heart failure
5. 心筋炎の病因および発症機序 etiology and pathogenesis of myocarditis

English Journal

Tailored Desensitisation Strategies in ABO Blood Group Antibody Incompatible Renal Transplantation.

Barnett AN, Manook M, Nagendran M, Kenchayikoppad S, Vaughan R, Dorling A, Hadjianastassiou VG, Mamode N.SourceRenal and Transplant Department, Guy's and St Thomas' NHS Foundation Trust; Division of Transplantation Immunology and Mucosal Biology, King's College London.
Transplant international : official journal of the European Society for Organ Transplantation.Transpl Int.2013 Nov 5. doi: 10.1111/tri.12234. [Epub ahead of print]
ABO blood group incompatible renal transplantation, using desensitisation procedures, is an effective strategy. Efforts have been made to reduce desensitisation: these are usually applied to all patients indiscriminately. The Guy's Hospital ABO blood group incompatible desensitisation regimen uses a
PMID 24188566

Multimodal Therapy of Recurrent Severe Acute Disseminated Encephalomyelitis: The Role of Immunoadsorption.

Beyersdorff A, Schlichting S, Stracke S, Langner S, Lauffer H, Heckmann M.SourceNeonatology/Pediatric Intensive Care, University of Greifswald, Germany.
Klinische Padiatrie.Klin Padiatr.2013 Oct 28. [Epub ahead of print]
PMID 24166090

Myasthenia Gravis: An Update for the Clinician.

Sieb JP.SourceDepartment of Neurology, HELIOS Hanseklinikum Stralsund, and University Hospital Bonn, Germany.
Clinical and experimental immunology.Clin Exp Immunol.2013 Oct 9. doi: 10.1111/cei.12217. [Epub ahead of print]
This article provides a thorough overview of the current advances in diagnosis and therapy of myasthenia gravis (MG). Nowadays the term 'myasthenia gravis' includes heterogeneous autoimmune diseases with a postsynaptic defect of neuromuscular transmission as the common feature. Myasthenia gravis sho
PMID 24117026

Japanese Journal

関節リウマチ・悪性関節リウマチに対するアフェレシス療法(<特集>血管炎症候群とアフェレシス)

日高利彦
日本アフェレシス学会雑誌 34(2), 131-136, 2015-05-31
… plasma exchange, double filtration plasmapheresis, cryofiltration plasmapheresis, immunoadsorption plasmapheresis, granulocytapheresis and leukocytapheresis (LCAP). …
NAID 110009964088

小児拡張型心筋症とアフェレシス(<特集>小児疾患とアフェレシス)

森口武史,松田兼一,針井則一,後藤順子,柳沢政彦,原田大希,菅原久徳,星合美奈子,小泉敬一
日本アフェレシス学会雑誌 34(1), 59-63, 2015-02-28
… Apheresis such as immunoadsorption (IA) or plasma exchange (PE) to remove such antibodies has been performed in adult DCM patients. …
NAID 110009922597

免疫吸着療法の併用により寛解導入し得た高齢発症ループス腎炎の1例

菅原翔,中澤純,富田一聖 [他],高谷季穂,藤野佳彦,山原康佑,磯野元秀
日本透析医学会雑誌 48(7), 443-448, 2015
症例は74歳, 男性. 糖尿病, 高血圧症, 脂質異常症で通院中に腎機能低下の進行, 蛋白尿, 血尿を認め紹介となった. 発熱と炎症反応, 血球減少から全身性エリテマトーデス (SLE) が疑われた. 次回外来の直前に著明な高K血症のため緊急入院となった. 腎障害に加え胸膜炎, 血液異常, 抗核抗体と抗ds-DNA抗体が陽性であり, 高齢発症のSLEと診断した. 持続的血液透析により高K血症の補正 …
NAID 130005090709