idiotope

• イディオタイプ抗原決定基、イディオトープ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/24 22:34:24」(JST)

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An idiotope is the unique set of antigenic determinants (epitopes) of the variable portion of an antibody. In some cases it can be the actual antigen-binding site, and in some cases it may comprise variable region sequences outside of the antigen-binding site on the antibody itself. Thus each antibody would have multiple idiotopes; and the set of these individual idiotopes is termed the idiotype of the antibody.

Idiotopes contrast with allotopes, which are non-varying structures on the Fc receptor.

If a separate antibody is produced that has specific binding capabilities to an idiotope of the previously described antibody, it is said to be an "anti-idiotypic antibody". If such is the case, the anti-idiotypic antibodies will be able to bind to the B lymphocyte receptor for the original antigen and inhibit the immune response to that antigen.

This type of regulation was proposed by Niels Jerne in 1974. He termed it the "Network Hypothesis". This type of B lymphocyte regulation may be partially responsible for preventing an immune response from getting out of control, which would elicit damage to host tissue or even cause an autoimmune diseased state.

Because of the resemblance of anti-idiotypic antibodies to the original antigen, vaccine studies have been performed. These types of vaccines are called "idiotypic vaccines". None are produced commercially to date.

References

English Journal

• Antigenic specificity and expression of a natural idiotope on human pentameric and hexameric IgM polymers.

• Petrušić V, Zivković I, Stojanović M, Stojićević I, Marinković E, Inić-Kanada A, Dimitijević L.SourceDepartment of Research and Development, Institute of Virology, Vaccines and Sera-Torlak, Vojvode Stepe 458, 11221 Belgrade, Serbia. vzpetrusic@gmail.com
• Immunologic research.Immunol Res.2011 Oct;51(1):97-107. doi: 10.1007/s12026-011-8236-8.
• Natural antibodies (NAbs) are present in circulation even before the exposure to antigen and they exert various biological functions. They are polyreactive and mainly represented by immunoglobulin M (IgM), which is the first antibody produced in an ongoing immune response to infection and/or immuniz
• PMID 21786026

• Immunoregulatory role for a public IgM idiotype in the induction of autoimmune diseases in Mycoplasma pneumoniae infection.

• Ben Aissa-Fennira F, Sassi A, Bouguerra A, Benammar-Elgaaied A.SourceLaboratoire d'Hématologie, Faculté de Médecine de Tunis, Université Tunis El Manar, Tunis, Tunisia. f.benaissa.fennira@gmail.com
• Immunology letters.Immunol Lett.2011 May;136(2):130-7. doi: 10.1016/j.imlet.2010.11.006. Epub 2010 Dec 4.
• Mycoplasma pneumoniae (MP) infection is associated with the emergence of various autoimmune disorders and autoantibody production. The most common autoantibodies induced are of anti-I specificity and express cold agglutinin (CA) activity. However, the mechanisms by which the microbial infection trig
• PMID 21134402

Japanese Journal

• 免疫システムによる行動選択法の提案と移動ロボットの障害物回避問題への応用

• 永見 広次,小林 祐介,坂野 進
• 日本機械学會論文集. C編 65(634), 2386-2391, 1999-06-25
• … We propose a new approach to behavior based AI using the biological immune mechanisms, We introduce the idiotope network which has been proposed by N. …
• NAID 110002384231

• 特徴抽出への抗体-抗抗体相互作用モデルの応用

• 菊池 保文,下岡 聡行,清水 孝一
• 電子情報通信学会技術研究報告. PRMU, パターン認識・メディア理解 98(528), 165-172, 1999-01-22
• 我々は、液性免疫系のモデルとしてイディオタイプネットワークをとりあげ、パターン認識への応用を試みている。認識対象を抗原と考えると、液性免疫系は抗体というテンプレートを用いてパターンマッチングを行っていると考えられる。ネットワーク説では、抗原は、抗体間の相互作用による動的変化を経て、内部イメージに置き換えられるとされる。このことから、抗体の濃度変化が入力されたパターンの本質的な特徴を表現し得るのでは …
• NAID 110003274877

• Resting small B cells present endogenous immunoglobulin variable-region determinants to idiotope-specific CD4^+ T cells in vivo

• MUNTHE L. A.
• Eur. J. Immunol. 29, 4043, 1999
• NAID 10011230574

Related Links

• idiotope - definition of idiotope by Medical dictionary

idiotope [id′ē·ətōp′] an antigenic determinant on a variable region of an immunoglobulin molecule. idiotope an antigenic determinant on the variable region of an antibody. id·i·o·tope (id'ē-ō-tōp), Single antigenic determinant of an idiotype. ...

• idiotope - Definition - Mondofacto

idiotope definition from the mondofacto online medical dictionary ... Bookmark with: word visualiser Go and visit our forums

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イディオタイプ決定基 idiotypic determinant

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