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abnormally inactive (同)underactive

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/12 21:14:31」(JST)

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Hypoactivity is an inhibition of behavioral or locomotor activity.

Hypoactivity is a characteristic effect of sedative agents and many centrally acting anesthetics. Other drugs such as antipsychotics and mCPP also produce this effect, often as a side effect.

References

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English Journal

Methylphenidate for gait hypokinesia and freezing in patients with Parkinson's disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial.

Moreau C, Delval A, Defebvre L, Dujardin K, Duhamel A, Petyt G, Vuillaume I, Corvol JC, Brefel-Courbon C, Ory-Magne F, Guehl D, Eusebio A, Fraix V, Saulnier PJ, Lagha-Boukbiza O, Durif F, Faighel M, Giordana C, Drapier S, Maltête D, Tranchant C, Houeto JL, Debû B, Sablonniere B, Azulay JP, Tison F, Rascol O, Vidailhet M, Destée A, Bloem BR, Bordet R, Devos D; for the Parkgait-II study group.SourceDepartment of Movement Disorders and Neurology, Lille Nord de France University, CHU Lille, Lille, France; EA 4559, Alzheimer's Disease and Vascular Pathologies, Lille Nord de France University, CHU Lille, Lille, France.
Lancet neurology.Lancet Neurol.2012 Jul;11(7):589-596. Epub 2012 Jun 1.
BACKGROUND: Despite optimum medical management, many patients with Parkinson's disease are incapacitated by gait disorders including freezing of gait. We aimed to assess whether methylphenidate-through its combined action on dopamine and noradrenaline reuptake-would improve gait disorders and freezi
PMID 22658702

Hypoactivity of the central dopaminergic system and autistic-like behavior induced by a single early prenatal exposure to lipopolysaccharide.

Kirsten TB, Chaves-Kirsten GP, Chaible LM, Silva AC, Martins DO, Britto LR, Dagli ML, Torrão AS, Palermo-Neto J, Bernardi MM.SourceDepartment of Pathology, School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil. thik@hotmail.com.
Journal of neuroscience research.J Neurosci Res.2012 Jun 20. doi: 10.1002/jnr.23089. [Epub ahead of print]
The aim of the present study was to evaluate the behavioral patterns associated with autism and the prevalence of these behaviors in males and females, to verify whether our model of lipopolysaccharide (LPS) administration represents an experimental model of autism. For this, we prenatally exposed W
PMID 22714803

Japanese Journal

Resveratrol Improves Hippocampal Atrophy in Chronic Fatigue Mice by Enhancing Neurogenesis and Inhibiting Apoptosis of Granular Cells

Moriya Junji,Chen Rui,Yamakawa Jun-ichi [他],Sasaki Kenroh,Ishigaki Yasuhito,Takahashi Takashi
Biological and Pharmaceutical Bulletin 34(3), 354-359, 2011
… abortus antigen could induce hypoactivity and hippocampal atrophy in mice. …
NAID 130000657812

Improved synthesis and in vitro/in vivo activities of natural product-inspired, artificial glutamate analogs

Oikawa Masato,Ikoma Minoru,Sasaki Makoto,Gill Martin B.,Swanson Geoffrey T.,Shimamoto Keiko,Sakai Ryuichi
Bioorganic & Medicinal Chemistry 18(11), 3795-3804, 2010-06-01
… Conversely, intracranial injection of 7c into mice produced a greater degree of hypoactivity than 1a. …
NAID 120002169301

Home-cage activity, Open-field, Passive avoidanceテストで得られた正常コントロールデータに基づくENU優性行動変異体のスクリーニング

和田由美子,古瀬民生,山田郁子 [他],MASUYA Hiroshi,KUSHIDA Tomoko,SHIBUKAWA Yoko,NAKAI Yuji,KOBAYASHI Kimio,KANEDA Hideki,GONDO Yoichi,NODA Tetsuo,SHIROISHI Toshihiko,WAKANA Shigeharu
Experimental Animals 59(4), 495-510, 2010
… In the G2 mice, we identified 15 novel dominant mutants exhibiting behavioral abnormalities, including hyperactivity in the HA or OF tests, hypoactivity in the OF test, and PA deficits. …
NAID 130000298610