ヒト血小板抗原

WordNet

sing with closed lips; "She hummed a melody"
a humming noise; "the hum of distant traffic" (同)humming
be noisy with activity; "This office is buzzing with activity" (同)buzz, seethe
sound with a monotonous hum (同)thrum
make a low continuous sound; "The refrigerator is humming"
relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects"
characteristic of humanity; "human nature"
having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty"
any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
tiny bits of protoplasm found in vertebrate blood; essential for blood clotting (同)blood_platelet, thrombocyte

PrepTutorEJDIC

〈ハチ・機械などが〉『ブンブンいう』,ブーンと鳴る / 『鼻歌を歌う』,ハミングスル / (ちゅうちょ・当惑で)ふむふむいう / 《話》〈雰囲気・事業などが〉活気がある,活発に動く;(…で)活気づく《+『with』+『名』》 / …‘を'『ハミングで歌う』,鼻歌を歌って…‘を'(ある状熊に)する / (ハチ・機械などの)『ブンブン』[『うなる音』];鼻歌 / (雑踏などの)ガヤガヤ]いう音],騒音 / ふ‐む,う‐ん(ちゅうちょ・当惑・黙考・疑惑・不快などの声)
(動物・神に対して)『人間の』,人の / 『人間らいし』,人間的な,人情味のある / 〈C〉《複数形》(動物に怠して)人間(human being) / 〈U〉《the human》人類
抗原(生物の体内にはいって免疫体を作る物質)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/22 02:35:27」(JST)

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Human platelet antigens (HPA) are polymorphisms in platelet antigens. These can stimulate production of alloantibodies, (antibodies against other people's antigens) in recipients of transfused platelets from donors with different HPAs. These antibodies cause neonatal alloimmune thrombocytopenia, post-transfusion purpura and some cases of platelet transfusion refractoriness to infusion of donor platelets.^[1]

Overview

A nomenclature was devised by International Society of Blood Transfusion (ISBT), platelet working party to overcome problems generated by many different nomenclatures in use. Since inception of this list, a greater number of antigens have been described and the molecular basis of many has been resolved.

To date, 24 platelet-specific alloantigens have been defined by immune sera, of which 12 are grouped in six biallelic systems (HPA-1, -2, -3, -4, -5, -15). For the remaining 12, alloantibodies against the thetical but not the antithetical antigen have been observed. The molecular basis of 22 of the 24 serologically defined antigens has been resolved. In all but one of the 22, the difference between self and non-self is defined by a single amino acid substitution generally caused by a single-nucleotide polymorphism (SNP).

System	Antigen	Original names	Glycoprotein	CD
HPA-1	HPA-1a	1aZw	GPIIIa	CD61
	HPA-1b	Zwb	GPIIIa	CD

References

^ Metcalfe P, Watkins N, Ouwehand W, Kaplan C, Newman P, Kekomaki R, De Haas M, Aster R, Shibata Y, Smith J, Kiefel V, Santoso S (2003). "Nomenclature of human platelet antigens". Vox Sang. 85 (3): 240–5. doi:10.1046/j.1423-0410.2003.00331.x. PMID 14516468.

External links

http://www.ebi.ac.uk/ipd/hpa/
Human Platelet Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)

This immunology article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 血小板輸血療法に対する不応性 refractoriness to platelet transfusion therapy
2. 血小板輸血療法の臨床上および検査上の特徴 clinical and laboratory aspects of platelet transfusion therapy
3. Neonatal alloimmune thrombocytopenia: Parental evaluation and pregnancy management
4. 先天性および後天性血小板機能障害 congenital and acquired disorders of platelet function
5. Clinical manifestations, evaluation, and management of neonatal thrombocytopenia

English Journal

Development of a novel flow cytometric immunobead array to quantify VWF:Ag and VWF:GPIbR and its application in acute myocardial infarction.

Yan B1,2, Xu M1,2, Zhao Y1,2, Guo H3, Xia L1,2,4, Ruan C1,2, Zhao Y1,2.
European journal of haematology.Eur J Haematol.2017 May 18. doi: 10.1111/ejh.12905. [Epub ahead of print]
PMID 28523822

Analysis of platelet-reactive alloantibodies and evaluation of cross-match-compatible platelets for the management of patients with transfusion refractoriness.

Wang J1, Xia W1, Deng J1, Xu X1, Shao Y1, Ding H1, Chen Y1, Liu J1, Chen D1, Ye X1, Santoso S1,2.
Transfusion medicine (Oxford, England).Transfus Med.2017 May 18. doi: 10.1111/tme.12423. [Epub ahead of print]
PMID 28516675

Platelet concentrates modulate myeloid dendritic cell immune responses.

Ki KK1,2, Faddy HM1,2, Flower RL1, Dean MM1.
Platelets.Platelets.2017 May 15:1-10. doi: 10.1080/09537104.2017.1306045. [Epub ahead of print]
PMID 28503991