human immunodeficiency virus ribonuclease H

ヒト免疫不全症ウイルスリボヌクレアーゼH

WordNet

1. sing with closed lips; "She hummed a melody"
2. a humming noise; "the hum of distant traffic" (同)humming
3. be noisy with activity; "This office is buzzing with activity" (同)buzz, seethe
4. sound with a monotonous hum (同)thrum
5. make a low continuous sound; "The refrigerator is humming"
6. relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects"
7. characteristic of humanity; "human nature"
8. having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty"
9. a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
10. (virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
11. a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
12. the 8th letter of the Roman alphabet (同)h
13. immunological disorder in which some part of the bodys immune system is inadequate and resistance to infectious diseases is reduced

PrepTutorEJDIC

1. 〈ハチ・機械などが〉『ブンブンいう』,ブーンと鳴る / 『鼻歌を歌う』,ハミングスル / (ちゅうちょ・当惑で)ふむふむいう / 《話》〈雰囲気・事業などが〉活気がある,活発に動く;(…で)活気づく《+『with』+『名』》 / …‘を'『ハミングで歌う』,鼻歌を歌って…‘を'(ある状熊に)する / (ハチ・機械などの)『ブンブン』[『うなる音』];鼻歌 / (雑踏などの)ガヤガヤ]いう音],騒音 / ふ‐む,う‐ん(ちゅうちょ・当惑・黙考・疑惑・不快などの声)
2. (動物・神に対して)『人間の』,人の / 『人間らいし』,人間的な,人情味のある / 〈C〉《複数形》(動物に怠して)人間(human being) / 〈U〉《the human》人類
3. ビールス,ろ過性病原体
4. hydrogenの化学記号
5. 鉛筆の硬度 / 《俗》heroin

UpToDate Contents

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• 1. HIV感染患者における日和見感染症の一次予防の概要 overview of primary prevention of opportunistic infections in hiv infected patients
• 2. 中枢神経系病変を有するHIV感染患者に対するアプローチ approach to hiv infected patients with central nervous system lesions
• 3. 青年および成人におけるHIV感染の自然経過および臨床的特徴 the natural history and clinical features of hiv infection in adults and adolescents
• 4. HIV感染およびAIDSの神経精神学的側面の概要 overview of the neuropsychiatric aspects of hiv infection and aids
• 5. 輸血によるHIV感染およびAIDS transfusion transmitted hiv infection and aids

English Journal

• N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase.

• Pescatori L1, Métifiot M2, Chung S3, Masoaka T3, Cuzzucoli Crucitti G1, Messore A1, Pupo G1, Madia VN1, Saccoliti F1, Scipione L1, Tortorella S1, Di Leva FS4, Cosconati S5, Marinelli L4, Novellino E4, Le Grice SF3, Pommier Y2, Marchand C2, Costi R1, Di Santo R1.
• Journal of medicinal chemistry.J Med Chem.2015 Jun 11;58(11):4610-23. doi: 10.1021/acs.jmedchem.5b00159. Epub 2015 May 26.
• Bifunctional quinolinonyl DKA derivatives were first described as nonselective inhibitors of 3'-processing (3'-P) and strand transfer (ST) functions of HIV-1 integrase (IN), while 7-aminosubstituted quinolinonyl derivatives were proven IN strand transfer inhibitors (INSTIs) that also displayed activ
• PMID 25961960

• Structural integrity of the ribonuclease H domain in HIV-1 reverse transcriptase.

• Slack RL1, Spiriti J2, Ahn J1, Parniak MA3, Zuckerman DM2, Ishima R1.
• Proteins.Proteins.2015 Jun 9. doi: 10.1002/prot.24843. [Epub ahead of print]
• The mature form of reverse transcriptase (RT) is a heterodimer comprising the intact 66-kDa subunit (p66) and a smaller 51-kDa subunit (p51) that is generated by removal of most of the RNase H (RNH) domain from a p66 subunit by proteolytic cleavage between residues 440/441. Viral infectivity is elim
• PMID 26061827

• The hepatitis B virus ribonuclease H as a drug target.

• Tavis JE1, Lomonosova E2.
• Antiviral research.Antiviral Res.2015 Jun;118:132-138. doi: 10.1016/j.antiviral.2015.04.002. Epub 2015 Apr 8.
• Chronic hepatitis B virus (HBV) infection is a leading cause of hepatitis, liver failure, and hepatocellular carcinoma. An outstanding vaccine is available; however, the number of infections remains high. Current anti-HBV treatments with interferon α and nucleos(t)ide analogs clear the infection in
• PMID 25862291

Japanese Journal

• Structural Modulation Study of Inhibitory Compounds for Ribonuclease H Activity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

• Chemical and Pharmaceutical Bulletin 60(6), 764-771, 2012
• NAID 130001852478

• 好酸球の役割に関する考察

• 炎症・再生 22(2), 105-113, 2002
• NAID 130003708763

• Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Ribonuclease H Activites by Constituents of Juglans mandshurica

• Chemical & pharmaceutical bulletin 48(2), 194-200, 2000-02-01
• NAID 110003635427

Related Links

• HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and ...

Since the human immunodeficiency virus (HIV) was discovered as the etiological agent of acquired immunodeficiency syndrome (AIDS), it has encouraged much research into antiviral compounds. The reverse ...

• The hepatitis B virus ribonuclease H is sensitive to inhibitors ...

1. PLoS Pathog. 2013 Jan;9(1):e1003125. doi: 10.1371/journal.ppat.1003125. Epub 2013 Jan 22. The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and ...

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★リンクテーブル★

リンク元	「ヒト免疫不全症ウイルスリボヌクレアーゼH」
関連記事	「human」「ribonuclease H」「H」「immunodeficiency」「virus」

「ヒト免疫不全症ウイルスリボヌクレアーゼH」

　　[★]

英

human immunodeficiency virus ribonuclease H

「human」

　　[★]

• n.

• ヒト

• adj.

• ヒトの、ヒト型の

関

ape、hominid、Hominidae、homo、Homo sapiens、human being、human race、human-type、man、Pongidae

　 　 　 　

「ribonuclease H」

　　[★]

リボヌクレアーゼH

関

calf thymus ribonuclease H、RNase H

「H」

　　[★]

• 食道裂孔
• ヒスチジン
• 水素

　 　 　

「immunodeficiency」

　　[★] 免疫不全症 → 免疫不全症候群 　

「virus」

　　[★] ウイルス