WordNet

antibacterial substance that is a water-soluble powder used in antiseptic soaps and toothpaste

English Journal

Detection of pH Change in Cytoplasm of Live Myocardial Ischemia Cells via the ssDNA-SWCNTs Nanoprobes.

Liu R1, Liu L, Liang J, Wang Y, Wei Y, Gao F, Gao L, Gao X.Author information 1CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences , Beijing 100049, China.AbstractMyocardial ischemia is featured by a significant increase in the cytoplasm proton concentration, and such a proton change may be applied as an index for earlier ischemic heart disease diagnostics. But such a pH change in a live heart cell is difficult to monitor as a normal fluorescent probe cannot specifically transport into the cytoplasm of an ischemic cell. This is because the heart cell contains condensed myofibrils which are tight barriers for a normal probe to penetrate. We design fluorescent probes, single-strand DNA wrapped single-wall carbon nanotubes (ssDNA-SWCNTs), where the ssDNA is labeled by the dye molecule hexachloro-6-carboxyfluorescein (HEX). This nanoprobe could transport well into a live heart cell and locate in the cytoplasm to sensitively detect the intracellular pH change of myocardial ischemia. Briefly, protons neutralize the negative charges of nanoprobes in the cytoplasm. This will weaken the stability of nanoprobes and further tune their aggregation. Such aggregations induce the HEX of some nanoprobes condensed together and further result in their fluorescence quenching. The nanoprobes are advantaged in penetrating condensed myofibrils of the heart cell, and their fluorescence intensity is sensitive to the proton concentration change in the live cell cytoplasm. This new method may provide great assistance in earlier cardiopathy diagnosis in the future.
Analytical chemistry.Anal Chem.2014 Mar 18;86(6):3048-52. doi: 10.1021/ac500499q. Epub 2014 Mar 5.
Myocardial ischemia is featured by a significant increase in the cytoplasm proton concentration, and such a proton change may be applied as an index for earlier ischemic heart disease diagnostics. But such a pH change in a live heart cell is difficult to monitor as a normal fluorescent probe cannot
PMID 24568645

Temperature-Dependent Raman Spectroscopic Evidence of and Molecular Mechanism for Irreversible Isomerization of β-Endosulfan to α-Endosulfan.

Schmidt WF1, Hapeman CJ, McConnell LL, Mookherji S, Rice CP, Nguyen JK, Qin J, Lee H, Chao K, Kim MS.Author information 1Agricultural Research Service, United States Department of Agriculture , 10300 Baltimore Avenue, Beltsville, Maryland 20705-2325, United States.AbstractEndosulfan (6,7,8, 9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine-3-oxide) is a broad-spectrum, organochlorine insecticide used on numerous crops since the 1950s. It is has been identified as a persistent organic pollutant (POP) due to its persistence, bioaccumulation, long-range transport, and adverse effects to human health and aquatic ecosystems; it will be phased out in the United States in 2016. Endosulfan consists of two diastereomers, α and β; α-endosulfan exists as two asymmetrical, twist-chair enantiomers which interchange, while β-endosulfan has a symmetrical-chair conformation. β-Endosulfan has been shown to isomerize to α-endosulfan. Here we document the previously proposed isomerization mechanism using temperature-dependent Raman (TDR) spectroscopy. The bending frequencies in the fingerprint region were assigned to specific bonds. Changes in the signal intensity as a function of temperature were used to identify detailed ring movements and thus conversion of β to α. These movements cannot occur simultaneously nor symmetrically, precluding conversion of α-endosulfan to β-endosulfan.
Journal of agricultural and food chemistry.J Agric Food Chem.2014 Mar 5;62(9):2023-30. doi: 10.1021/jf404404w. Epub 2014 Feb 21.
Endosulfan (6,7,8, 9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine-3-oxide) is a broad-spectrum, organochlorine insecticide used on numerous crops since the 1950s. It is has been identified as a persistent organic pollutant (POP) due to its persistence, bioaccumulatio
PMID 24491184

Plasma concentrations of persistent organic pollutants in the Cree of northern Quebec, Canada: results from the multi-community environment-and-health study.

Liberda EN1, Tsuji LJ2, Martin ID2, Cote S3, Ayotte P4, Dewailly E5, Nieboer E6.Author information 1School of Occupational and Public Health, Ryerson University, Toronto, ON, Canada. Electronic address: eric.liberda@ryerson.ca.2Department of Environment and Resource Studies, University of Waterloo, Waterloo, ON, Canada.3Santé publique et pratiques optimales en santé, Centre de Recherche du CHU de Québec, Québec, QC, Canada.4Santé publique et pratiques optimales en santé, Centre de Recherche du CHU de Québec, Québec, QC, Canada; Laboratoire de toxicologie, INSPQ, 945, Avenue Wolfe, Québec, QC, Canada.5Laboratoire de toxicologie, INSPQ, 945, Avenue Wolfe, Québec, QC, Canada.6Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.AbstractHistorically, resource development has had negative impacts on the traditional lifestyle of First Nation Cree Communities in the Province of Quebec, Canada. In response to the perceived need for fisheries restoration and for managing health concerns associated with environmental pollutants, the Mercury Program in the James Bay Region of Quebec was reconstituted in 2001 and broadened to include a wider range of chemicals of concern. Based on comprehensive surveys of the nine Cree Territory (Eeyou Istchee) communities in this region during the period 2002-2009, blood plasma concentrations are presented of Aroclor 1260, PCB congeners 28, 52, 99, 101, 105, 118, 128, 138, 153, 156, 163, 170, 180, 183, and 187, Aldrin, ß-HCH, α-Chlordane, γ-Chlordane, oxy-Chlordane, trans-Nonachlor, cis-Nonachlor, p,p'-DDT, p,p'-DDE, Hexachloro benzene (HCB), Mirex, PBB 153, PBDE 47, PBDE 99, PBDE 100, PBDE 153, Toxaphene 26, and Toxaphene 50. The organohalogenated compounds were extracted using solid-phase extraction and cleaned on florisil columns before high resolution HRGC-MS analysis. Principal component analysis (PCA) was used to reduce the large number of contaminant variables into a smaller number of uncorrelated variables. ANOVA identified significant differences between age groups, with the older participants having higher body burdens of legacy lipophilic contaminants, but not for the PBDEs. In certain female age groups, plasma concentrations of PBDEs were observed to be lower than for males; conversely, DDT was higher. Among communities, concentrations were different (p<0.001) for all contaminants. This work provides a baseline for the James Bay Eeyou Istchee communities who, to varying degrees, rely on food and other resources from the land and therefore are at higher risk of increased body burdens of legacy persistent organic pollutants (POPs).
The Science of the total environment.Sci Total Environ.2014 Feb 1;470-471:818-28. doi: 10.1016/j.scitotenv.2013.10.048. Epub 2013 Nov 2.
Historically, resource development has had negative impacts on the traditional lifestyle of First Nation Cree Communities in the Province of Quebec, Canada. In response to the perceived need for fisheries restoration and for managing health concerns associated with environmental pollutants, the Merc
PMID 24189104

Japanese Journal

Differential uptake and translocation of β-HCH and dieldrin by several plant species from hydroponic medium

Environmental toxicology and chemistry 34(3), 536-544, 2015-03
NAID 120005606344

Chloride Complexation of Zr and Hf in HCl Investigated by Extended X-ray Absorption Fine Structure Spectroscopy: Toward Characterization of Chloride Complexation of Element 104, Rutherfordium (Rf)