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Genetic background of uric acid metabolism in a patient with severe chronic tophaceous gout.

Petru L1, Pavelcova K1, Sebesta I2, Stiburkova B3.
Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2016 Sep 1;460:46-9. doi: 10.1016/j.cca.2016.06.007. Epub 2016 Jun 9.
Hyperuricemia depends on the balance of endogenous production and renal excretion of uric acid. Transporters for urate are located in the proximal tubule where uric acid is secreted and extensively reabsorbed: secretion is principally ensured by the highly variable ABCG2 gene. Enzyme hypoxanthine-gu
PMID 27288985

Product Release Pathways in Human and Plasmodium falciparum Phosphoribosyltransferase.

Karmakar T1, Roy S1, Balaram H1, Prakash MK1, Balasubramanian S1.
Journal of chemical information and modeling.J Chem Inf Model.2016 Aug 22;56(8):1528-38. doi: 10.1021/acs.jcim.6b00203. Epub 2016 Jul 21.
Atomistic molecular dynamics (MD) simulations coupled with the metadynamics technique were carried out to delineate the product (PPi.2Mg and IMP) release mechanisms from the active site of both human (Hs) and Plasmodium falciparum (Pf) hypoxanthine-guanine-(xanthine) phosphoribosyltransferase (HG(X)
PMID 27404508

Henssen AG1, Jiang E1, Zhuang J2, Pinello L3, Socci ND4, Koche R5, Gonen M6, Villasante CM1, Armstrong SA5,7, Bauer DE3, Weng Z2, Kentsis A8,9,10.
BMC genomics.BMC Genomics.2016 Aug 4;17:548. doi: 10.1186/s12864-016-2877-x.
BACKGROUND: Numerous human genes encode potentially active DNA transposases or recombinases, but our understanding of their functions remains limited due to shortage of methods to profile their activities on endogenous genomic substrates.RESULTS: To enable functional analysis of human transposase-de
PMID 27491780

Radiation-quality Dependent Cellular Response in Mutation Induction in Normal Human Cells

Suzuki Masao,Tsuruoka Chizuru,Uchihori Yukio [他],KITAMURA Hisashi,LIU Cui Hua
Journal of radiation research 50(5), 395-399, 2009-09-16
… In mutation induction, which was detected in the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus to measure 6-thioguanine resistant clones, there was no difference in mutation frequency induced by the X-ray challenging dose between unpretreated and gamma-ray pretreated cells. …
NAID 10025912493

In Vivo Mutagenesis Caused by Diesel Exhaust in the Testis of gpt delta Transgenic Mice

Hashimoto Akiko H.,Amanuma Kimiko,Masumura Kenichi [他],Nohmi Takehiko,Aoki Yasunobu
Genes and environment : the official journal of the Japanese Environmental Mutagen Society 31(1), 1-8, 2009-02-20
… gpt delta Transgenic mice carrying the guanine phosphoribosyltransferase (gpt) transgene for the detection of mutations in genomic DNA were exposed to inhalation of 3mg m^<-3> …
NAID 110007138019

リンク元	「グアニンホスホリボシルトランスフェラーゼ」
拡張検索	「hypoxanthine-guanine phosphoribosyltransferase」
関連記事	「phosphoribosyltransferase」