グリセロール-3-リン酸-O-アシルトランスフェラーゼ
WordNet
- the 15th letter of the Roman alphabet (同)o
- the blood group whose red cells carry neither the A nor B antigens; "people with type O blood are universal donors" (同)type_O, group O
- a salt of phosphoric acid (同)orthophosphate, inorganic_phosphate
- carbonated drink with fruit syrup and a little phosphoric acid
- a sweet syrupy trihydroxy alcohol obtained by saponification of fats and oils (同)glycerin, glycerine
PrepTutorEJDIC
- 《呼び掛けの名前の前につけて》『おお』,あ / (驚き・恐れ・喜び・苦痛などを表して)『おお』,ああ,まあ / 《肯定・否定を強めて》
- oxygenの化学記号
- ohmオーム / Old
- 〈U〉リン酸塩 / 《複数形で》リン酸肥料
- osmiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/13 10:02:31」(JST)
[Wiki en表示]
| glycerol-3-phosphate O-acyltransferase |
| Identifiers |
| EC number |
2.3.1.15 |
| CAS number |
9029-96-3 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a glycerol-3-phosphate O-acyltransferase (EC 2.3.1.15) is an enzyme that catalyzes the chemical reaction
- acyl-CoA + sn-glycerol 3-phosphate CoA + 1-acyl-sn-glycerol 3-phosphate
Thus, the two substrates of this enzyme are acyl-CoA and sn-glycerol 3-phosphate, whereas its two products are CoA and 1-acyl-sn-glycerol 3-phosphate.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase. Other names in common use include alpha-glycerophosphate acyltransferase, 3-glycerophosphate acyltransferase, ACP:sn-glycerol-3-phosphate acyltransferase, glycerol 3-phosphate acyltransferase, glycerol phosphate acyltransferase, glycerol phosphate transacylase, glycerophosphate acyltransferase, glycerophosphate transacylase, sn-glycerol 3-phosphate acyltransferase, and sn-glycerol-3-phosphate acyltransferase. This enzyme participates in glycerolipid metabolism and glycerophospholipid metabolism.
Structural studies [edit]
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1IUQ and 1K30.
References [edit]
- Bertrams M and Heinz E (1981). "Positional Specificity and Fatty Acid Selectivity of Purified sn-Glycerol 3-Phosphate Acyltransferases from Chloroplasts". Plant Physiol. 68 (3): 653–657. doi:10.1104/pp.68.3.653. PMC 425956. PMID 16661974.
- Frentzen M, Heinz E, McKeon TA, Stumpf PK (1983). "Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts". Eur. J. Biochem. 129 (3): 629–36. doi:10.1111/j.1432-1033.1983.tb07096.x. PMID 6825679.
- Green PR, Vanaman TC, Modrich P, Bell RM (1983). "Partial NH2- and COOH-terminal sequence and cyanogen bromide peptide analysis of Escherichia coli sn-glycerol-3-phosphate acyltransferase". J. Biol. Chem. 258 (18): 10862–6. PMID 6350296.
- Yamashita S, Numa S (1972). "Partial purification and properties of glycerophosphate acyltransferase from rat liver. Formation of 1-acylglycerol 3-phosphate from sn-glycerol 3-phosphate and palmityl coenzyme A". Eur. J. Biochem. 31 (3): 565–73. doi:10.1111/j.1432-1033.1972.tb02566.x. PMID 4650158.
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Transferases: acyltransferases (EC 2.3)
|
|
| 2.3.1: other than amino-acyl groups |
- acetyltransferases: Acetyl-Coenzyme A acetyltransferase
- N-Acetylglutamate synthase
- Choline acetyltransferase
- Dihydrolipoyl transacetylase
- Acetyl-CoA C-acyltransferase
- Beta-galactoside transacetylase
- Chloramphenicol acetyltransferase
- N-acetyltransferase
- Serotonin N-acetyl transferase
- HGSNAT
- ARD1A
- Histone acetyltransferase
- palmitoyltransferases: Carnitine O-palmitoyltransferase
- Serine C-palmitoyltransferase
- other: Acyltransferase like 2
- Aminolevulinic acid synthase
- Beta-ketoacyl-ACP synthase
- Glyceronephosphate O-acyltransferase
- Lecithin-cholesterol acyltransferase
- Glycerol-3-phosphate O-acyltransferase
- 1-acylglycerol-3-phosphate O-acyltransferase
- 2-acylglycerol-3-phosphate O-acyltransferase
- ABHD5
|
|
| 2.3.2: Aminoacyltransferases |
- Gamma-glutamyl transpeptidase
- Peptidyl transferase
- Transglutaminase
- Tissue transglutaminase
- Keratinocyte transglutaminase
- Factor XIII
|
|
| 2.3.3: converted into alkyl on transfer |
- Citrate synthase
- ATP citrate lyase
- HMG-CoA synthase
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 2.7.10
- 2.7.11-12
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- Characterization of mitochondrial glycerol-3-phosphate acyltransferase in notothenioid fishes.
- Keenan KA1, Grove TJ2, Oldham CA1, O'Brien KM3.
- Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.Comp Biochem Physiol B Biochem Mol Biol.2017 Feb;204:9-26. doi: 10.1016/j.cbpb.2016.11.001. Epub 2016 Nov 9.
- Hearts of Antarctic icefishes (suborder Notothenioidei, family Channichthyidae) have higher densities of mitochondria, and mitochondria have higher densities of phospholipids, compared to red-blooded notothenioids. Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the rate-limiting step in glyce
- PMID 27836743
- Four Acyltransferases Uniquely Contribute to Phospholipid Heterogeneity in Saccharomyces cerevisiae.
- Oelkers P1, Pokhrel K2.
- Lipid insights.Lipid Insights.2016 Nov 28;9:31-41. eCollection 2016.
- Diverse acyl-CoA species and acyltransferase isoenzymes are components of a complex system that synthesizes glycerophospholipids and triacylglycerols. Saccharomyces cerevisiae has four main acyl-CoA species, two main glycerol-3-phosphate 1-O-acyltransferases (Gat1p, Gat2p), and two main 1-acylglycer
- PMID 27920551
- Protective Effect of Gomisin N against Endoplasmic Reticulum Stress-Induced Hepatic Steatosis.
- Jang MK1, Yun YR, Kim SH, Kim JH, Jung MH.
- Biological & pharmaceutical bulletin.Biol Pharm Bull.2016 May 1;39(5):832-8. doi: 10.1248/bpb.b15-01020. Epub 2016 Feb 9.
- Gomisin N is a physiological substance derived from Schisandra chinensis. In the present study, the in vitro and in vivo effects of gomisin N on endoplasmic reticulum (ER) stress and hepatic steatosis were investigated. We quantified the expression of markers of ER stress, including glucose regulate
- PMID 26860972
Related Links
- Weber, S.; Wolter, F.P.; Buck, F.; Frentzen, M.: Purification and cDNA sequencing of an oleate-selective acyl-ACP: sn-glycerol-3-phosphate acyltransferase from pea chloroplasts. Plant Mol. Biol., 17, 1067–1076 (1991) CrossRef ...
- References for "Glycerol-3-phosphate O-acyltransferase" im Internet, an Universitäten und in der Literatur... cyclopaedia.net ... In enzymology, a glycerol-3-phosphate O-acyltransferase (EC 2.3.1.15) is an enzyme that catalyzes the chemical reaction
★リンクテーブル★
[★]
- 英
- glycerol-3-phosphate O-acyltransferase
[★]
1-アシルグリセロール-3-リン酸-O-アシルトランスフェラーゼ
[★]
- 関
- inorganic phosphate、orthophosphate、orthophosphoric acid、phospho、phosphoester、phosphoric、phosphoric acid、phosphoric acid ester、phosphorus
[★]
アシルトランスフェラーゼ、アシル転移酵素、アシル基転移酵素
- 関
- transacylase
[★]
グリセロール、グリセリン
[★]
- 同
- 食道入口部
[★]
オスミウム osmium