グルタル酸(ペンタン-1,5-ジカルボン酸, pentane-1,5-dicarboxylic acid)は５つの炭素原子を持つジカルボン酸である。

HOOC-CH₂-CH₂-C_H2-COOH

3分子のacetyl-CoAが重合してHMG-CoAができるが、グルタル酸はその骨格をなす？

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1. 有機酸血症 organic acidemias
2. グルコース-6-ホスファターゼ欠損症（糖原病I型、フォンギールケ病） glucose 6 phosphatase deficiency glycogen storage disease i von gierke disease
3. 炎症性腸疾患の小児および青年における重要な健康維持の問題 important health maintenance issues for children and adolescents with inflammatory bowel disease
4. 乳児、小児、および思春期における炎症性腸疾患の臨床的症状および診断 clinical presentation and diagnosis of inflammatory bowel disease in infants children and adolescents

English Journal

Acute renal proximal tubule alterations during induced metabolic crises in a mouse model of glutaric aciduria type 1.

Thies B, Meyer-Schwesinger C, Lamp J, Schweizer M, Koeller DM, Ullrich K, Braulke T, Mühlhausen C.SourceChildren´s Hospital, Department of Biochemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Apr 23. pii: S0925-4439(13)00143-9. doi: 10.1016/j.bbadis.2013.04.019. [Epub ahead of print]
The metabolic disorder glutaric aciduria type 1 (GA1) is caused by deficiency of the mitochondrial glutaryl-CoA dehydrogenase (GCDH), leading to accumulation of pathologic metabolites glutaric acid (GA) and 3-hydroxyglutaric acid (3OHGA) in blood, urine and tissues. Affected patients are prone to me
PMID 23623985

Structure of a class III engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity.

Golden E, Paterson R, Tie WJ, Anandan A, Flematti G, Molla G, Rosini E, Pollegioni L, Vrielink A.Source*School of Chemistry and Biochemistry, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.
The Biochemical journal.Biochem J.2013 Apr 15;451(2):217-26. doi: 10.1042/BJ20121715.
The crystal structure of the wild-type form of glutaryl-7-ACA (7-aminocephalosporanic acid) acylase from Pseudomonas N176 and a double mutant of the protein (H57βS/H70βS) that displays enhanced catalytic efficiency on cephalosporin C over glutaryl-7-aminocephalosporanic acid has been determined. T
PMID 23373797

Aggarwal RK, Showkathali R.SourceBasildon University Hospital, Essex Cardiothoracic Centre , Basildon , UK +44 08451553111, ext 4326 ; +44 01268394334 ; Rajesh.Aggarwal@btuh.nhs.uk.
Expert opinion on pharmacotherapy.Expert Opin Pharmacother.2013 Apr 11. [Epub ahead of print]
Introduction: Low-density lipoprotein cholesterol (LDL-C) reduction using 3-hydroxy-3-methyl glutaryl coenzyme A (HMGCoA) reductase inhibitors (statins) has a proven survival benefit in patients presenting with acute coronary syndromes (ACS). Patients presenting with ACS remain at significant risk o
PMID 23574635

Paeoniflorin Protects against Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice

Involvement of Hepatic IL-1 in the Strain-Dependent Sex Differences in Serum Total Cholesterol Levels in Rats

リンク元

name=グルタル酸
構造式=
IUPAC=1,5-ペンタン二酸
ペンタン-1,5-ジカルボン酸
別名=プロパン-1,3-ジカルボン酸
1,3-プロパンジカルボン酸
n-ピロ酒石酸
分子式=C₅H₈O₄
分子量=132.12
CAS登録番号=110-94-1
融点=95～98
沸点=200

グルタル酸(Glutaric acid)は示性式HOOC(CH₂)₃COOHで表されるカルボン酸の一つ。IUPAC命名法では1,5-ペンタン二酸(1,5-pentanedioic acid)またはペンタン-1,5-ジカルボン酸(pentane-1,5-dicarboxylic acid)である。無色からわずかに薄い黄色の結晶または結晶性粉末で、水に可溶、アルコール、エーテル (化学)に易溶。融点95～98℃、沸点302℃、分子量132.11。CAS登録番号は110-94-1。