WordNet
- any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
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- 酵素
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/10 06:04:09」(JST)
[Wiki en表示]
| Endothelin-converting enzyme 1 |
| Identifiers |
| EC number |
3.4.24.71 |
| CAS number |
138238-81-0 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
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Endothelin-converting enzyme 1 (EC 3.4.24.71, endothelin-converting enzyme, ECE-1) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of the -Trp21-Val- bond in big endothelin to form endothelin 1
This metalloendopeptidase belongs to the peptidase family M13.
References[edit]
- ^ Takahashi, M., Matsushita, Y., Iijima, Y. and Tanzawa, K. (1993). "Purification and characterization of endothelin-converting enzyme from rat lung". J. Biol. Chem. 268: 21394–21398. PMID 8407980.
- ^ Shimada, K., Takahashi, M. and Tanzawa, K. (1994). "Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells". J. Biol. Chem. 269: 18275–18278. PMID 8034569.
- ^ Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., DeWit, D. and Yanagisawa, M. (1994). "ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1". Cell 78: 473–485. PMID 8062389.
External links[edit]
- Endothelin-converting enzyme 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca(2+) in adult cardiac myocytes.
- Merlen C, Farhat N, Luo X, Chatenet D, Tadevosyan A, Villeneuve LR, Gillis MA, Nattel S, Thorin E, Fournier A, Allen BG.SourceMontreal Heart Institute, Montréal, Quebec H1T 1C8, Canada; Department of Biochemistry, Montréal, Quebec H3C 3J7, Canada.
- Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2013 Sep;62:189-202. doi: 10.1016/j.yjmcc.2013.05.021. Epub 2013 Jun 10.
- Endothelin receptors are present on the nuclear membranes in adult cardiac ventricular myocytes. The objectives of the present study were to determine 1) which endothelin receptor subtype is in cardiac nuclear membranes, 2) if the receptor and ligand traffic from the cell surface to the nucleus, and
- PMID 23756157
- Role of Oxidative Stress Induced Endothelin Converting Enzyme Activity in the Alteration of Carotid Body Function by Chronic Intermittent Hypoxia.
- Peng YJ, Nanduri J, Raghuraman G, Wang N, Kumar GK, Prabhakar NR.SourceUniversity of Chicago, United States.
- Experimental physiology.Exp Physiol.2013 Aug 30. [Epub ahead of print]
- Chronic intermittent hypoxia (CIH) leads to remodeling of the carotid body function manifested by augmented sensory response to hypoxia and induction of sensory long-term facilitation (LTF). It was proposed that endothelin-1 (ET-1) contributes to CIH-induced hypoxic hypersensitivity of the carotid b
- PMID 23913764
Japanese Journal
- Physiological Relevance of Hydrolysis of Atrial Natriuretic Peptide by Endothelin-Converting Enzyme-1
- PE-189 Endothelin Converting Enzyme-1 Inhibition Augments Arteriogenesis in Streptozotocin Induced Type 1 Diabetic Hindlimb Ischemia Model(PE032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Circulation journal : official journal of the Japanese Circulation Society 73(Supplement_I), 446, 2009-03-01
- NAID 110007510974
- Total synthesis of an endothellin converting enzyme inhibitor, TMC-66
Related Links
- Endothelin Converting Enzyme-1 (ECE-1) plays a significant role in the regulation of vascular tone and hence blood pressure. It has also been implicated in the ... In addition to the production of endothelin and thus its role in regulating ...
- 1. Rev Port Cardiol. 2008 Mar;27(3):385-408. Endothelin-converting enzyme inhibitors: their application in cardiovascular diseases. [Article in English, Portuguese] Cerdeira AS(1), Brás-Silva C, Leite-Moreira AF. Author ...
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- endothelin-converting enzyme