Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes.
Atorvastatin, fluvastatin and rosuvastatin are drugs used for treatment of hypercholesterolemia. They cause numerous drug-drug interactions by inhibiting and inducing drug-metabolizing cytochromes P450. These three statins exist in four optical forms, but they are currently used as enantiopure drugs
Tri-O-acetyl-D-allal has been enantiospecifically synthesized in six steps from levoglucosenone in 55% overall yield. A key step in the synthesis is the anhydro bridge ring-opening with concomitant formation of a 1,3-oxathiolane-2-thione ring.
PURPOSE: Many abusers of dl-methylphenidate co-abuse ethanol. The present animal study examined behavioral effects of oral or transdermal DL-methylphenidate in combination with a high, depressive dose of ethanol to model co-abuse.METHODS: Locomotor activity of C57BL/6J mice was recorded for 3 h foll
Journal of fermentation and bioengineering 74(3), 189-190, 1992-09-25
… In this system, D-proline in the racemate is enantiospecifically oxidized to form Δ^1-pyrroline-2-carboxylic acid, which is immediately reduced to DL-proline. …
Synthesis of Kifunensine, an Immunomodulating Substrate Isolated from a Microbial Source
茅切 浩,笠原 千義,中村 克哉,奥 照夫,橋本 眞志
Chemical & pharmaceutical bulletin 39(6), 1392-1396, 1991-06-25
… Kifunensine (1), a novel immunomodulat isolated from an actinomycete, was enantiospecifically synthesized from D-mannosamine via a double cyclization of the oxamide-aldehyde precursor with ammonia as a key stop. …
Synthesis of Kifunensine, an Immunomodulating Substance Isolated from a Microbial Source.
茅切 浩,笠原 千義,中村 克哉,奥 照夫,橋本 眞志
Chemical and Pharmaceutical Bulletin 39(6), 1392-1396, 1991
… Kifunensine (1), a novel immunomodulat isolated from an actinomycete, was enantiospecifically synthesized from D-mannosamine via a double cyclization of the oxamide-aldehyde precursor with ammonia as a key stop. …
2015 September 15, “Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes” [1], PLOS ONE, DOI: 10 ...
Abstract Hydroxynitrile lyases are versatile enzymes that enantiospecifically cope with cyanohydrins, important intermediates in the production of various agrochemicals or pharmaceuticals. We determined four atomic ...