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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/24 21:24:24」(JST)

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Dromotropic derives from the Greek word "dromos", meaning running, a course, a race. A dromotropic agent is one which affects the conduction speed in the AV node, and subsequently the rate of electrical impulses in the heart.^[1]^[2]

Agents that are dromotropic are often (but not always) inotropic and chronotropic. For example, parasympathetic stimulation is usually negatively dromotropic, inotropic, and chronotropic.

Non-dihydropyridine calcium channel blockers such as verapamil block the slow inward calcium current in cardiac tissues, thereby having a negatively dromotropic, chronotropic and inotropic effect.^[3] This (and other) pharmacological effect makes these drugs useful in the treatment of angina pectoris. Conversely, they can lead to symptomatic disturbances in cardiac conduction and bradyarrhythmias, and may aggravate left ventricular failure.^[4]

References

^ Furukawa, Y.; Wallick, D. W.; Martin, P. J.; Levy, M. N. (1 May 1990). "Chronotropic and dromotropic responses to stimulation of intracardiac sympathetic nerves to sinoatrial or atrioventricular nodal region in anesthetized dogs". Circulation Research 66 (5): 1391–1399. doi:10.1161/01.RES.66.5.1391. PMID 2335032.
^ Dromotropic at eMedicine Dictionary
^ eTG complete
^ AccessMedicine - Harrison's Internal Medicine: Stable Angina Pectoris^{[dead link]}

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English Journal

Slow pathway ablation for typical atrioventricular nodal re-entrant tachycardia significantly alters the autonomic modulation of atrioventricular conduction.

Havranek S, Souckova L, Simek J, Wichterle D.Source2nd Department of Medicine - Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, U Nemocnice 2, Prague, 128 08, Czech Republic, stepan.havranek@lf1.cuni.cz.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society.Clin Auton Res.2013 Dec;23(6):289-95. doi: 10.1007/s10286-013-0207-9. Epub 2013 Jul 24.
PURPOSE: Atrioventricular (AV) conduction turbulence, biphasic dromotropic response of AV node to single ventricular premature contraction (VPC), consists of early shortening and later prolongation of AV conduction intervals due to the direct electrophysiological mechanisms and perturbation in auton
PMID 23880968

Chronotropic and dromotropic responses to localized glutamate microinjections in the rat nucleus ambiguus.

Sampaio KN, Mauad H, Michael Spyer K, Ford TW.SourceDivision of Biosciences, Faculty of Life Sciences, University College London, Gower Street, London WC1E 6BT, UK.
Brain research.Brain Res.2013 Oct 24. pii: S0006-8993(13)01426-1. doi: 10.1016/j.brainres.2013.10.035. [Epub ahead of print]
The cardioinhibitory effects of cardiac vagal motoneurons (CVMs) are mediated by activation of postganglionic neurons in the epicardial ganglia which have been shown to exert functionally selective effects on heart rate and atrioventricular conduction in the rat. Here we investigate whether CVMs pro
PMID 24177045

Combination of veno-arterial extracorporeal membrane oxygenation and hypothermia for out-of-hospital cardiac arrest due to Taxus intoxication.

Thooft A, Goubella A, Fagnoul D, Taccone FS, Brimioulle S, Vincent JL, De Backer D.AbstractABSTRACTA young woman presented with cardiac arrest following ingestion of yew tree leaves of the Taxus baccata species. The toxin in yew tree leaves has negative inotropic and dromotropic effects. The patient had a cardiac rhythm that alternated between pulseless electrical activity with a prolonged QRS interval and ventricular fibrillation. When standard resuscitation therapy including digoxin immune Fab was ineffective, a combination of extracorporeal membrane oxygenation (ECMO) and hypothermia was initiated. The total duration of low flow/no flow was 82 minutes prior to the initiation of ECMO. After 36 hours of ECMO (including 12 hours of electrical asystole), the patient's electrocardiogram had normalized and the left ventricular ejection fraction was 50%. At this time, dobutamine and the ECMO were stopped. The patient had a full neurologic recovery and was discharged from the intensive care unit after 5 days and from the hospital 1 week later.
CJEM.CJEM.2013;15(0):1-4.
ABSTRACTA young woman presented with cardiac arrest following ingestion of yew tree leaves of the Taxus baccata species. The toxin in yew tree leaves has negative inotropic and dromotropic effects. The patient had a cardiac rhythm that alternated between pulseless electrical activity with a prolonge
PMID 24192344

Japanese Journal

Electropharmacological Effects of Oseltamivir Assessed in the Halothane-Anesthetized in vivo Canine Model

Kitahara Ken,Nakamura Yuji,Yamazaki Junichi,Adachi-Akahane Satomi,Sugiyama Atsushi
Journal of Arrhythmia 27(Supplement), PE4_069-PE4_069, 2011
… The middle dose prolonged ventricular repolarization period at a pacing cycle length of 300 ms, which was not observed at 400 ms. The high dose prolonged ventricular repolarization period at 300 ms, the extent of which was comparable to that induced at 400 ms. Thus, oseltamivir showed the negative chronotropic, inotropic, dromotropic and hypotensive effects in addition to the repolarization delay. …
NAID 130002129717

学生定期健康診断の心電図でみられた呼吸性右脚ブロック

丸山徹,永野純,眞崎義憲 [他],入江正洋,上園慶子,Maruyama Toru,Nagano Jun,Masaki Yoshinori,Irie Masahiro,Uezono Keiko,マルヤマトオル,ナガノジュン,マサキヨシノリ,イリエマサヒロ,ウエゾノケイコ
健康科学 31, 99-103, 2009-00-00
… Respiratory RBBB is considered to be attributable mainly to cyclic right ventricular expansion in addition to rate-dependent functional block of right bundle branch synchronized by inspiration (first three cases) or negative dromotropic actions based on juvenile vagotony without macroscopic heart rate variability (fourth case). …
NAID 120001177104

Extracellular Potassium Dependent Negative Dromotropic Action of Nicorandil in Guinea Pig Myocardium

Kuma Fumiaki,Maruyama Toru,Ito Hiroyuki,Kaji Yoshikazu,Harada Mine,久間文明,丸山徹,伊東裕幸,加治良一,原田実根,クマフミアキ,マルヤマトオル,イトウヒロユキ,カジヨシカズ,ハラダミネ
福岡医学雑誌 95(4), 98-107, 2004-04-25
… Although the antiarrhythmic action of nicorandil is drawing an increasing attention, dromotropic effect of this agent is unclear. … Negative dromotropic action of nicorandil was slight but significant (p < …
NAID 120002834496