English Journal

The antiretroviral drug pipeline: prospects and implications for future treatment research.

Flexner C, Saag M.SourceaJohns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, Maryland bUniversity of Alabama at Birmingham, Birmingham, Alabama, USA.
Current opinion in HIV and AIDS.Curr Opin HIV AIDS.2013 Nov;8(6):572-578.
PURPOSE OF REVIEW: A number of investigational antiretroviral drugs in clinical development could alter the future treatment landscape for resource-limited settings and contribute to optimized therapy for HIV infection.RECENT FINDINGS: Several nucleoside reverse transcriptase inhibitors (NRTIs) are
PMID 24100879

Modeling the cost-effectiveness of HIV treatment: how to buy the most 'health' when resources are limited.

Kessler J, Braithwaite RS.SourceDivision of Comparative Effectiveness and Decision Science, Department of Population Health, New York University School of Medicine, New York, New York, USA.
Current opinion in HIV and AIDS.Curr Opin HIV AIDS.2013 Nov;8(6):544-549.
PURPOSE OF REVIEW: To summarize recent cost-effectiveness analyses (CEAs) that evaluate optimal treatment strategies for persons living with HIV/AIDS (PLWHA).RECENT FINDINGS: Efforts to attain universal coverage of current treatment guidelines (e.g., initiation at CD4 cell count <350 cells/μl)
PMID 24100874

Severe toxicity and polymerase-γ gene abnormalities in Malawian adults on stavudine-based antiretroviral therapy.

van Oosterhout JJ, Gardner K, Mallewa J, Kaunda S, Kampira E, Payne B, Heyderman RS, Chinnery P.SourceaMalawi-Liverpool Wellcome Trust Clinical Research Programme Departments of bMedicine cPathology, College of Medicine, Blantyre dDignitas International, Zomba, Malawi eInstitute of Genetic Medicine, Newcastle University, Newcastle, UK fDivision of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Pharmacogenetics and genomics.Pharmacogenet Genomics.2013 Nov;23(11):624-626.
In a cohort study of Malawian adults who were followed up through their second year of stavudine-containing antiretroviral therapy, we sequenced the polymerase-γ gene (POLG) of 10 of the 14 patients with the most severe stavudine side effects. No mutations were observed, suggesting that monogenic P
PMID 23962909

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