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Deslanoside (trade name Cedilanide in Brazil^[1]) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). It is found in the leaves of Digitalis lanata, the Woolly Foxglove.^[2]^[3]

References

^ Drugs.com: Cedilanide
^ Bakke, O. M.; Aslaksen, A.; Lehmann, V.; Lien, E. (1981). "Pharmacokinetics and serum concentration--effect relationship of intravenous deslanoside". Journal of cardiovascular pharmacology 3 (5): 1015–1025. doi:10.1097/00005344-198109000-00012. PMID 6168847. edit
^ Budavari, Susan, ed. (1996), The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (12th ed.), Merck, ISBN 0911910123 , 2967

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

English Journal

A sensitive method for digoxin determination using formate-adduct ion based on the effect of ionization enhancement in liquid chromatograph-mass spectrometer.

Li X1, Wang Y1, Zhou Q1, Yu Y2, Chen L3, Zheng J3.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2015 Jan 26;978-979:138-44. doi: 10.1016/j.jchromb.2014.11.023. Epub 2014 Dec 11.
A sensitive and rapid method based on formate-adduct ion detection was developed and fully validated for digoxin determination in rat plasma. For LC/MS/MS detection with formate-adducts as precursor ions, transitions of m/z 825.5→779.9 for digoxin and m/z 809.5→763.4 for the internal standard (d
PMID 25544010

Characteristics of deslanoside-induced modulation on jejunal contractility.

Chen DP1, Xiong YJ, Tang ZY, Yao QY, Ye DM, Liu SS, Lin Y.
World journal of gastroenterology.World J Gastroenterol.2012 Nov 7;18(41):5889-96. doi: 10.3748/wjg.v18.i41.5889.
AIM: To characterize the dual effects of deslanoside on the contractility of jejunal smooth muscle.METHODS: Eight pairs of different low and high contractile states of isolated jejunal smooth muscle fragment (JSMF) were established. Contractile amplitude of JSMF in different low and high contractile
PMID 23139604

Effects of acute administration of ethanol on experimental arrhythmia.

Gao Y1, Li P, Ma LX, Du KX, Wang XH, Tang MJ, He HK, Yu XJ, Zang WJ, Hu H.
The Chinese journal of physiology.Chin J Physiol.2012 Oct 31;55(5):307-13. doi: 10.4077/CJP.2012.BAA053.
Many studies have shown that the relationship between alcohol consumption and most cardiovascular diseases is U-shaped, with nondrinkers and heavier drinkers having higher risks than moderate drinkers. However, the association between cardiac arrhythmias and acute alcohol consumption is not well un
PMID 23282204

Japanese Journal

心アミロイドーシスを有する患者の上腹部緊急手術の麻酔管理

桜井康良,岡田智志穂
日本臨床麻酔学会誌 19(10), 626-629, 1999
要旨うっ血性心不全を呈する心アミロイドーシス患者の上腹部緊急手術の麻酔を経験した.症例は62歳の男性で,主訴は上腹部痛であった.全身に著明な浮腫があり,心エコーではアミロイドの沈着による心筋輝度の上昇が認められ,拡張不全型の心不全と診断された.フロセミド投与,デスラノシドの急速飽和の後,入眠量のチオペンタールとケタミンで導入し,酸素-亜酸化窒素-ケタミン-フェンタニルで麻酔を維持した.手術室で抜 …
NAID 130003428292

研究大動脈弁閉鎖不全に対する強心薬の効果:ジギタリスとカテコールアミンの対比

中村節,鼠尾祥三,沢山俊民,河原洋介,長谷川浩一,井上省三,田中淳二,田村敬二
心臓 26(5), 479-486, 1994
… 大動脈弁閉鎖不全(AR)に対する強心薬の効果についての報告はまれであり,一定心拍数下で検討した報告はみられない.今回,一定心拍数下でDeslanoside(DES)とDobutamine(DOB)の心血行動態に及ぼす影響を検討した.雑種成犬19頭を用いて,麻酔開胸後,バスケット型カテーテルにて重症AR(平均逆流率:67.5%)を作成した.洞結節破壊後,右房ペーシングにて心拍数を毎分120に固定した.10頭にDES 25μg/kgを経静脈的に投与,9頭にDOB2～12μg/kg/minを経 …
NAID 130004413191

症例 Sick sinus syndrome(SSS)を呈した筋強直性ジストロフィー症の1例

中野知子,清水光行,小川和彦,溝上恒男,入交修,八木寿夫,磯貝行秀
心臓 26(1), 75-78, 1994
… 上室性頻拍症と診断したが停止できず,緊急入院となった.入院時,180～190/minの頻拍を認め,verapamil,deslanosideの投与により心拍数90～100/min,2:1～3:1の心房粗動となった.発作前の体表面心電図では,心拍数53/minの洞性リズムであった.電気生理学的検査にて,HV時間の延長,洞機能不全と診断された.Permanent pacemakerを植え込んだ上で,頻拍性不整脈の治療を行った.その後,外来で経過観察中に,房室ブロックが進行した.心臓の刺激伝導障 …
NAID 130004413097

「デスラノシド」

Deslanoside
Systematic (IUPAC) name
	(3β,5β,12β)-3-[(O-β-D-glucopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	17598-65-1
ATC code	C01AA07
PubChem	CID 28620
DrugBank	DB01078
ChemSpider	26618
UNII	YGY317RK75
KEGG	D01240
ChEBI	CHEBI:31468
ChEMBL	CHEMBL1614
Chemical data
Formula	C47H74O19
Molecular mass	943.08 g/mol
	InChI InChI=1S/C47H74O19/c1-20-41(64-36-16-30(50)42(21(2)60-36)65-37-17-31(51)43(22(3)61-37)66-44-40(56)39(55)38(54)32(18-48)63-44)29(49)15-35(59-20)62-25-8-10-45(4)24(13-25)6-7-27-28(45)14-33(52)46(5)26(9-11-47(27,46)57)23-12-34(53)58-19-23/h12,20-22,24-33,35-44,48-52,54-57H,6-11,13-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27-,28+,29+,30+,31+,32-,33-,35+,36+,37+,38-,39+,40-,41-,42-,43-,44+,45+,46+,47+/m1/s1 ; Key:OBATZBGFDSVCJD-LALPQLPRSA-N ;
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　　[★]

英: deslanoside
ラ: deslanosidum
同: デアセチルラナトシドC deacetyllanatoside C、デスアセチルジギラニドC desacetyldigilanide C
商: ジギラノゲン、デスラノシン
関: ジギトキシン、ラナトシドC

[1] Drugs.com: Cedilanide

[2] Bakke, O. M.; Aslaksen, A.; Lehmann, V.; Lien, E. (1981). "Pharmacokinetics and serum concentration--effect relationship of intravenous deslanoside". Journal of cardiovascular pharmacology 3 (5): 1015–1025. doi:10.1097/00005344-198109000-00012. PMID 6168847. edit

[3] Budavari, Susan, ed. (1996), The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (12th ed.), Merck, ISBN 0911910123 , 2967

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deslanoside