clotiapine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/11 18:18:41」(JST)

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Clotiapine

Systematic (IUPAC) name
8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine
Clinical data
Trade names	Etumina, Etumine, Entumin, Etomine, Entumine
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only)
Routes of administration	Oral, Intravenous and Intramuscular
Identifiers
CAS Number	2058-52-8 N
ATC code	N05AH06
PubChem	CID: 16351
ChemSpider	15510 Y
UNII	Z05HCY0X1T Y
KEGG	D01597 Y
ChEMBL	CHEMBL304902 Y
Chemical data
Formula	C18H18ClN3S
Molecular mass	343.87 g/mol
SMILES Clc2ccc1Sc4c(/N=C(\c1c2)N3CCN(C)CC3)cccc4
InChI InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3 Y Key:KAAZGXDPUNNEFN-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Clotiapine (Entumine) is an atypical antipsychotic of the dibenzothiazepine chemical class. It was first introduced in a few European countries (namely, Belgium, Italy, Spain and Switzerland), Argentina, Taiwan and Israel in 1970.

Some sources regard clotiapine as a typical antipsychotic rather than atypical due to its high incidence of extrapyramidal side effects compared to the atypicals like clozapine and quetiapine, to which it is structurally related. Despite its profile of a relatively high incidence of extrapyramidal side effects it has demonstrated efficacy in treatment-resistant schizophrenic patients according to a number of psychiatrists with clinical experience with it, some weak clinical evidence supports this view too.

See also

• Quetiapine
• Zotepine

References

English Journal

• A Very Unusual Accidental Mechanical Asphyxia of Choking with a Whole Solea Solea.

• Busardò FP1, Mannocchi G1, Pugnetti P2, Santurro A1, Maggiordomo A2, Zaami S1.
• Journal of forensic sciences.J Forensic Sci.2017 Mar;62(2):511-514. doi: 10.1111/1556-4029.13261. Epub 2016 Dec 6.
• The case here reported involves a schizophrenic 19-year-old girl under treatment with clotiapine, which was well tolerated except for a moderate dry mouth. The woman ingested a whole sole (Solea solea), which caused a very rapid death by choking. A complete autopsy was performed 24 h later, as well
• PMID 27921301

• Pediatric clotiapine poisoning: clinical manifestations and toxicokinetics.

• Lurie Y1, Gopher A2, Hoffmann Y3, Bentur Y4.
• The American journal of emergency medicine.Am J Emerg Med.2016 Dec;34(12):2469.e1-2469.e2. doi: 10.1016/j.ajem.2016.06.059. Epub 2016 Jun 16.
• PMID 27567425

• Development of a Web-Based Clinical Decision Support System for Drug Prescription: Non-Interventional Naturalistic Description of the Antipsychotic Prescription Patterns in 4345 Outpatients and Future Applications.

• Berrouiguet S1,2, Barrigón ML3, Brandt SA4, Ovejero-García S3, Álvarez-García R5, Carballo JJ3, Lenca P2, Courtet P6; MEmind Study Group, Baca-García E7,8,9,10,11,12.
• PloS one.PLoS One.2016 Oct 20;11(10):e0163796. doi: 10.1371/journal.pone.0163796. eCollection 2016.
• PURPOSE: The emergence of electronic prescribing devices with clinical decision support systems (CDSS) is able to significantly improve management pharmacological treatments. We developed a web application available on smartphones in order to help clinicians monitor prescription and further propose
• PMID 27764107

Japanese Journal

• 10. 脳のグルタミン酸脱水素酵素に対する各種向精神薬の影響

• 川合 仁
• 医化学シンポジウム 10(0), 133-138, 1971
• … Oxypertine and clotiapine, which were fundamentally different in their chemical structures from the butyrophenone and phenothiazine derivatives, inhibited the reaction to a greater extent than chlorpromazine, perazine, fluphenazine and levomepromazine (phenothiazine derivatives). …
• NAID 130003358491

Related Links

• Clotiapine - RightDiagnosis.com - Right Diagnosis

Clotiapine information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Search Specialists by State and City

• Clotiapine for acute psychotic illnesses.

1. Cochrane Database Syst Rev. 2001;(1):CD002304. Clotiapine for acute psychotic illnesses. Carpenter S, Berk M. Update in Cochrane Database Syst Rev. 2004;(4):CD002304. BACKGROUND: Acute psychotic illness, especially ...