UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

Calcium mobilization is both required and sufficient for initiating chromatin decondensation during activation of peripheral T-cells.

Lee MD1, Bingham KN1, Mitchell TY1, Meredith JL1, Rawlings JS2.
Molecular immunology.Mol Immunol.2015 Feb;63(2):540-9. doi: 10.1016/j.molimm.2014.10.015. Epub 2014 Nov 8.
Antigen engagement of the T-cell receptor (TCR) induces a rapid and dramatic decondensation of chromatin that is necessary for T-cell activation. This decondensation makes T-cells competent to respond to interleukin-2 providing a mechanism to ensure clonotypic proliferation during an immune response
PMID 25453467

Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1.

Costa AI1, Koning D1, Ladell K2, McLaren JE2, Grady BP3, Schellens IM1, van Ham P4, Nijhuis M4, Borghans JA1, Keşmir C5, Price DA2, van Baarle D6.
Journal of virology.J Virol.2015 Jan 1;89(1):110-9. doi: 10.1128/JVI.01765-14. Epub 2014 Oct 15.
Although CD8(+) T cells are important for the control of HIV-1 in vivo, the precise correlates of immune efficacy remain unclear. In this study, we conducted a comprehensive analysis of viral sequence variation and T-cell receptor (TCR) repertoire composition across multiple epitope specificities in
PMID 25320304

AN ENTITY EVOLVING INTO A COMMUNITY: DEFINING THE COMMON ANCESTOR AND EVOLUTIONARY TRAJECTORY OF CHRONIC LYMPHOCYTIC LEUKEMIA STEREOTYPED SUBSET #4.

Sutton LA1, Papadopoulos G2, Hadzidimitriou A3, Papadopoulos S2, Kostareli E4, Rosenquist R1, Tzovaras D2, Stamatopoulos K5.
Molecular medicine (Cambridge, Mass.).Mol Med.2014 Dec 2. doi: 10.2119/molmed.2014.00140. [Epub ahead of print]
Patients with chronic lymphocytic leukemia (CLL) assigned to stereotyped subset #4 express highly homologous B-cell receptor immunoglobulin (BcR IG) sequences with intense intraclonal diversification (ID) in the context of ongoing somatic hypermutation (SHM). Their remarkable biological and clinical
PMID 25486132

Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death

Characterization of T Cell Receptor β Chains of Accumulating T Cells in Chronic Ongoing Myocarditis Demonstrated by Heterotopic Cardiac Transplantation in Mice

Nakamura Hiroshi,Kato Tomohiro,Yamamura Taisei,Yamamoto Takuo,Umemoto Seiji,Sekine Taichi,Nishioka Kusuki,Matsuzaki Masunori
Japanese circulation journal 65(2), 106-110, 2001-01-20
… Multiple clonotypic accumulations occurred in the donor heart after cardiac transplantation. …
NAID 110002567060

Combinatorial peptide libraries and biometric score matrices permit the quantitative analysis of specific and degenerate interactions between clonotypic TCR and MHC peptide ligands