3番染色体、第3染色体、第3番染色体

WordNet

a threadlike strand of DNA in the cell nucleus that carries the genes in a linear order; "humans have 22 chromosome pairs plus two sex chromosomes"

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染色体

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/01 23:40:50」(JST)

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Ideogram of human chromosome 3. Mbp means mega base pair. See locus for other notation.

Chromosome 3 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 3 spans almost 200 million base pairs (the building material of DNA) and represents about 6.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 3 likely contains between 1,100 and 1,500 genes.

Genes

The following are some of the genes located on chromosome 3:

AMOTL2: encoding protein]] Angiomotin-like protein 2
APEH: encoding enzyme Acylamino-acid-releasing enzyme
AZI2: encoding protein 5-azacytidine-induced protein 2
C3orf23: encoding protein Uncharacterized protein C3orf23
C3orf60/NDUFAF3: encoding enzyme NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
C3orf70: encoding protein C3orf70 (Chromosome 3 Open Reading Frame 70)

p-arm

ALAS1: aminolevulinate, delta-, synthase 1
BTD: biotinidase
CACNA2D3: calcium channel, voltage-dependent, alpha 2/delta subunit 3
CCR5: chemokine (C-C motif) receptor 5
CNTN4: Contactin 4
COL7A1: Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)
C3orf14-Chromosome 3 open reading frame 14: predicted DNA binding protein.
MITF: microphthalmia-associated transcription factor
MLH1: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
OXTR: oxytocin receptor
PTHR1: parathyroid hormone receptor 1
SCN5A: sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)
SLC25A20: solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
TMIE: transmembrane inner ear
VHL: von Hippel-Lindau tumor suppressor
FOXP1: Forkhead Box Protein P1
CRBN: Cereblon protein^[2]

q-arm

ADIPOQ: adiponectin
CAMPD1: Camptodactyly
CPOX: coproporphyrinogen oxidase (coproporphyria, harderoporphyria)
HGD: homogentisate 1,2-dioxygenase (homogentisate oxidase)
IFT122: intraflagellar transport gene 122
MCCC1: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
PCCB: propionyl Coenzyme A carboxylase, beta polypeptide
PDCD10: programmed cell death 10
PIK3CA: phosphoinositide-3-kinase, catalytic, alpha polypeptide
RAB7: RAB7, member RAS oncogene family
RHO: rhodopsin visual pigment
SOX2: transcription factor
USH3A: Usher syndrome 3A
ZNF9: zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)

Diseases and disorders

The following diseases and disorders are some of those related to genes on chromosome 3:

3-methylcrotonyl-CoA carboxylase deficiency
3q29 microdeletion syndrome
Alkaptonuria
Arrhythmogenic right ventricular dysplasia
Atransferrinemia
Autism
Autosomal Dominant Optic Atrophy
ADOA Plus Syndrome
Biotinidase deficiency
Blepharophimosis, epicanthus inversus and ptosis type 1
Breast/colon/lung/pancreatic cancer
Brugada syndrome
Castillo fever
Carnitine-acylcarnitine translocase deficiency
Cataracts
Cerebral cavernous malformation
Charcot-Marie-Tooth disease, type 2
Charcot-Marie-Tooth disease
Chromosome 3q duplication syndrome
Coproporphyria
Dandy-Walker syndrome
Deafness
Diabetes
Dopamine receptor
Dystrophic epidermolysis bullosa
Endplate acetylcholinesterase deficiency
Essential tremors
Ectrodactyly, Case 4
Glaucoma, primary open angle
Glycogen storage disease
Hailey-Hailey disease
Harderoporphyrinuria
Heart block, progressive/nonprogressive
Hereditary coproporphyria
Hereditary nonpolyposis colorectal cancer
HIV infection, susceptibility/resistance to
Hypobetalipoproteinemia, familial
Hypothermia
Leukoencephalopathy with vanishing white matter
Long QT syndrome
Lymphomas
Malignant hyperthermia susceptibility
Metaphyseal chondrodysplasia, Murk Jansen type
Microcoria
Moebius syndrome
Moyamoya disease
Mucopolysaccharidosis
Muir-Torre family cancer syndrome
Myotonic dystrophy, type 2
Myotonic dystrophy
Neuropathy, hereditary motor and sensory, Okinawa type
Night blindness
Nonsyndromic deafness, autosomal recessive
Nonsyndromic deafness
Ovarian cancer
Porphyria
Propionic acidemia
Protein S deficiency
Pseudo-Zellweger syndrome
Retinitis pigmentosa
Romano-Ward syndrome
Seckel Syndrome
Sensenbrenner syndrome
Septo-optic dysplasia
Short stature
Spinocerebellar ataxia
Sucrose intolerance
T-cell leukemia translocation altered gene
Usher syndrome type III
Usher syndrome (Finland)
Usher syndrome
von Hippel-Lindau syndrome
Waardenburg syndrome
Xeroderma pigmentosum, complementation group c

References

^ "Table 2.3: Human chromosome groups". Human Molecular Genetics (2nd ed.). Garland Science. 1999.
^ CRBN cereblon [Homo sapiens (human)] - Gene - NCBI

UpToDate Contents

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1. 染色体の転座、欠失、および逆位 chromosomal translocations deletions and inversions
2. 微細欠失症候群（1番～11番染色体） microdeletion syndromes chromosomes 1 to 11
3. 先天性の細胞遺伝学的異常 congenital cytogenetic abnormalities
4. 男性不妊症の原因 causes of male infertility
5. 性染色体異常 sex chromosome abnormalities

English Journal

Chromosome 3q29 deletion with gastrointestinal malformation: a case report.

Masarweh M.AbstractABSTRACT:
Journal of medical case reports.J Med Case Reports.2011 Jul 5;5(1):285. [Epub ahead of print]
ABSTRACT:INTRODUCTION: Most chromosome 3 deletions are associated with neuro-developmental and eye abnormalities. Here, we report a rare and unusual multiple congenital abnormality, including ano-rectal malformation, in conjunction with chromosome 3q29 segment deletion, which has not previously been
PMID 21729261

Identification of Cd101 as a Susceptibility Gene for Novosphingobium aromaticivorans-Induced Liver Autoimmunity.

Mohammed JP, Fusakio ME, Rainbow DB, Moule C, Fraser HI, Clark J, Todd JA, Peterson LB, Savage PB, Wills-Karp M, Ridgway WM, Wicker LS, Mattner J.SourceDivision of Immunobiology, Cincinnati Children's Hospital, Cincinnati, OH 45229;
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2011 Jul 1;187(1):337-49. Epub 2011 May 25.
Environmental and genetic factors define the susceptibility of an individual to autoimmune disease. Although common genetic pathways affect general immunological tolerance mechanisms in autoimmunity, the effects of such genes could vary under distinct immune challenges within different tissues. In t
PMID 21613619

Japanese Journal

Samia cynthia versus Bombyx mori : Comparative gene mapping between a species with a low-number karyotype and the model species of Lepidoptera

Yoshido Atsuo,Yasukochi Yuji,Sahara Ken
Insect Biochemistry and Molecular Biology 41(6), 370-377, 2011-06
We performed gene-based comparative FISH mapping between a wild silkmoth, Samia cynthia ssp. with a low number of chromosomes (2n = 25-28) and the model species, Bombyx mori (2n = 56), in order to ide …
NAID 120003043357

Xp11.2転座腎細胞癌の1例

堀江憲吾,菊地美奈,三輪好生,南舘謙,横井繁明,仲野正博,出口隆,江原英俊,浅野奈美,広瀬善信
泌尿器科紀要 57(3), 129-133, 2011-03-31
… The definitive diagnosis requires the evidence of several different reciprocal translocations involving the TFE3 gene located on chromosome Xp11.2. …
NAID 120003001366

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リンク元	「3番染色体」「第3染色体」「第3番染色体」

「3番染色体」

Chromosome 3 (human)
	Human chromosome 3 pair after G-banding. One is from mother, one is from father.
	Chromosome 3 pair in human male karyogram.
Features
Length (bp)	198,295,559 bp
Number of genes	2,203
Type	Autosome
Centromere position	Metacentric
Identifiers
RefSeq	NC_000003
GenBank	CM000665