クロラロース
- 関
- alpha-chloralose
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/03 10:23:15」(JST)
[Wiki en表示]
Chloralose
|
| Names |
| IUPAC name
(5ξ)-1,2-O-[2,2,2-Trichloroethylidene]-α-xylo-hexofuranose
|
| Identifiers |
|
CAS Number
|
15879-93-3 N |
|
Beilstein Reference
|
85418 |
| ChEMBL |
ChEMBL2104181 N |
| ChemSpider |
5414376 Y |
| EC Number |
240-016-7 |
| Jmol interactive 3D |
Image |
| KEGG |
C18707 N |
| MeSH |
Chloralose |
| PubChem |
7057995
40467114 (2R,3aR,5R,6R)-6-hydroxy-2-methyl-furo-5-yl
27525 (2R,5R,6S,6aR)-6-hydroxy-2-methyl-furo-5-yl
16211632 (1R)-dioxol, (2R,5R,6S,6aR)-6-hydroxy-2-methyl-furo-5-yl
186624 (1R)-dioxol, (3aR,5R,6S,6aR)-6-hydroxy-furo-5-yl
2723807 (2R,3aR,5R,6S,6aR)-6-hydroxy-2-methyl-furo-5-yl
85991 |
| RTECS number |
FM9450000 |
| UNII |
238BZ29MUE Y |
InChI
-
InChI=1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1 Y
Key: OJYGBLRPYBAHRT-IPQSZEQASA-N Y
-
InChI=1/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1
Key: OJYGBLRPYBAHRT-IPQSZEQABF
|
SMILES
-
C([C@H]([C@@H]1[C@@H]([C@@H]2[C@H](O1)O[C@@H](O2)C(Cl)(Cl)Cl)O)O)O
|
| Properties |
|
Chemical formula
|
C8H11Cl3O6 |
| Molar mass |
309.52 g·mol−1 |
| Melting point |
176 to 182 °C (349 to 360 °F; 449 to 455 K) |
| Hazards |
| Main hazards |
Harmful if swallowed
Harmful if inhaled
|
|
EU classification (DSD)
|
Xn |
| R-phrases |
R20/22 |
| S-phrases |
(S2) S16 S24/25 S28 |
| Related compounds |
|
Related compounds
|
Chloral hydrate |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
| N verify (what is YN ?) |
| Infobox references |
|
|
Chloralose is an avicide, and a rodenticide used to kill mice in temperatures below 15 °C. It is also widely used in neuroscience and veterinary medicine as an anesthetic and sedative.[1]
Chemically, it is a chlorinated acetal derivative of glucose.
It is listed in Annex I of Directive 67/548/EEC with the classification Harmful (Xn)
References
- ^ Silverman J, Muir WW (Jun 1993). "A review of laboratory animal anesthesia with chloral hydrate and chloralose". Lab Anim Sci. 43 (3): 210–6. PMID 8355479.
|
General anesthetics (N01A)
|
|
| Inhalational |
- Chloroethane (ethyl chloride)‡
- Chloroform‡
- Cyclopropane‡
- Desflurane
- Diethyl ether‡
- Enflurane
- Ethylene‡
- Fluroxene‡
- Halothane#
- Isoflurane
- Methoxyflurane
- Methoxypropane‡
- Nitrous oxide#
- Sevoflurane
- Trichloroethylene‡
- Vinyl ether‡
- Xenon
|
|
| Injection |
| Barbiturates |
- Hexobarbital
- Methohexital
- Narcobarbital
- Thiopental#
- Thiotetrabarbital
|
|
| Opioids |
- Alfentanil
- Anileridine‡
- Fentanyl
- Phenoperidine
- Remifentanil
- Sufentanil
|
|
| Arylcyclohexylamines |
- Esketamine
- Ketamine#
- Phencyclidine‡
- Tiletamine
|
|
| Others |
- Alfadolone
- Alfaxalone
- Etomidate
- Fospropofol
- Hydroxydione
- GHB
- Metomidate
- Midazolam
- Propanidid‡
- Propofol
|
|
|
-
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
|
Index of the central nervous system
|
|
| Description |
- Anatomy
- meninges
- cortex
- association fibers
- commissural fibers
- lateral ventricles
- basal ganglia
- diencephalon
- mesencephalon
- pons
- cerebellum
- medulla
- spinal cord
- Physiology
- Development
|
|
| Disease |
- Addiction
- Cerebral palsy
- Meningitis
- Demyelinating diseases
- Seizures and epilepsy
- Headache
- Stroke
- Sleep
- Congenital
- Injury
- Neoplasms and cancer
- Other
- Symptoms and signs
- head and neck
- eponymous
- lesions
- Tests
|
|
| Treatment |
- Procedures
- Drugs
- general anesthetics
- analgesics
- dependence
- epilepsy
- cholinergics
- migraine
- Parkinson's
- vertigo
- other
|
|
|
|
Pest control: Rodenticides
|
|
Anticoagulants /
Vitamin K antagonists |
|
Coumarins /
4-Hydroxycoumarins
|
|
1st generation
|
|
|
|
2nd generation
|
- Brodifacoum
- Bromadiolone
- Difenacoum
- Flocoumafen
|
|
|
|
1,3-Indandiones
|
- Chlorophacinone
- Pindone
- Diphacinone
|
|
|
Others
|
|
|
|
| Convulsants |
- Crimidine
- Phenylsilatrane
- Strychnine
- Tetramethylenedisulfotetramine
|
|
| Calciferols |
- Cholecalciferol
- Ergocalciferol
|
|
| Inorganic compounds |
- Aluminium phosphide
- Arsenic
- Barium carbonate
- Calcium phosphide
- Cyanide
- Thallium sulfate
- Zinc phosphide
|
|
| Organochlorine |
|
|
| Organophosphorus |
|
|
| Metabolic poisons |
- Bromethalin
- Fluoroacetamide
- 1,3-Difluoro-2-propanol (Gliftor)
- Sodium fluoroacetate
|
|
| Others |
- α-Naphthylthiourea
- Norbormide
- Pyrinuron
- Scilliroside
|
|
|
GABAA receptor positive allosteric modulators
|
|
| Alcohols |
- Brometone
- Butanol
- Chloralodol
- Chlorobutanol (cloretone)
- Ethanol (drinking alcohol)
- Ethchlorvynol
- Isobutanol
- Isopropanol
- Menthol
- Methanol
- Methylpentynol
- Pentanol
- Petrichloral
- Propanol
- tert-Butanol (2M2P)
- tert-Pentanol (2M2B)
- Tribromoethanol
- Trichloroethanol
- Triclofos
- Trifluoroethanol
|
|
| Barbiturates |
- (-)-DMBB
- Allobarbital
- Alphenal
- Amobarbital
- Aprobarbital
- Barbexaclone
- Barbital
- Benzobarbital
- Benzylbutylbarbiturate
- Brallobarbital
- Brophebarbital
- Butabarbital/Secbutabarbital
- Butalbital
- Buthalital
- Butobarbital
- Butallylonal
- Carbubarb
- CP-1414S
- Crotylbarbital
- Cyclobarbital
- Cyclopentobarbital
- Difebarbamate
- Enallylpropymal
- Ethallobarbital
- Eterobarb
- Febarbamate
- Heptabarb
- Heptobarbital
- Hexethal
- Hexobarbital
- Metharbital
- Methitural
- Methohexital
- Methylphenobarbital
- Narcobarbital
- Nealbarbital
- Pentobarbital
- Phenallymal
- Phenobarbital
- Phetharbital
- Primidone
- Probarbital
- Propallylonal
- Propylbarbital
- Proxibarbital
- Reposal
- Secobarbital
- Sigmodal
- Spirobarbital
- Talbutal
- Tetrabamate
- Tetrabarbital
- Thialbarbital
- Thiamylal
- Thiobarbital
- Thiobutabarbital
- Thiopental
- Thiotetrabarbital
- Valofane
- Vinbarbital
- Vinylbital
|
|
| Benzodiazepines |
|
|
| Carbamates |
- Carisbamate
- Carisoprodol
- Clocental
- Cyclarbamate
- Difebarbamate
- Emylcamate
- Ethinamate
- Febarbamate
- Felbamate
- Hexapropymate
- Lorbamate
- Mebutamate
- Meprobamate
- Nisobamate
- Pentabamate
- Phenprobamate
- Procymate
- Styramate
- Tetrabamate
- Tybamate
|
|
| Flavonoids |
- 6-Methylapigenin
- Ampelopsin (dihydromyricetin)
- Apigenin
- Baicalein
- Baicalin
- Catechin
- EGC
- EGCG
- Hispidulin
- Linarin
- Luteolin
- Rc-OMe
- Skullcap constituents (e.g., baicalin)
- Wogonin
|
|
| Imidazoles |
- Etomidate
- Metomidate
- Propoxate
|
|
| Kava constituents |
- 10-Methoxyyangonin
- 11-Methoxyyangonin
- 11-Hydroxyyangonin
- Desmethoxyyangonin
- 11-Methoxy-12-hydroxydehydrokavain
- 7,8-Dihydroyangonin
- Kavain
- 5-Hydroxykavain
- 5,6-Dihydroyangonin
- 7,8-Dihydrokavain
- 5,6,7,8-Tetrahydroyangonin
- 5,6-Dehydromethysticin
- Methysticin
- 7,8-Dihydromethysticin
- Yangonin
|
|
| Monoureides |
- Acecarbromal
- Apronal (apronalide)
- Bromisoval
- Carbromal
- Capuride
- Ectylurea
|
|
| Neuroactive steroids |
- Acebrochol
- Allopregnanolone
- Alfadolone
- Alfaxalone
- 3α-Androstanediol
- Androstenol
- Androsterone
- Cholesterol
- DHDOC
- 3α-DHP
- 5α-DHP
- 5β-DHP
- Etiocholanolone
- Ganaxolone
- Hydroxydione
- Minaxolone
- Org 20599
- Org 21465
- Pregnanolone (eltanolone)
- Progesterone
- Renanolone
- SAGE-217
- SAGE-689
- THDOC
|
|
| Nonbenzodiazepines |
- β-Carbolines: Abecarnil
- Gedocarnil
- Harmane
- SL-651,498
- ZK-93423; Cyclopyrrolones: Eszopiclone
- Pagoclone
- Pazinaclone
- Suproclone
- Suriclone
- Zopiclone; Imidazopyridines: Alpidem
- DS-1
- Necopidem
- Saripidem
- Zolpidem; Pyrazolopyrimidines: Divaplon
- Fasiplon
- Indiplon
- Lorediplon
- Ocinaplon
- Panadiplon
- Taniplon
- Zaleplon; Others: Adipiplon
- CGS-8216
- CGS-9896
- CGS-13767
- CGS-20625
- CL-218,872
- CP-615,003
- CTP-354
- ELB-139
- GBLD-345
- JM-1232
- L-838,417
- Lirequinil (Ro41-3696)
- NS-2664
- NS-2710
- NS-11394
- Pipequaline
- ROD-188
- RWJ-51204
- SB-205,384
- SX-3228
- TGSC01AA
- TP-003
- TPA-023
- TP-13
- U-89843A
- U-90042
- Viqualine
- Y-23684
|
|
| Phenols |
- Fospropofol
- Propofol
- Thymol
|
|
| Piperidinediones |
- Glutethimide
- Methyprylon
- Piperidione
- Pyrithyldione
|
|
| Pyrazolopyridines |
- Cartazolate
- Etazolate
- ICI-190,622
- Tracazolate
|
|
| Quinazolinones |
- Afloqualone
- Cloroqualone
- Diproqualone
- Etaqualone
- Mebroqualone
- Mecloqualone
- Methaqualone
- Methylmethaqualone
- Nitromethaqualone
- SL-164
|
|
| Volatiles/gases |
- Acetone
- Acetophenone
- Acetylglycinamide chloral hydrate
- Aliflurane
- Benzene
- Butane
- Butylene
- Centalun
- Chloral
- Chloral betaine
- Chloral hydrate
- Chloroform
- Cryofluorane
- Desflurane
- Dichloralphenazone
- Dichloromethane
- Diethyl ether
- Enflurane
- Ethyl chloride
- Ethylene
- Fluroxene
- Gasoline
- Halopropane
- Halothane
- Isoflurane
- Kerosine
- Methoxyflurane
- Methoxypropane
- Nitric oxide
- Nitrogen
- Nitrous oxide
- Norflurane
- Paraldehyde
- Propane
- Propylene
- Roflurane
- Sevoflurane
- Synthane
- Teflurane
- Toluene
- Trichloroethane (methyl chloroform)
- Trichloroethylene
- Vinyl ether
|
|
| Others/unsorted |
- 3-Hydroxybutanal
- α-EMTBL
- AA-29504
- Avermectins (e.g., ivermectin)
- Bromide compounds (e.g., lithium bromide, potassium bromide, sodium bromide)
- Carbamazepine
- Chloralose
- Chlormezanone
- Clomethiazole
- DEABL
- Dihydroergolines (e.g., dihydroergocryptine, dihydroergosine, dihydroergotamine, ergoloid (dihydroergotoxine))
- DS2
- Efavirenz
- Etazepine
- Etifoxine
- Fenamates (e.g., flufenamic acid, mefenamic acid, niflumic acid, tolfenamic acid)
- Fluoxetine
- Flupirtine
- Hopantenic acid
- Lanthanum
- Lavender oil
- Lignans (e.g., 4-O-methylhonokiol, honokiol, magnolol, obovatol)
- Loreclezole
- Menthyl isovalerate (validolum)
- Monastrol
- Niacin
- Nicotinamide (niacinamide)
- Org 25,435
- Phenytoin
- Propanidid
- Retigabine (ezogabine)
- Safranal
- SAGE-547
- Seproxetine
- Stiripentol
- Sulfonylalkanes (e.g., sulfonmethane (sulfonal), tetronal, trional)
- Terpenoids (e.g., borneol)
- Topiramate
- Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol)
- Unsorted benzodiazepine site PAMs: MRK-409 (MK-0343)
- TCS-1105
- TCS-1205
|
|
|
See also: GABAergics
|
|
English Journal
- Pudendal but not tibial nerve stimulation inhibits bladder contractions induced by stimulation of pontine micturition center in cats.
- Lyon TD1, Ferroni MC1, Kadow BT1, Slater RC1, Zhang Z2, Chang V1, Lamm V1, Shen B1, Wang J1, Roppolo JR3, de Groat WC3, Tai C4.
- American journal of physiology. Regulatory, integrative and comparative physiology.Am J Physiol Regul Integr Comp Physiol.2016 Feb 15;310(4):R366-74. doi: 10.1152/ajpregu.00490.2015. Epub 2015 Dec 16.
- This study examined the possibility that pudendal nerve stimulation (PNS) or tibial nerve stimulation (TNS) inhibits the excitatory pathway from the pontine micturition center (PMC) to the urinary bladder. In decerebrate cats under α-chloralose anesthesia, electrical stimulation of the PMC (40 Hz f
- PMID 26676253
- Mechanisms of Airway Responses to Esophageal Acidification in Cats.
- Lang IM1, Haworth ST2, Medda BK2, Forster HV2, Shaker R2.
- Journal of applied physiology (Bethesda, Md. : 1985).J Appl Physiol (1985).2016 Feb 4:jap.00758.2015. doi: 10.1152/japplphysiol.00758.2015. [Epub ahead of print]
- Acid in the esophagus causes airway constriction, tracheobronchial mucous secretion, and a decrease in tracheal mucociliary transport rate. This study was designed to investigate the neuropharmacological mechanisms controlling these responses. In chloralose anesthetized cats (N=72), we investigated
- PMID 26846551
- Manganese-enhanced MR imaging of brain activation evoked by noxious peripheral electrical stimulation.
- Cha M1, Lee K2, Lee C2, Cho JH2, Cheong C2, Sohn JH3, Lee BH4.
- Neuroscience letters.Neurosci Lett.2016 Feb 2;613:13-8. doi: 10.1016/j.neulet.2015.11.027. Epub 2015 Dec 28.
- As imaging technology develops, magnetic resonance imaging (MRI) has furthered our understanding of brain function by clarifying the anatomical structure and generating functional imaging data related to information processing in pain conditions. Recent studies have reported that manganese (Mn(2+))-
- PMID 26733299
Japanese Journal
- Transient neural energetics by FMRI for brief and long stimuli. [Emerging Frontiers in Brain Research: Crossroads of metabolic regulaltion, stress response and disease. The 11th Meeting of Hirosaki International Forum of Medical Science. Communication Center of Hirosaki University School of Medicine. March 27-28,2009. Hirosaki, Japan.]
- Herman Peter,Sanganahalli Basavaraju G.,Coman Daniel [他],Blumenfeld Hal,Hyder Fahmeed
- 弘前醫學 61(Supplement), S11-S22, 2010
- … We used multi-modal fMRI （at 11.7T） and neuronal signalmeasurements of local fi eld potential （LFP） and multi-unit activity （MUA） in α-chloralose anesthetized rats duringforepaw stimulation to show that respective transfer functions （of BOLD, CBV, CBF） generated by deconvolutionwith LFP（ or MUA） are time invariant, for events in the millisecond to minute range. …
- NAID 110007616936
- ラット大腸運動に対するモルヒネの影響:<I>in vivo</I> と <I>in vitro</I>での比較
- 樫尾 明彦,郭 試瑜,浅田 初枝 [他],久光 正
- 昭和医学会雑誌 68(4), 225-231, 2008
- モルヒネなどオピオイドの作用として, 消化管運動を低下させることが知られている.本研究では, その機序を探るため, モルヒネを麻酔下ラットに経静脈的に投与し, 自発的な大腸運動への影響を<I>in vivo</I>と摘出腸管 (<I>in vitro</I>) について検討した.ラットの大腸に自己製作した内圧測定用バルーン付きカテーテルを挿入し, 腸 …
- NAID 130001820522
- Morphineによる大腸運動抑制に対するβアドレナリン受容体の役割について
- 内藤 美智子,久光 正,梅澤 輝泰 [他],土岐 彰,八塚 正四,鈴木 淳一,鈴木 孝明,渡邉 理江
- 日本小児外科学会雑誌 42(2), 193-198, 2006-04-20
- … 動が抑制されることによることが示唆されている.本研究はmorphineによる大腸運動抑制において交感神経系,特にβアドレナリン受容体活性化が果たす役割について検討することを目的とした.【方法】Urethane+α-chloralose (ip)麻酔下でWistar系雄性ラット(体重250〜350g)の肛門から約4cmバルーン付きカテーテルを挿入し,圧トランスデューサーを介して腸管運動を記録した.薬剤は大腿静脈に留置したカテーテルを介して投与した.投 …
- NAID 110004734742
Related Pictures
★リンクテーブル★
[★]
- 英
- chloralose
- 関
- αクロラロース
[★]
αクロラロース、α-クロラロース
- 関
- chloralose