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1. 原発不明癌の分類およびマネージメントの概要overview of the classification and management of cancers of unknown primary site [show details]
…Squamous cell carcinoma (SCC) Neuroendocrine carcinoma, which may be either well differentiated or poorly differentiated; Poorly differentiated tumors, most of which are recognized as carcinomas by histologic …
2. 肺癌生存者へのアプローチの概要overview of approach to lung cancer survivors [show details]
… and 265,000 deaths due to lung cancer . Currently, there are an estimated 384,000 survivors of lung cancer in the United States, accounting for 4 percent of the adult cancer survivor population, and this …
3. 癌の治療中や治療後の小児に起きる睡眠障害sleep disorders during and after cancer in children [show details]
… increase over time and cause sleep disruption in cancer survivors. These include the anxiety and depression (any cancer); residual physical effects of the cancer, including chronic pain; and sometimes disruption …
4. 癌免疫療法の原則principles of cancer immunotherapy [show details]
…particularly in immunogenic tumors such as melanoma, non-small cell lung cancer, mismatch-repair deficient colorectal carcinoma, and bladder carcinoma . Evaluation of the effectiveness of immune checkpoint inhibitors …
5. 癌患者に生じる腎疾患の概要overview of kidney disease in the cancer patient [show details]
… increasing number of cancer survivors have or will develop kidney disease associated with malignancy or its treatment. A variety of renal complications can occur among cancer patients, including acute kidney …

English Journal

Pretumor microenvironment of hepatocellular carcinoma: Cancerization or anticancerization?

Li G, Ni A, Yu M.
Gene. 2019 Jun;701()46-54.
Tumor microenvironment (TM) has been deeply concerned. However, the pretumor microenvironment (PTM) was poorly understood. The purpose in this study was to explore the possible pathophysiological features of PTM before hepatocellular carcinoma (HCC) appearance. Mouse livers with no swelling but with
PMID 30902783

Review of Clinical Evidence over 10 Years on Prevention and Treatment of a Film-Forming Medical Device Containing Photolyase in the Management of Field Cancerization in Actinic Keratosis.

Puig S, Granger C, Garre A, Trullàs C, Sanmartin O, Argenziano G.
Dermatology and therapy. 2019 Jun;9(2)259-270.
Actinic keratosis (AK) is a common pathology that afflicts sun-exposed areas of the skin. It predominantly affects older and fair-skinned individuals suggesting an accumulative damage attributable to chronic sun exposure. The prevalence of AK has risen in the past decades and is expected to continue
PMID 30968311

Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations.

Ambele MA, Pepper MS, van Heerden MB, van Heerden WFP.
Head & neck. 2019 May;41(5)E62-E65.
Oral field cancerization describes a multifocal development process involving many cells at once in response to prolong exposure to carcinogens. This case demonstrated differential p16 expression in different sections of the same HPV negative tumor on the floor of mouth in a patient with history of
PMID 30552721

Japanese Journal

気管食道科領域におけるアルコール発がん : 広域発がん現象 (特集アルコールと気管食道科)

玉置将司,大橋真也,武藤学
日本気管食道科学会会報 = The journal of the Japan Broncho-Esophagological Society 69(5), 275-281, 2018
NAID 40021705629

食道扁平上皮癌の危険因子と頭頸部・胃を含むfield cancerization

横山顕
日本消化器病学会雑誌 115(10), 868-880, 2018
… 本邦の食道扁平上皮癌では食道・頭頸部・胃に多発重複発癌するfield cancerizationが特徴的である．飲酒・喫煙・野菜果物不足に加え，エタノールとアセトアルデヒドへの曝露が増えるADH1B低活性型とALDH2欠損型の組合せでリスクが増加する．ALDH2欠損を判別する簡易フラッシング質問紙法によるフラッシャーやその関連所見のMCV増大，メラノーシスは高危険群の特定に役立 …
NAID 130007496653

Epigenetic inactivation of FAT4 contributes to gastric field cancerization

Yoshida Satoshi,Yamashita Satoshi,Niwa Tohru,Mori Akiko,Ito Seiji,Ichinose Masao,Ushijima Toshikazu
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20(1), 136-145, 2017
NAID 40021062608

「癌化」

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英: malignant transformation、oncogenic transformation、transform、oncogenic、canceration、cancerization
同: 癌発生
関: 悪性転換、がん化、形質転換、トランスフォーム、発癌、発癌性、変換、悪性化、悪性形質転換、悪性形質発現、腫瘍プログレッション

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