UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 安定した慢性閉塞性肺疾患（COPD）のマネージメント management of stable chronic obstructive pulmonary disease
2. 乳幼児や小児の細気管支炎：治療、転帰、予防 bronchiolitis in infants and children treatment outcome and prevention
3. 難治性慢性閉塞性肺疾患（COPD）のマネージメント management of refractory chronic obstructive pulmonary disease
4. 成人における肺機能検査の概要 overview of pulmonary function testing in adults
5. 喘息におけるβ刺激剤：急性期投与および予防的使用 beta agonists in asthma acute administration and prophylactic use

English Journal

Bronchodilator and Anti-Inflammatory Action of Theophylline in a Model of Ovalbumin-Induced Allergic Inflammation.

Urbanova A1, Kertys M2, Simekova M3,4, Mikolka P5, Kosutova P5, Mokra D5, Mokry J2.
Advances in experimental medicine and biology.Adv Exp Med Biol.2016 Jun 23. [Epub ahead of print]
Phosphodiesterases (PDEs) represent a super-family of 11 enzymes hydrolyzing cyclic nucleotides into inactive 5' monophosphates. Inhibition of PDEs leads to a variety of cellular effects, including airway smooth muscle relaxation, inhibition of cellular inflammation, and immune responses. In this st
PMID 27334733

V Wasilewski N1, Fisher T2, Turcotte SE1, Fisher JT1, Lougheed MD3.
Journal of applied physiology (Bethesda, Md. : 1985).J Appl Physiol (1985).2016 May 1;120(9):1018-28. doi: 10.1152/japplphysiol.00737.2015. Epub 2016 Mar 3.
The pathophysiologic processes distinguishing classic asthma (CA), cough-variant asthma (CVA), and methacholine (MCh)-induced cough but normal airway sensitivity (COUGH) are inadequately understood and may be a result of differences in the ability to bronchodilate following a deep inspiration (DI).
PMID 26940655

Assessment of Parasympathetic Activity in Athletes: Comparing Two Different Methods.

Stang J1, Couto M, Stensrud T, Mowinckel P, Moreira A, Carlsen KH.
Medicine and science in sports and exercise.Med Sci Sports Exerc.2016 Feb;48(2):316-22. doi: 10.1249/MSS.0000000000000769.
INTRODUCTION: A variety of methods are used to assess parasympathetic activity in athletes targeting different organs; however, the reliability of or interchangeability between measurement procedures is not clear.OBJECTIVE: The purpose of this study is to identify the repeatability of two parasympat
PMID 26355246

Collagen Gel Contraction Assay Using Human Bronchial Smooth Muscle Cells and Its Application for Evaluation of Inhibitory Effect of Formoterol

Sakota Yusuke,Ozawa Yuji,Yamashita Hirotaka,Tanaka Hiroyuki,Inagaki Naoki
Biological and Pharmaceutical Bulletin 37(6), 1014-1020, 2014
… Present results indicate that the collagen gel contraction assay using human bronchial smooth muscle cells is useful for evaluating the effects of bronchodilating drugs, and that fluticasone potentiates the inhibitory effect of formoterol on histamine-induced collagen gel contraction. …
NAID 130004147344

Gandia Fedoua,Rouatbi Sonia,Latiri Imed,Guénard Hervé,Tabka Zouhair
Journal of Smooth Muscle Research 46(3), 157-164, 2010
… Results indicated that (1) MgF2 + NaCl 0.9%, MgF2 + acetic acid and MgSO4 reversed significantly the methacholine-induced bronchial constriction in rats and had a bronchodilating effect at the moment of its administration (2) MgF2 + acetic acid led to a greater decrease (P<0.05) of bronchial resistances when compared to that obtained from MgF2 + NaCl 0.9%, NaF exclusively and MgSO4 alone (3) inhaled NaF alone led to a significant bronchorelaxing effect (P<0.05) that starts at the sixth dose of MeCh (17 mg/L). …
NAID 130000860970

Comparison of Enantiomers of SPFF, a Novel β_2-Adrenoceptor Agonist, in Bronchodilating Effect in Guinea Pigs(Pharmacology)

Hao Zhihui,Zhang Yuyang,Pan Li [他],SU Xing,CHENG Maosheng,WANG Minwei,ZHAO Houde,WU Yingliang
Biological & pharmaceutical bulletin 31(5), 866-872, 2008-05-01
Previous study on racemic SPFF [2-(4-amino-3-chloro-5-trifluomethyl-phenyl)-2-tert-butylamino-ethanol hydrochloride], a novel β_2-adrenoceptor agonist, has validated that it is a potent, long-acting b …
NAID 110006663943