WordNet

of or belonging to neither the right nor the left politically or intellectually
a building dedicated to a particular activity; "they were raising money to build a new center for research" (同)centre
(American football) the position of the player on the line of scrimmage who puts the ball in play; "it is a centers responsibility to get the football to the quarterback"
a position on a basketball team of the player who participates in the jump that starts the game
the position on a hockey team of the player who participates in the face off at the beginning of the game
a place where some particular activity is concentrated; "they received messages from several centers" (同)centre
the sweet central portion of a piece of candy that is enclosed in chocolate or some other covering (同)centre
the object upon which interest and attention focuses; "his stories made him the center of the party" (同)centre, center of attention, centre of attention
an area that is approximately central within some larger region; "it is in the center of town"; "they ran forward into the heart of the struggle"; "they were in the eye of the storm" (同)centre, middle, heart, eye
a point equidistant from the ends of a line or the extremities of a figure (同)centre, midpoint
a cluster of nerve cells governing a specific bodily process; "in most people the speech center is in the left hemisphere" (同)centre, nerve_center, nerve centre
(football) the person who plays center on the line of scrimmage and snaps the ball to the quarterback; "the center fumbled the handoff" (同)snapper
(basketball) the person who plays center on a basketball team
(ice hockey) the person who plays center on a hockey team
politically moderate persons; centrists
the middle of a military or naval formation; "they had to reinforce the center"
move into the center; "That vase in the picture is not centered" (同)centre
equally distant from the extremes (同)halfway, middle, midway
kill by smashing someones skull
mental ability; "hes got plenty of brains but no common sense" (同)brainpower, learning_ability, mental capacity, mentality, wit
that part of the central nervous system that includes all the higher nervous centers; enclosed within the skull; continuous with the spinal cord (同)encephalon
the brain of certain animals used as meat
hit on the head
cross a river where its shallow
the act of crossing a stream or river by wading or in a car or on a horse (同)fording
a shallow area in a stream that can be forded (同)crossing
a fractional monetary unit of several countries

PrepTutorEJDIC

《時間・距離》『…の間』 / 《利益・貢献》『…のために』 / 《適応・用途》『…向きの(に);』…用の(に);…のための(に) / 《目的・意向》『…のために,』に / 《敬意・記念》『…のために;』…を記念して / 《獲得・追求》『…を得るために』,を求めて / 《行く先・方向》『…あてに;』…[方面]行きの,に向けて / 《交換・報償など》『…に対して』;…と引き換えに;…のお返しに / 《原因・理由》『…のために』,なので / 《代理・代表》『…の代わりに;』…を代表して / 《形容詞の後に用いて》『…にとって,』には / 《比較級の後に用いて》『…の結果として,』…のために / 《対比》『…としては,』のわりには / 《関連》『…について,』の点では / 《資格・属性》『…として』 / 《賛成・支持》…『に賛成して』,を支持して / 《傾向・好み》…『に対する』,には / 《模倣》《おもに米》《英文》…の名を取って(after) / 《割合》…に対して / 《『for』+『名』〈人〉+『to』 doの形で,〈人〉が不定詞to doの意味上の主語を表して》…が(…することは,…するために) / […というのは]…だから
『脳』,脳髄 / 《しばしば複数形で》『頭脳』,『知力』 / 《話》秀才,知的指導者 / …‘の'頭を打ち砕く
(川などの)浅瀬 / 〈川〉‘の'浅瀬を渡る
〈C〉『セント』(1ドルの1/100;米国・カナダの貨幣単位;《略》￠) / 〈C〉1セント銅貨 / 〈U〉(単位としての)100

UpToDate Contents

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1. 成人における頭蓋骨骨折 skull fractures in adults
2. 統合失調症に対するクロザピン投与のガイドライン guidelines for prescribing clozapine in schizophrenia
3. シェーグレン症候群における口内乾燥およびその他の非眼結膜炎症状の治療 treatment of dry mouth and other non ocular sicca symptoms in sjogrens syndrome
4. 頭頚部癌の後期合併症のマネージメントおよびその治療 management of late complications of head and neck cancer and its treatment
5. 成人における放射線障害の生物学および臨床的特徴 biology and clinical features of radiation injury in adults

English Journal

Methamphetamine-withdrawal stress activates PACAP-DBI pathway in rat salivary gland, resulting in inhibition of salivary secretion.

Okubo M1, Yoshikawa M, Shinomiya T, Kawaguchi M.
The Tokai journal of experimental and clinical medicine.Tokai J Exp Clin Med.2013 Jul 20;38(2):55-61.
The purpose of this study was to investigate activation of inhibitory regulation pathways by methamphetamine (METH)-withdrawal stress in rat salivary gland. Our previous study showed that METH-withdrawal stress activated steroid biosynthesis and that pregnenolone produced during the early stage of t
PMID 23868736

Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation.

Daigle TL1, Caron MG.
The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2012 Aug 15;32(33):11461-6. doi: 10.1523/JNEUROSCI.2234-12.2012.
Although G-protein-coupled receptor kinase 2 (GRK2) is the most widely studied member of a family of kinases that has been shown to exert powerful influences on a variety of G-protein-coupled receptors, its role in the brain remains largely unknown. Here we report the localization of GRK2 in the mou
PMID 22895728

The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: bladder selectivity based on in vivo drug-receptor binding characteristics of antimuscarinic agents for treatment of overactive bladder.

Yoshida A1, Fujino T, Maruyama S, Ito Y, Taki Y, Yamada S.
Journal of pharmacological sciences.J Pharmacol Sci.2010;112(2):142-50. Epub 2010 Feb 4.
We have reviewed the binding of antimuscarinic agents, used to treat urinary dysfunction in patients with overactive bladder, to muscarinic receptors in target and non-target tissues in vivo. Transdermal administration of oxybutynin in rats led to significant binding in the bladder without long-term
PMID 20134113

Japanese Journal

The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Bladder Selectivity Based on In Vivo Drug-Receptor Binding Characteristics of Antimuscarinic Agents for Treatment of Overactive Bladder

Yoshida Akira,Fujino Tomomi,Maruyama Shuji,Ito Yoshihiko,Taki Yuko,Yamada Shizuo
Journal of Pharmacological Sciences 112(2), 142-150, 2010
… Transdermal administration of oxybutynin in rats led to significant binding in the bladder without long-term binding in the submaxillary gland and the abolishment of salivation evoked by oral oxybutynin. … In vivo quantitative autoradiography using (+)N-[11C]methyl-3-piperidyl benzilate in rats showed significant occupancy of brain muscarinic receptors on intravenous injection of oxybutynin, propiverine, solifenacin, and tolterodine. …
NAID 130000160421

咀嚼運動と唾液分泌との関連性について

西川泰央,吉田洋
歯科医学 58(2), 123-132, 1995-04-25
ウレタン・クロラローズで麻酔したネコを用いて, 末梢入力に対する反射性の唾液(顎下腺唾液)分泌を調べるとともに, 咀嚼運動関連中枢である視床下部外側野, 扁桃体, 大脳皮質顔面野および大脳皮質咀嚼野への電気刺激による唾液分泌を調べて, 唾液分泌を含めた咀嚼運動への上位中枢の役割を検討した. 除脳動物を用いて口腔感覚による反射性の唾液分泌を調べたところ, 通常の咀嚼時に生ずるような非侵害刺激(触刺激 …
NAID 110001724617

2-(4-Benzyl-piperidino)-1-(4-hydroxyphenyl)-1-propanol(Ifenprodil)の連続投与によるその薬理作用におよぼす影響

水沢英甫,永瀬毅,藤原寛,酒井賢,榊原栄一
日本薬理学雑誌 73(5), 517-526, 1977
… for 5 to 30 days. … Dose of 200 mg/kg/day slightly inhibited body weight gain for 30 days. … Both doses of the drug decreased motor activity and produced a myorelaxation of extremities, ptosis and salivation in a dose-dependent manner; … In the aorta isolated from rats treated for 30 days with ifenprodil, the contractile response to noradrenaline was approximately the same as seen with controls, and pA2 …
NAID 130000758787